Metabolomics: An Emerging “Omics” Platform for Systems Biology and Its Implications for Huntington Disease Research
Sumeyya Akyol,
Nadia Ashrafi,
Ali Yilmaz
et al.
Abstract:Huntington’s disease (HD) is a progressive, fatal neurodegenerative disease characterized by motor, cognitive, and psychiatric symptoms. The precise mechanisms of HD progression are poorly understood; however, it is known that there is an expansion of the trinucleotide cytosine-adenine-guanine (CAG) repeat in the Huntingtin gene. Important new strategies are of paramount importance to identify early biomarkers with predictive value for intervening in disease progression at a stage when cellular dysfunction has… Show more
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