Metabolomic Alterations in Methotrexate Treatment of Moderate-to-Severe Psoriasis
Yi Zhou,
Yantao Ding,
Mengxing Cui
et al.
Abstract:Background
Aberrant lipid metabolism alterations in skin tissue, blood, or urine have been implicated in psoriasis. Here, we examined lipid metabolites related to psoriasis and their association with the age of disease onset.
Material/Methods
Differences in lipid metabolites before and after methotrexate (MTX) treatment were evaluated. The discovery cohort and validation cohort consisted of 50 and 46 patients, respectively, with moderate-to-severe psoriasis. After MTX t… Show more
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