Metabolomic Characteristics in Endometriosis Patients

Angioni, Stefano; Saponara, Stefania; Succu, Antonio G.; Sigilli, Marco; Scicchitano, Francesco; D’Alterio, Maurizio Nicola

doi:10.1007/978-3-030-57866-4_2

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…This chronic, inflammatory, hormoneinfluenced disorder typically affects women in their reproductive years [1,2]. Recent studies have shown that endometriosis has a wide range of etiological factors, with its origins in genetics, metabolomics, microbiomics, immunology, endocrinology, and particular environmental implication [3][4][5][6][7][8][9]. Endometriosis can clinically appear as microscopic, subtle, typical, cystic ovarian, or deep endometriosis lesions, according to a recent review by Koninckx et al [10].…”

Section: Introductionmentioning

confidence: 99%

Deep Endometriosis and Infertility: What Is the Impact of Surgery?

Daniilidis

Angioni

Michele

et al. 2022

JCM

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In women with deep endometriosis, the spontaneous fertility rate might range from 2 to 10%. The optimal management of these women is still an area of debate. Therefore, this review aims to explore the literature on the impact of deep endometriosis surgery on reproductive outcomes and pregnancy rates in women with and without prior infertility. A total of 392 articles were identified through database searching. Twenty-three studies were eligible to be included in the review. A total of 1548 women were identified, 814 of whom became pregnant, with a mean pregnancy rate of 52.6% (95% CI 49.7–63%). Our review suggests that surgery may improve fertility outcomes. Due to the variability in the studies, it is impossible to stratify fertility outcomes of surgery by the localization of deep endometriosis. More investigations are needed to determine whether surgical management should be first-intention or limited to the failure of medically assisted reproduction treatment.

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