Metabolites that feed upper glycolytic branches support glucose independent human cytomegalovirus replication
Rebekah L. Mokry,
John G. Purdy
Abstract:The broad tissue distribution and cell tropism of human cytomegalovirus indicates that the virus successfully replicates in tissues with various nutrient environments. HCMV requires and reprograms central carbon metabolism for viral replication. However, many studies focus on reprogramming of metabolism in high nutrient conditions that do not recapitulate physiological nutrient environments in the body. In this study, we investigate how HCMV successfully replicates when nutrients are suboptimal. We limited glu… Show more
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