Metabolomic fingerprinting of Brazilian marine sponges: a case study of Plakinidae species from Fernando de Noronha Archipelago

Fagundes, Thayssa da Silva Ferreira; Silva, Larissa Ramos G da; Brito, Mateus de Freitas; Schmitz, Letícia S.S.; Rigato, Dhiego B; Jimenez, Paula Christine; Soares, Angélica Ribeiro; Costa-Lotufo, Letı́cia V.; Muricy, Guilherme; Vasconcelos, Thatyana R. A.; Cass, Quézia B.; Valverde, Alessandra L.

doi:10.1007/s00216-021-03385-6

Cited by 4 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the availability of the spectral library of a compound is very important in accelerating such identification. Several studies on metabolomics in sponges and their associated microbes reported that the use of LC-MS and GC-MS resulted in complex chemical profiles, thus requiring a reliable spectral library to assist the identification process; several studies used molecular networking methods combined with a cluster analysis in the identification of compounds (Alkhalifah, 2021;Erngren et al, 2021;Fagundes et al, 2021;Ho et al, 2021;Yuliana et al, 2011). Therefore, it is highly recommended to apply metabolomics on sponges and their associated microbes whose active compounds are not known using chromatographic techniques combined with MS by conditioning the type of compounds to be separated and conducting chemical profiles to facilitate a multivariate data analysis.…”

Section: Analytical Methods For Metabolomicsmentioning

confidence: 99%

“…Molecular networking has been used by several recent studies to analyze the metabolomic application on sponges and their associated microbes. The chemical shift profile of the NMR spectroscopy allows it to be analyzed with this molecular networking technique, provided that the available database is sufficient (Fagundes et al, 2021;Ho et al, 2021;Kouchaksaraee et al, 2020;Li et al, 2020).…”

Section: Chemometric Methods For Metabolomicsmentioning

confidence: 99%

See 1 more Smart Citation

Application of metabolomics on marine sponges and sponge-associated microorganisms: A review

Samirana¹,

Jenie²,

Murti³

et al. 2022

j app pharm sci

View full text Add to dashboard Cite

Sponges and their associated microorganisms have tremendous potential in the medical world to be explored. However, improper exploration will cause habitat destruction and cost much. The application of metabolomics to sponges and their associted microbes can be the best solution in their exploration, which involves a combination of chemical profiling and multivariate analysis (chemometrics). In this , we 47 genera of sponges and 24 genera of their associated microorganisms that were studied with a metabolomic approach until July 2021. The sponges most often studied in metabolomics-related research are Geodia, Xestospongia, Agelas, and Aplysina. There are four analytical techniques that are often used, namely, liquid chromatography-mass spectrometry, polymerase chain reaction, nuclear magnetic resonance, and gas chromatography-mass spectrometry, in determining the chemical/genomic profile. There are eight chemometric analyses that are often used in metabolomic applications on sponges and their associated microbes, namely, similarity analysis, principal component analysis, hierarchical cluster analysis, partial least square, partial least square-discriminant analysis, orthogonal projections to latent structures, orthogonal projections to latent structures-discriminant analysis, and linear discriminant analysis. The most widely used metabolomic applications for sponges and their associated microbes for the last decade are for identification and dereplication purposes, for quality control purposes, and for the purpose of linking chemical profiles and bioactivity patterns. The purpose of other metabolomic applications, namely, to determine bioavailability to quantitatively determine bioactivity, and to test safety and toxicity, has yet to be carried out because research on sponges and their associated microbes is still around the discovery of new compounds and quality control.

show abstract

Section: Analytical Methods For Metabolomicsmentioning

confidence: 99%

Section: Chemometric Methods For Metabolomicsmentioning

confidence: 99%

Application of metabolomics on marine sponges and sponge-associated microorganisms: A review

