Metabolomics and Data-Driven Bioinformatics Revealed Key Maternal Metabolites Related to Fetal Lethality via Di(2-ethylhexyl)phthalate Exposure in Pregnant Mice
Abstract:We performed serum
metabolome analysis of di(2-ethylhexyl)phthalate
(DEHP)-exposed and control pregnant mice. Pregnant mice (
n
= 5) were fed a DEHP-containing diet (0.1% or 0.2% DEHP) or a normal
diet (control) from gestational days 0–18. After maternal exposure
to 0.2% DEHP there were no surviving fetuses, indicating its strong
fetal lethality. There were no significant differences in the numbers
of fetuses and placentas between the 0.1% DEHP and control groups,
although fetal viabilit… Show more
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