Metabolomic Differences Between Mothers’ Own Breast Milk and Donor Breast Milk

Narasimhan, Sudha Rani; Kinchen, Jason M.; Kifle, Alganesh; Ibclc,; Jegatheesan, Priya; Song, Dongli

doi:10.1542/peds.141.1ma3.272

Cited by 2 publications

(1 citation statement)

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“…The gestational age of a milk donor's infant, and the lactational stage of the milk donor influence milk composition; for instance, mature donor HM composition differs from preterm milk, particularly in fat metabolite concentrations. 34 This is of concern because most donor HM is mature milk. In addition, maternal genetics, dietary factors, milk collection method, and the time of collection are factors that influence milk composition.…”

Section: Hm In the Hospital Settingmentioning

confidence: 99%

Importance of human milk for infants in the clinical setting: Updates and mechanistic links

Nagel,

Elgersma,

Gallagher

et al. 2023

Nut in Clin Prac

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IntroductionHuman milk (HM) is the optimal source of nutrition for infants and has been implicated in multiple aspects of infant health. Although much of the existing literature has focused on the individual components that drive its nutrition content, examining HM as a biological system is needed for meaningful advancement of the field. Investigation of the nonnutritive bioactive components of HM and the maternal, infant, and environmental factors which affect these bioactives is important to better understand the importance of HM provision to infants. This information may inform care of clinical populations or infants who are critically ill, hospitalized, or who have chronic diseases and may benefit most from receiving HM.MethodsIn this narrative review, we reviewed literature examining maternal and infant influences on HM composition with a focus on studies published in the last 10 years that were applicable to clinical populations.ResultsWe found multiple studies examining HM components implicated in infant immune and gut health and neurodevelopment. Additional work is needed to understand how donor milk and formula may be used in situations of inadequate maternal HM. Furthermore, a better understanding of how maternal factors such as maternal genetics and metabolic health influence milk composition is needed.ConclusionIn this review, we affirm the importance of HM for all infants, especially clinical populations. An understanding of how HM composition is modulated by maternal and environmental factors is important to progress the field forward with respect to mechanistic links between HM biology and infant health outcomes.

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Section: Hm In the Hospital Settingmentioning

confidence: 99%

Importance of human milk for infants in the clinical setting: Updates and mechanistic links

Nagel,

Elgersma,

Gallagher

et al. 2023

Nut in Clin Prac

View full text Add to dashboard Cite

show abstract

EBNEO commentary: Early human milk fortification in infants born extremely preterm: A randomised trial

How,

Malhotra,

Martin

2024

Acta Paediatrica

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The aim of this trial (IMPACT-Increased Milk Protein to Accrue Critical Tissue) was to evaluate whether early human milk fortification with a human-derived human milk fortifier resulted in increased fat-free mass (FFM) compared to non-fortified human milk in extremely preterm infants. 1 Authors report on a randomised trial investigating the approach of starting human milk fortification early on enteral feeding Day 2, compared with their practice of feeding unfortified milk until the infant reached full-volume feeding. Though many centres have begun fortifying feedings as early as 40-60 mL/k/day, the intervention in this study, starting with fortified feedings as early as Day 2, is less common and has not been formally studied. The authors found no statistically significant difference in the primary outcome (FFM z-score at term) between the How to cite this article: How HS, Malhotra A, Martin C. EBNEO commentary: Early human milk fortification in infants born extremely preterm: A randomised trial. Acta Paediatr.

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Metabolomic Differences Between Mothers’ Own Breast Milk and Donor Breast Milk

Cited by 2 publications

References 0 publications

Importance of human milk for infants in the clinical setting: Updates and mechanistic links

Importance of human milk for infants in the clinical setting: Updates and mechanistic links

EBNEO commentary: Early human milk fortification in infants born extremely preterm: A randomised trial

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