Samirana¹,

Jenie²,

Murti³

et al. 2022

j app pharm sci

View full text Add to dashboard Cite

show abstract

“…For the chemical investigation of natural products, a hyphenated technique of liquid chromatography combined with electrospray ionization high-resolution mass spectrometry (LC-HRMS) has been used for metabolite annotation. Tandem mass spectrometry (MS/MS) with quadrupole time-of-ight (QTOF) mass spectrometer together with global natural product social molecular networking (GNPS) is an effective tool for metabolites dereplication in complex samples such as marine organisms (Nothias et al 2018;Fagundes et al 2021). The chemical ngerprinting of extracts with biological potential is essential in the search for new bioactive metabolites (Allard et al 2017;Mendes et al 2023).…”

Section: )mentioning

confidence: 99%

Antimalarial Potential of a Marine Sponge Tedania Ignis Against Plasmodium Falciparum

Moura,

Annunciato,

Dantas

et al. 2024

Preprint

View full text Add to dashboard Cite

Across the decades, malaria disease has been a public health problem. The use of natural products to treat malaria saved many lives over the centuries, but the parasite resistance against all the medicines available on the market has made it difficult. In this context, exploring new natural treatments from biodiverse ecosystems, such as oceans, holds promise. Marine sponges have been used in different ways to treat diseases, their secondary metabolites and endoperoxides showed antiplasmodial activity in different assays. With that in mind, the species of marine sponge Tedania ignis, was evaluated against sensitive and resistant laboratory P. falciparum strains and presented potential antimalarial activity. Moreover, the speed of action of the extract of T. ignis was assessed demonstrating a fast-active profile. Regarding cellular cytotoxicity assays, the compound under investigation did not exhibit cytotoxic effects on two cell lines: HepG2, derived from human hepatoma, and HEK 293 (Human Embryonic Kidney). The active extract of T. ignis was investigated using UHPLC-HRMS and for data analyses was used Global Natural Products Social Molecular Networking (GNPS). Eight metabolites were dereplicated belonging to classes of alkamides, terpenes, nucleobases, alkaloid, and benzoic acid ester. Among the compounds assigned, dibutyl phthalate is highlighted for its known antimalarial potential, which may contribute to the bioactivity of T. ignis extract revealed in this work.

show abstract

Basic and advanced spectrometric methods for complete nanoparticles characterization in bio/eco systems: current status and future prospects

Borowska

Jankowski

2023

Anal Bioanal Chem

View full text Add to dashboard Cite

The use of engineered nanoparticles in the environment and human life has increased in the last 20 years. The risk assessment concerning application of nanomaterials in biological systems requires their thorough characterization. Understanding the correlations between physicochemical properties of nanoparticles concerning not only the size, particle size distribution, number concentration, degree of aggregation, or agglomeration but also solubility, stability, binding affinity, surface activity, chemical composition, and nanoparticle synthesis yield allows their reliable characterization. Thus, to find the structure-function/property relationship of nanoparticles, multifaceted characterization approach based on more than one analytical technique is required. On the other hand, the increasing demand for identification and characterization of nanomaterials has contributed to the continuous development of spectrometric techniques which enables for their qualitative and quantitative analysis in complex matrices giving reproducible and reliable results. This review is aimed at providing a discussion concerning four main aspects of nanoparticle characterization: nanoparticle synthesis yield, particle size and number concentration, elemental and isotopic composition of nanoparticles, and their surface properties. The conventional and non-conventional spectrometric techniques such as spectrophotometry UV-Vis, mass spectrometric techniques working in conventional and single-particle mode, or those based on optical emission detection systems are described with special emphasis paid on their advantages and drawbacks. The application and recent advances of these methods are also comprehensively reviewed and critically discussed. Graphical abstract

show abstract

Metabolomic fingerprinting of Brazilian marine sponges: a case study of Plakinidae species from Fernando de Noronha Archipelago

Cited by 4 publications

References 30 publications

Application of metabolomics on marine sponges and sponge-associated microorganisms: A review

Application of metabolomics on marine sponges and sponge-associated microorganisms: A review

Antimalarial Potential of a Marine Sponge Tedania Ignis Against Plasmodium Falciparum

Basic and advanced spectrometric methods for complete nanoparticles characterization in bio/eco systems: current status and future prospects

Contact Info

Product

Resources

About