Metabolomic analysis of <i>Lavandula dentata</i> L. and <i>Lavandula stoechas</i> L. extracts by LC-QTOF/MS experiments and multivariate analysis techniques as a chemotaxonomical tool

Palacio, José Pérez-del; Navarro, Caridad Díaz; Martín-Blázquez, Ariadna; González-Olmedo, Carmen; Vergara-Segura, Noemí; Algieri, Francesca; Rodríguez-Nogales, Alba; González-Tejero, M. Reyes; Casares-Porcel, Manuel; Molero-Mesa, Joaquín; Genilloud, Olga; Gálvez, Júlio; Vicente, Francisca

doi:10.1080/11263504.2019.1591536

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…Pérez-del Palacio et al (2020) 59 identified Luteolin 3'-7 diglucoside in the hydroalcoholic extract of L. stoechas using LC-QTOF/MS analysis. This glycosylated flavone is a luteolin analog known for exhibiting potent antioxidant activity 60 and other pharmacological properties, such as anticancer, anti-inflammatory, and neuroprotective effects 60,61 .…”

Section: Discussionmentioning

confidence: 99%

In Vitro Propagation of Algerian Lavandula Stoechas and Assessment of Biochemical Composition and Their Antioxidant Activity

Benyammi,

Krimat,

Alili

et al. 2023

Bulletin of Pharmaceutical Sciences Assiut University

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The present research aimed to investigate the effect of plant growth regulators (PGRs) on the in vitro proliferation of Lavandula stoechas shoots and assessment of the antioxidant potential and total phenolic content of extracts obtained from in vitro cultures and wild plants of L. stoechas, as well as, the chemical analysis of the phenolic content of both extracts carried out using HPLC-DAD. The optimal shoot proliferation and biomass accumulation were achieved with the combination of 0.5 mg/l 6-benzyladenine (BA) and 0.5 mg/l gibberellic acid (GA3). The hydroalcoholic extract obtained from in vitro cultures contained the highest amount of phenolic compounds (83.18 mg GAE/g DW extract) compared to the total phenolic content of wild plants extract (32.33 mg GAE/g DW extract). Furthermore, the hydroalcoholic extract from in vitro cultures exhibited a higher antiradical effect against 2,2-diphenyl-1-picrylhydrazyl (DPPH) with IC50 value of 51.38 ± 0.7µg/ml and higher antioxidant capacity (757.26 mg GAE/g DW) observed by total antioxidant capacity (TAC) assay. The chemical profile of both extracts revealed the presence of naringenin, acacetin, rhamnetin, luteolin 3'-7 diglucoside, and hesperetin. Overall, the results suggest that in vitro cultures of L. stoechas could serve as a potential source for producing active metabolites with high antioxidant properties.

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Section: Discussionmentioning

confidence: 99%

In Vitro Propagation of Algerian Lavandula Stoechas and Assessment of Biochemical Composition and Their Antioxidant Activity

Benyammi,

Krimat,

Alili

et al. 2023

Bulletin of Pharmaceutical Sciences Assiut University

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“…and L. × intermedia cv. super waste of aerial part [22], as well as in L. dentata and L. stoechas through a metabolomic approach [49].…”

Section: Flavonoidsmentioning

confidence: 99%

Lavandula austroapennina (Lamiaceae): Getting Insights into Bioactive Polyphenols of a Rare Italian Endemic Vascular Plant

Gravina

Formato

Piccolella

et al. 2023

IJMS

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Lavandula austroapennina N.G. Passal., Tundis and Upon has recently been described as a new species endemic to the southern Apennines (Italy). Locally, this species has a long ethnobotanical tradition of use for curative and decoration purposes and has been the protagonist of a flourishing essential oil production chain. Currently, while this tradition has long since ended, attention to the species is necessary, with a view to enhancing marginal and rural areas, as a recovery of a precious resource to (i) get insights into its (poly)phenolic fraction and (ii) address new and innovative uses of all its organs in various application fields (e.g., cosmeceutical sector). Therefore, after field sampling and dissection of its organs (i.e., corolla, calyx, leaf, stem and root), the latter, previously deterpenated and defatted, were subjected to accelerated ultrasound extraction and the related alcoholic extracts were obtained. Chemical composition, explored by UHPLC-QqTOF-MS/MS, and the following multivariate data analysis showed that the hydroxycinnamoyl derivatives are abundant in the leaf, stem and root, while flavonoids are more present in corolla and calyx. In particular, coumaroyl flavonoids with glyconic portion containing also hexuronyl moieties differentiated corolla organ, while yunnaneic acid D isomers and esculin distinguished root. When antiradical and reducing properties were evaluated (by means of ABTS, DPPH and PFRAP tests), a similar clustering of organs was achieved and the marked antioxidant efficacy of leaf, stem and root extracts was found. Thus, following cytotoxicity screening by MTT test on HaCaT keratinocytes, the protective effects of the organ extracts were assessed by wound closure observed after the scratch test. In addition, the extracts from corolla, leaf and stem were particularly active at low doses inducing rapid wound closure on HaCaT cells at a concentration of 1 μg/mL. The diversity in (poly)phenols of each organ and the promising bioactivity preliminarily assessed suggest further investigation to be carried out to fully recover and valorize this precious endemic vascular plant.

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Multi-response optimization of extraction yield, total phenols-flavonoids contents, and antioxidant activity of extracts from moroccan Lavandula stoechas leaves: Predictive modeling using simplex-centroid design

Fadil

Lebrazi²,

Aboulghazi³

et al. 2022

Biocatalysis and Agricultural Biotechnology

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Metabolomic analysis of Lavandula dentata L. and Lavandula stoechas L. extracts by LC-QTOF/MS experiments and multivariate analysis techniques as a chemotaxonomical tool

Cited by 5 publications

References 38 publications

In Vitro Propagation of Algerian Lavandula Stoechas and Assessment of Biochemical Composition and Their Antioxidant Activity

In Vitro Propagation of Algerian Lavandula Stoechas and Assessment of Biochemical Composition and Their Antioxidant Activity

Lavandula austroapennina (Lamiaceae): Getting Insights into Bioactive Polyphenols of a Rare Italian Endemic Vascular Plant

Multi-response optimization of extraction yield, total phenols-flavonoids contents, and antioxidant activity of extracts from moroccan Lavandula stoechas leaves: Predictive modeling using simplex-centroid design

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