Metabolomic blood test: purpose, implementation and interpretation of data

Abstract

The human body is an open system that receives a variety of xenobiotics in the course of dietary route or respiration and in the form of the drugs. As a lump sum scores of toxic and potentially toxic substances are detected in a human body that significantly affect health and human lifespan. There are also thousands of diseases, dozens of which latently occur in the body of each person. Traditional diagnosis is not able to screen all the variety of xenobiotics and potential human diseases. For this purpose metabolomic blood test is available which is of non-targeted (review) nature. The test can reveal all the diversity of low molecular weight substances in blood, including tens of thousands of xenobiotics and markers of different diseases. Detection of xenobiotics in the blood, directional detoxification and subsequent monitoring of "body's chemical purity" together with the control of "normality" of all biochemical processes in the organism, using metabolomics blood tests is a necessary and presumably a sufficient condition in the implementation of inherent human genotype longevity. This article describes the purpose, implementation and interpretation of metabolomic blood test facilitating the implementation of this method in the Russian Federation, in order to significantly increase the average life expectancy.

Metabolomics Community in Russia: History of Development, Key Participants, and Results

“…This signature is expected to describe global biochemical aberrations that reflect patterns of variance in states of wellness, more accurately describe specific diseases and their progression, and greatly aid in differential diagnosis" [71]. The work of scientists from Russia dedicated to metabolomic blood analysis, human digital imaging, and label-free data standardization for clinical metabolomics is aimed at supporting this initiative [23][24][25].…”

Application of dried blood spot for analysis of low molecular weight fraction (metabolome) of blood

“…The ability to simultaneously detect in the blood the entire set of low-molecular substances, including tens of thousands of xenobiotics and markers of various diseases, can significantly improve a person's health and increase the life span. Metabolomic analysis allows regular monitoring of the "health" of a person, controlling the biochemical processes that occur in the body and providing the opportunity to correct them, which is necessary, and perhaps also a sufficient condition for the realization of the longevity laid down in the human genotype [5].…”

“…At the same time in the body of each person dozens of toxins are present, causing harm to health and reducing the life span of a person. In this connection, a method is needed that makes it possible to identify xenobiotics (characterized by extreme diversity) in the human body [5].…”

“…Without such manifestations, dozens of diseases persist in the body for a long time and covertly, worsening health and shortening the life span of a person. Therefore, a method is needed to identify the entire variety of possible pathological processes in the human body [5].…”

Omics biomarkers and early diagnostics

“…Под постгеномными технологиями обычно подразумевают технологии высокопроизводительного измерения продуктов генной экспрессии -транскриптомику и протеомику. Косвенными продуктами генной экспрессии являются метаболиты, и их анализ -метаболомику -также часто рассматривают в качестве постгеномного метода, хотя, строго говоря, в составе метаболитов человеческого организма немало ксенобиотиков, которые к работе генома прямого отношения не имеют [2].…”