Metabolomic profiles of sleep-disordered breathing are associated with hypertension and diabetes mellitus development

Zhang, Ying; Yu, Bing; Qi, Qibin; Azarbarzin, Ali; Chen, Han; Shah, Neomi A.; Ramos, Alberto R.; Zee, Phyllis C.; Cai, Jianwen; Daviglus, Martha L.; Boerwinkle, Eric; Kaplan, Robert; Liu, Peter Y.; Redline, Susan; Sofer, Tamar

doi:10.1038/s41467-024-46019-y

Cited by 4 publications

(1 citation statement)

References 71 publications

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“…Patients with OSA present significant heterogeneity and diversity in clinical presentation and responses to treatment [4][5][6]. Moreover, OSA, in its heterogenous presentation, is related to comorbidities' occurrence, and co-evolution and aggregation can emerge over time [7][8][9]. The first-line treatment for OSA is continuous positive airway pressure (CPAP), which opens and stabilizes the upper airways during sleep.…”

Section: Introductionmentioning

confidence: 99%

The Future of Telemedicine for Obstructive Sleep Apnea Treatment: A Narrative Review

Bailly,

Mendelson,

Baillieul

et al. 2024

JCM

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Obstructive sleep apnea is a common type of sleep-disordered breathing associated with multiple comorbidities. Nearly a billion people are estimated to have obstructive sleep apnea, which carries a substantial economic burden, but under-diagnosis is still a problem. Continuous positive airway pressure (CPAP) is the first-line treatment for OSAS. Telemedicine-based interventions (TM) have been evaluated to improve access to diagnosis, increase CPAP adherence, and contribute to easing the follow-up process, allowing healthcare facilities to provide patient-centered care. This narrative review summarizes the evidence available regarding the potential future of telemedicine in the management pathway of OSA. The potential of home sleep studies to improve OSA diagnosis and the importance of remote monitoring for tracking treatment adherence and failure and to contribute to developing patient engagement tools will be presented. Further studies are needed to explore the impact of shifting from teleconsultations to collaborative care models where patients are placed at the center of their care.

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Section: Introductionmentioning

confidence: 99%

The Future of Telemedicine for Obstructive Sleep Apnea Treatment: A Narrative Review

Bailly,

Mendelson,

Baillieul

et al. 2024

JCM

View full text Add to dashboard Cite

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Predictors and markers of the cardiovascular impact of obstructive sleep apnoea

Dodani,

Pinilla,

Sánchez-de-la-Torre

2024

Current Opinion in Pulmonary Medicine

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Purpose of review Obstructive sleep apnoea (OSA) is the most common form of sleep-disordered breathing and has been linked to cardiovascular health. However, some of the findings supporting this are controversial. These discrepancies might be a result of heterogeneity among OSA patients, and thus, additional information would be required to better stratify OSA patients according to cardiovascular risk. In this review, we aim to discuss the potential of biomarkers to fulfil this role. Recent findings Randomized controlled trials have been unable to confirm whether OSA treatment with continuous positive airway pressure (CPAP) has a positive effect on cardiovascular outcomes. Emerging physiology-based metrics of OSA seem to be more suitable for identifying patients at higher risk of cardiovascular disease and predicting the effects of CPAP outcomes on cardiovascular health. Similarly, blood-based molecular markers have gained attention in this context over the last few years. Summary Accurate cardiovascular risk stratification and appropriate treatment allocation for OSA patients remain challenging. However, significant efforts are being made to develop novel tools to address these important issues.

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Untargeted Metabolome Atlas for Sleep Phenotypes in the Hispanic Community Health Study/Study of Latinos

Zhang,

Spitzer,

Zhang

et al. 2024

Preprint

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Sleep is essential to maintaining health and wellbeing of individuals, influencing a variety of outcomes from mental health to cardiometabolic disease. This study aims to assess the relationships between various sleep phenotypes and blood metabolites. Utilizing data from the Hispanic Community Health Study/Study of Latinos, we performed association analyses between 40 sleep phenotypes, grouped in several domains (i.e., sleep disordered breathing (SDB), sleep duration, timing, insomnia symptoms, and heart rate during sleep), and 768 metabolites measured via untargeted metabolomics profiling. Network analysis was employed to visualize and interpret the associations between sleep phenotypes and metabolites. The patterns of statistically significant associations between sleep phenotypes and metabolites differed by superpathways, and highlighted subpathways of interest for future studies. For example, some xenobiotic metabolites were associated with sleep duration and heart rate phenotypes (e.g. 1H-indole-7-acetic acid, 4-allylphenol sulfate), while ketone bodies and fatty acid metabolism metabolites were associated with sleep timing measures (e.g. 3-hydroxybutyrate (BHBA), 3-hydroxyhexanoylcarnitine (1)). Heart rate phenotypes had the overall largest number of detected metabolite associations. Many of these associations were shared with both SDB and with sleep timing phenotypes, while SDB phenotypes shared relatively few metabolite associations with sleep duration measures. A number of metabolites were associated with multiple sleep phenotypes, from a few domains. The amino acids vanillylmandelate (VMA) and 1-carboxyethylisoleucine were associated with the greatest number of sleep phenotypes, from all domains other than insomnia. This atlas of sleep-metabolite associations will facilitate hypothesis generation and further study of the metabolic underpinnings of sleep health.

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Metabolomic profiles of sleep-disordered breathing are associated with hypertension and diabetes mellitus development

Cited by 4 publications

References 71 publications

The Future of Telemedicine for Obstructive Sleep Apnea Treatment: A Narrative Review

The Future of Telemedicine for Obstructive Sleep Apnea Treatment: A Narrative Review

Predictors and markers of the cardiovascular impact of obstructive sleep apnoea

Untargeted Metabolome Atlas for Sleep Phenotypes in the Hispanic Community Health Study/Study of Latinos

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