Metabolomic profiling of asthma: Diagnostic utility of urine nuclear magnetic resonance spectroscopy

Saude, Erik J.; Skappak, Christopher; Regush, Shana; Cook, Kim K.; Ben-Zvi, Amos; Becker, Allan B.; Moqbel, Redwan; Sykes, Brian D.; Rowe, Brian H.; Adamko, Darryl J.

doi:10.1016/j.jaci.2010.12.1077

Cited by 150 publications

(171 citation statements)

References 40 publications

(33 reference statements)

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“…atopic and eosinophilic phenotypes) [163,164], whereas both predictive biomarkers and treatments for asthmatics, whose disease does not show presence of the type 2 inflammation are very limited. Furthermore, it is important to mention that the phenotyping, endotyping, and selecting biomarkers for the personalized approach do not necessarily include single biomolecules, but rather be composed of properly selected constellations or signatures of proteins and other peptides, transcriptomes, genes, microRNAs [164] and metabolites [165,166]. Finally, there is a need for more evidence on the consistency of severe asthma phenotypes, throughout the clinical course of severe asthma [23,159,163,167–169].…”

Section: Management Of Severe Asthmamentioning

confidence: 99%

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Porsbjerg

Ulrik

Skjold

et al. 2018

European Clinical Respiratory Journal

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Although a minority of asthma patients suffer from severe asthma, they represent a major clinical challenge in terms of poor symptom control despite high-dose treatment, risk of exacerbations, and side effects. Novel biological treatments may benefit patients with severe asthma, but are expensive, and are only effective in appropriately targeted patients. In some patients, symptoms are driven by other factors than asthma, and all patients with suspected severe asthma (‘difficult asthma’) should undergo systematic assessment, in order to differentiate between true severe asthma, and ‘difficult-to-treat’ patients, in whom poor control is related to factors such as poor adherence or co-morbidities. The Nordic Consensus Statement on severe asthma was developed by the Nordic Severe Asthma Network, consisting of members from Norway, Sweden, Finland, Denmark, Iceland and Estonia, including representatives from the respective national respiratory scientific societies with the aim to provide an overview and recommendations regarding the diagnosis, systematic assessment and management of severe asthma. Furthermore, the Consensus Statement proposes recommendations for the organization of severe asthma management in primary, secondary, and tertiary care.

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Section: Management Of Severe Asthmamentioning

confidence: 99%

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Porsbjerg

Ulrik

Skjold

et al. 2018

European Clinical Respiratory Journal

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“…Oxidative stress resulting from pulmonary reactive oxygen species formation is involved in asthma, leading to physiologic damage. 1 Asthma exacerbation is associated with increased oxidative stress, 2 with increased levels of carbon monoxide, nitric oxide, nitrotyrosine, and H 2 O 2 found in breath condensate. Aldehydes and alkanes, the end products of lipid peroxidation, are also known to be involved in asthma-related oxidative stress.…”

Section: To the Editormentioning

confidence: 99%

“…These metabolites are critically altered in asthmatic patients. 2 Moreover, changes in metabolites, such as citrate and alanine, suggest a disturbance of the tricarboxylic acid cycle, whereas altered levels of trimethylamine-N-oxide, hippurate, and phenylacetylglutamine might be related to diet.…”

Section: To the Editormentioning

confidence: 99%

“…The mechanism(s) responsible for the loss of lung elastic recoil in acute 1 and chronic asthma 2-7 remains unknown, especially with normal diffusing capacity and normal or only mild parenchymal attenuation of lung density on highresolution thin-section lung computed tomography (CT) at full inspiration. 2 Here, in a prospective study, we investigated the potential pathophysiologic mechanism(s) limiting maximal expiratory airflow (Vmax E ) after optimal clinical improvement. Our hypothesis is that undiagnosed diffuse breakdown of lung tissue leading to mild, diffuse emphysema may be responsible for both the loss of lung elastic recoil and persistent expiratory airflow limitation.…”

Section: To the Editormentioning

confidence: 99%

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Urinary metabolomic changes as a predictive biomarker of asthma exacerbation

Loureiro

Duarte

Gomes

et al. 2014

Journal of Allergy and Clinical Immunology

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“…NMR spectroscopy has advantages over MS in that it requires minimal sample preparation, is nondestructive to the sample, and produces data with a greater reproducibility. NMR-based metabolomics has been used for biomarker identification in a wide range of fields; recent examples include diagnosis of earlystage epithelial ovarian cancer [25], diagnosis of cerebral infarction [26], identifying severity of chronic liver failure [27], and diagnosis of children with asthma [28]. Of particular significance to the current study is the recent investigation of metabolic changes in traumatic critically ill patients [29].…”

Section: Introductionmentioning

confidence: 99%

Metabolic Profiling of Patients Undergoing Elective Aortic Aneurysm Repair Surgery: Correlation with Anaerobic Threshold

McRae

Howard

Homer-Vanniasinkam

et al. 2012

ISRN Vascular Medicine

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The anaerobic threshold (AT) measured by the cardiopulmonary exercise (CPX) test is becoming an established means of identifying patients at high risk of developing cardiac complications perioperatively. The aim of the present study was to investigate the relationship between AT and the plasma metabolic profile of patients undergoing aortic aneurysm repair surgery to see if an alternative or adjunct to the CPX test could be devised. Plasma was obtained from 15 male patients classified (through preoperative CPX tests) as having high (≥11.0 mL kg −1 min −1 ) or low (<11.0 mL kg −1 min −1 ) AT before and 1, 2, 24, 48, and 72 hours after elective open aortic aneurysm surgery. Samples were analysed using 1 H-NMR spectroscopy coupled with multivariate statistical analysis. Principal components analysis (PCA) and partial least squares discriminant analysis (PLS-DA) distinguished between low-and high-AT patients postoperatively, with high AT patients being more tightly clustered. High AT patients had higher plasma lipid and lower 3-hydroxybutyrate and acetoacetate levels than low AT patients post-operatively. Similar differences were identified preoperatively. 1 H-NMR metabolic profiling of plasma has identified molecules whose concentration correlates with AT scores. These may prove a useful biomarker in conjunction with AT in predicting response to major surgical procedures.

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Metabolomic profiling of asthma: Diagnostic utility of urine nuclear magnetic resonance spectroscopy

Cited by 150 publications

References 40 publications

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Urinary metabolomic changes as a predictive biomarker of asthma exacerbation

Metabolic Profiling of Patients Undergoing Elective Aortic Aneurysm Repair Surgery: Correlation with Anaerobic Threshold

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