Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants

Durães, Fernando; Szemerédi, Nikoletta; Kumla, Decha; Pinto, Madalena; Kijjoa, Anake; Spengler, Gabriella; Sousa, Emı́lia

doi:10.3390/md19090475

Cited by 18 publications

(11 citation statements)

References 59 publications

(109 reference statements)

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“…The marine environment is a vastly under-exploited area for the discovery of novel EPIs [ 103 ]. Mining the marine environment for such molecules could be beneficial, due to the range of diverse natural products, bioactive compounds already discovered from such environments via metagenomic-based technologies [ 104 ].…”

Section: The Microbial Ecology Of Efflux Inhibition and Sources For E...mentioning

confidence: 99%

Efflux, Signaling and Warfare in a Polymicrobial World

et al. 2023

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The discovery void of antimicrobial development has occurred at a time when the world has seen a rapid emergence and spread of antimicrobial resistance, the ‘perfect storm’ as it has often been described. While the discovery and development of new antibiotics has continued in the research sphere, the pipeline to clinic has largely been fed by derivatives of existing classes of antibiotics, each prone to pre-existing resistance mechanisms. A novel approach to infection management has come from the ecological perspective whereby microbial networks and evolved communities already possess small molecular capabilities for pathogen control. The spatiotemporal nature of microbial interactions is such that mutualism and parasitism are often two ends of the same stick. Small molecule efflux inhibitors can directly target antibiotic efflux, a primary resistance mechanism adopted by many species of bacteria and fungi. However, a much broader anti-infective capability resides within the action of these inhibitors, borne from the role of efflux in key physiological and virulence processes, including biofilm formation, toxin efflux, and stress management. Understanding how these behaviors manifest within complex polymicrobial communities is key to unlocking the full potential of the advanced repertoires of efflux inhibitors.

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Section: The Microbial Ecology Of Efflux Inhibition and Sources For E...mentioning

confidence: 99%

Efflux, Signaling and Warfare in a Polymicrobial World

et al. 2023

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“…Moreover, as is seen with respect to the antimicrobial evaluation of terrestrial secondary metabolites, the antimicrobial evaluation of marine secondary metabolites likewise identifies innumerable structures possessing modest to good antibacterial activity [ 34 ]. Inventories of these structures are published regularly [ 15 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ]. Within these inventories are found structures that are truly distinctive, often in the multiple aspects of their biosynthesis, ring construction, and biological activity.…”

Section: Do Marine Organisms Biosynthesize Exceptional Inhibitors Of ...mentioning

confidence: 99%

β-Lactams from the Ocean

Fisher

Mobashery

2023

Marine Drugs

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The title of this essay is as much a question as it is a statement. The discovery of the β-lactam antibiotics—including penicillins, cephalosporins, and carbapenems—as largely (if not exclusively) secondary metabolites of terrestrial fungi and bacteria, transformed modern medicine. The antibiotic β-lactams inactivate essential enzymes of bacterial cell-wall biosynthesis. Moreover, the ability of the β-lactams to function as enzyme inhibitors is of such great medical value, that inhibitors of the enzymes which degrade hydrolytically the β-lactams, the β-lactamases, have equal value. Given this privileged status for the β-lactam ring, it is therefore a disappointment that the exemplification of this ring in marine secondary metabolites is sparse. It may be that biologically active marine β-lactams are there, and simply have yet to be encountered. In this report, we posit a second explanation: that the value of the β-lactam to secure an ecological advantage in the marine environment might be compromised by its close structural similarity to the β-lactones of quorum sensing. The steric and reactivity similarities between the β-lactams and the β-lactones represent an outside-of-the-box opportunity for correlating new structures and new enzyme targets for the discovery of compelling biological activities.

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“…Secondary metabolites obtained from marine fungi have been particularly interesting, mainly because of their unique chemical structures and biomedical applications [ 8 , 12 ]. In 1949, cephalosporin C was discovered from a culture of Cephalosporium fungus species obtained from the Sardinian coast [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Natural Products from Chilean and Antarctic Marine Fungi and Their Biomedical Relevance

et al. 2023

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Fungi are a prolific source of bioactive molecules. During the past few decades, many bioactive natural products have been isolated from marine fungi. Chile is a country with 6435 Km of coastline along the Pacific Ocean and houses a unique fungal biodiversity. This review summarizes the field of fungal natural products isolated from Antarctic and Chilean marine environments and their biological activities.

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Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants

Cited by 18 publications

References 59 publications

Efflux, Signaling and Warfare in a Polymicrobial World

Efflux, Signaling and Warfare in a Polymicrobial World

β-Lactams from the Ocean

Natural Products from Chilean and Antarctic Marine Fungi and Their Biomedical Relevance

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