2008
DOI: 10.1093/brain/awm304
|View full text |Cite
|
Sign up to set email alerts
|

Metabolomic profiling to develop blood biomarkers for Parkinson's disease

Abstract: The development of biomarkers for the diagnosis and monitoring disease progression in Parkinson's disease (PD) is of great importance since diagnosis based on clinical parameters has a considerable error rate. In this study, we utilized metabolomic profiling using high performance liquid chromatography coupled with electrochemical coulometric array detection (LCECA) to look for biomarkers in plasma useful for the diagnosis of PD. We examined 25 controls and 66 PD patients. We also measured 8-hydroxy-2-deoxygua… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

15
285
1
7

Year Published

2009
2009
2019
2019

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 368 publications
(308 citation statements)
references
References 41 publications
15
285
1
7
Order By: Relevance
“…Lower urate levels have been associated with higher risk of PD, as well as more rapid clinical progression of PD (5,6) and possibly other neurodegenerative diseases (22,23). Similarly, lower urate levels have been consistently reported in PD patients compared with control subjects (24,25). However, no experimental evidence has directly linked hypouricemia to neurodegeneration in vivo.…”
Section: Discussionmentioning
confidence: 99%
“…Lower urate levels have been associated with higher risk of PD, as well as more rapid clinical progression of PD (5,6) and possibly other neurodegenerative diseases (22,23). Similarly, lower urate levels have been consistently reported in PD patients compared with control subjects (24,25). However, no experimental evidence has directly linked hypouricemia to neurodegeneration in vivo.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, plasma or serum urate levels are lower in people with PD [44,45] and ALS [46,47] than healthy controls. Further, in postmortem substantia nigra tissue, urate levels are lower in patients with PD than in age-matched controls [12].…”
Section: Urate and Its Determinants Are A Risk Factor For Neurodegenementioning
confidence: 99%
“…this technique is an effective tool for Tissue metabolomic fingerprinting reveals metabolic disorders associated with human gastric cancer morbidity disease diagnosis (13)(14)(15), biomarker screening (16)(17)(18)(19)(20) and characterization of biological pathways (11). recent technological advances in NMr spectroscopy and mass spectrometry have further improved the sensitivity and spectral resolution of cancer metabolomic study (21).…”
Section: Introductionmentioning
confidence: 99%