Metabolomic Profiling of Serum from Myeloma and MGUS Patients - a Novel Strategy to Identify Potential Biomarkers of Myeloma Development and Progression
Abstract:Introduction: Drivers that underlie the progression of MGUS (Monoclonal gammopathy of undetermined significance) to multiple myeloma are yet largely unknown. Because of the vast number of potential players, these drivers may not necessarily aimed to transform plasma cell or the bone marrow niche, but rather remodel a supporting microenvironment. Metabolic alterations have been linked to cancer development and resistance to chemotherapy. It has been suggested that high rates of glycolysis and glutaminolysis are… Show more
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