2020
DOI: 10.1093/femsle/fnaa219
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Metabolome profiles of the alphaproteobacterial methanotroph Methylocystis sp. Rockwell in response to carbon and nitrogen source

Abstract: Methanotrophs use methane as a sole carbon source and thus play a critical role in its global consumption. Intensified interest in methanotrophs for their low-cost production of value-added products and large-scale industrialization has led to investigations of strain-to-strain variation in parameters for growth optimization and metabolic regulation. In this study, Methylocystis sp. Rockwell was grown with methane or methanol as a carbon source and ammonium or nitrate as a nitrogen source. The intracellular me… Show more

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Cited by 11 publications
(10 citation statements)
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“…Moreover, the results confirm that ammonium is the preferred N-source for growth of Methylocystis sp. Rockwell over nitrate or atmospheric nitrogen (Lazic et al 2021;Tays et al 2018), as the final OD of the cultures was highest for the methane-ammonium condition (Figs. 2, 3 and 4).…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the results confirm that ammonium is the preferred N-source for growth of Methylocystis sp. Rockwell over nitrate or atmospheric nitrogen (Lazic et al 2021;Tays et al 2018), as the final OD of the cultures was highest for the methane-ammonium condition (Figs. 2, 3 and 4).…”
Section: Discussionmentioning
confidence: 99%
“…Select branched-chain and aromatic amino acids, which are associated with adaptation to nutrient limitation (4,38), were also upregulated in methanol cultures. Aside from these few exceptions, .…”
Section: Discussionmentioning
confidence: 99%
“…DH-1 grown on methanol (17), including hopanoid biosynthesis, peroxiredoxin, superoxide dismutase, and thioredoxin, though we did not observe the corresponding changes in the oxyR or soxS regulons. Select branched-chain and aromatic amino acids, which are associated with adaptation to nutrient limitation (4, 38), were also upregulated in methanol cultures. Aside from these few exceptions, most central metabolic pathways were downregulated in the presence of methanol: methanol-grown M. album BG8 accumulated fewer carbohydrates, TCA cycle intermediates, and nucleotides, and downregulated several of the genes involved in those pathways.…”
Section: Discussionmentioning
confidence: 99%
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