Metabolomic Profile of Abdominal Aortic Aneurysm

Abstract

Abdominal aortic aneurysm (AAA) is characterized by structural deterioration of the aortic wall, leading to aortic dilation and rupture. The aim was to compare 183 low molecular weight metabolites in AAA patients and aorta-healthy controls and to explore if low molecular weight metabolites are linked to AAA growth. Blood samples were collected from male AAA patients with fast (mean 3.3 mm/year; range 1.3–9.4 mm/year; n = 39) and slow growth (0.2 mm/year; range −2.6–1.1 mm/year; n = 40), and from controls with non-aneurysmal aortas (n = 79). Targeted analysis of 183 metabolites in plasma was performed with AbsoluteIDQ p180 kit. The samples were measured on a QTRAP 4500 coupled to an Agilent 1260 series HPLC. The levels of only four amino acids (histidine, asparagine, leucine, isoleucine) and four phosphatidylcholines (PC.ae.C34.3, PC.aa.C34.2, PC.ae.C38.0, lysoPC.a.C18.2) were found to be significantly lower (p < 0.05) after adjustment for confounders among the AAA patients compared with the controls. There were no differences in the metabolites distinguishing the AAA patients with slow or fast growth from the controls, or distinguishing the patients with slow growth from those with fast growth. The current study describes novel significant alterations in amino acids and phosphatidylcholines metabolism associated with AAA occurrence, but no associations were found with AAA growth rate.

Targeting metabolism in aortic aneurysm and dissection: from basic research to clinical applications

“…Another study demonstrated a correlation between amino acid metabolites and AAA growth. Significant reductions in four amino acids, including histidine, aspartate, leucine, and isoleucine, were found in abdominal aortic aneurysms, but no abdominal aortic aneurysm growth rates were found 66 . Plasma amino acid profiles were markedly different in patients with AAD compared with patients with coronary artery disease.…”

“…Therefore, we summarized the metabolic profile of AAD patients to contribute to provide potential targets for AAD clinical treatment (Table 2 ). Overall, the main observations were that the AAs and phosphatidylcholine levels were decreased 165 , and the metabolism of sphingolipids, lysophospha-tidylcholine, cholesterol, and acylcarnitine was disturbed in AAA patients compared with healthy subjects 166 . A combination of salicylic acid, pregnenolone sulfate, 5-Lglutamyl-L-alanine, and 3-hexanone with mevalonic acid could serve as a biomarker to distinguish AAA and atherosclerosis 167 .…”

Integration of LC-MS-Based and GC-MS-Based Metabolic Profiling to Reveal the Effects of Domestication and Boiling on the Composition of Duck Egg Yolks

“…Metabolomics, which is the study of the small molecular metabolites of an organism or cell in a specific physiological state, is used to identify novel metabolites or changes in the ratio of metabolites [ 7 ]. Metabolomics can be applied in various fields such as health [ 8 , 9 , 10 ], plant [ 11 , 12 ], environmental [ 13 , 14 ], and food and nutrition sciences [ 15 , 16 , 17 ]. Depending on the research purpose, it can be divided into untargeted and targeted metabolomics.…”

Shared Genetic Susceptibility between Abdominal Aortic Aneurysm and Cardiometabolic Traits

“…Plaques consisting of lipids, blood cells and other plasma substances accumulate around the lesion sites, with abundant infiltration of innate and adaptive immune cells both in the thrombus and the arterial wall 2 . Meanwhile, metabolic homeostasis is perturbed, resulting in enhanced glycolysis in the aortic wall 5 and altered serum levels of amino acids and lipids 6, 7, 8 . For example, circulating total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides, and sulfur amino acids are elevated, whereas high-density lipoprotein cholesterol (HDL-C) and phosphatidylcholines are reduced.…”