Metabolites from Marine Microorganisms, Micro, and Macroalgae: Immense Scope for Pharmacology

Barzkar, Noora; Jahromi, Saeid Tamadoni; Poorsaheli, Hadi Bolooki; Vianello, Fábio

doi:10.3390/md17080464

Cited by 121 publications

(82 citation statements)

References 166 publications

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“…Marine microorganisms such as fungi and bacteria are also sources of primary and secondary metabolites with anti-inflammatory activity. The major classes of molecules found in these organisms are peptides and proteins, lipids, polyketides, organic acids, and terpenoids [53][54][55]. Fungi, for example, are the source of a large number of marine alkaloids with known biological activity [50,56].…”

Section: Marine Fungi-and Bacteria-derived Alkaloidsmentioning

confidence: 99%

Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

2020

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Alkaloids are nitrogenous compounds with various biological activities. Alkaloids with anti-inflammatory activity are commonly found in terrestrial plants, but there are few records of the identification and characterization of the activity of these compounds in marine organisms such as fungi, bacteria, sponges, ascidians, and cnidarians. Seaweed are a source of several already elucidated bioactive compounds, but few studies have described and characterized the activity of seaweed alkaloids with anti-inflammatory properties. In this review, we have gathered the current knowledge about marine alkaloids with anti-inflammatory activity and suggest future perspectives for the study and bioprospecting of these compounds.

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Section: Marine Fungi-and Bacteria-derived Alkaloidsmentioning

confidence: 99%

Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

2020

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“…The organic extract was subjected to vacuum liquid chromatography (VLC) eluting with different solvents of increasing polarity from petroleum ether (PE) to MeOH to yield 9 fractions (Fr. [1][2][3][4][5][6][7][8][9].…”

Section: Extraction and Isolationmentioning

confidence: 99%

“…Marine-derived fungi are rich sources of diverse and bioactive secondary metabolites [1,2]. Among them, the species of the genus Penicillium play an important role and have increasingly attracted attention [3].…”

Section: Introductionmentioning

confidence: 99%

Three New Sesquiterpenoids from the Algal-Derived Fungus Penicillium chermesinum EN-480

Yang

et al. 2020

Marine Drugs

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Secondary metabolites obtained from marine-derived fungi are rich sources of drug candidates. Three new sesquiterpenoids, chermesiterpenoids A–C (1–3), along with four known alkaloids (4–7), were isolated and identified from the marine red algal-derived fungus Penicillium chermesinum EN-480. The structures of these new sesquiterpenoids were elucidated using detailed analysis of the NMR data and their relative configurations were elucidated using nuclear overhauser effect spectroscopy (NOESY) spectra as well as gauge-independent atomic orbital (GIAO) NMR shift calculations and DP4+ probability analysis. Their absolute configurations were determined using electronic circular dichroism (ECD) calculations and modified Mosher’s method. Compounds 2 and 3 exhibited potent activities against human and aquatic pathogenic bacteria and plant pathogenic fungi.

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“…Natural products from marine and freshwater microalgae have been widely studied in the last years highlighting their diversified activities, such as antioxidant, antibacterial, antitumor, anti-inflammatory, anti-hypertensive, cardioprotective, and antidiabetic [126,127]. In addition, various studies have used an OSMAC approach in order to increase the production of specific metabolites [5,42,43].…”

Section: Discussionmentioning

confidence: 99%

Microalgae with Immunomodulatory Activities

2019

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Microalgae are photosynthetic microorganisms adapted to live in very different environments and showing an enormous biochemical and genetic diversity, thus representing an excellent source of new natural products with possible applications in several biotechnological sectors. Microalgae-derived compounds have shown several properties, such as anticancer, antimicrobial, anti-inflammatory, and immunomodulatory. In the last decade, compounds stimulating the immune system, both innate immune response and adaptive immune response, have been used to prevent and fight various pathologies, including cancer (cancer immunotherapy). In this review we report the microalgae that have been shown to possess immunomodulatory properties, the cells and the cellular mediators involved in the mechanisms of action and the experimental models used to test immunostimulatory activities. We also report information on fractions or pure compounds from microalgae identified as having immunostimulatory activity. Given the increasing interest in microalgae as new eco-friendly source of bioactive compounds, we also discuss their possible role as source of new classes of promising drugs to treat human pathologies.

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Metabolites from Marine Microorganisms, Micro, and Macroalgae: Immense Scope for Pharmacology

Cited by 121 publications

References 166 publications

Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

Three New Sesquiterpenoids from the Algal-Derived Fungus Penicillium chermesinum EN-480

Microalgae with Immunomodulatory Activities

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