Metabolite transport across the mammalian and insect brain diffusion barriers

Weiler, Astrid; Volkenhoff, Anne; Hertenstein, Helen; Schirmeier, Stefanie

doi:10.1016/j.nbd.2017.02.008

Cited by 34 publications

(24 citation statements)

References 297 publications

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“…Using a quantitative assay for a targeted panel of metabolites, we observed a high correlation between relative abundance and precise concentration (r 2~0 .97) for all tested metabolites except Nacetylserine (r 2 =0.63) ( Figure S1H). Overall, these data expand on previous evidence that the metabolomic profile of ASD and TD populations display differences not only in the gut compartment, but also in circulation, which may affect the levels of metabolites throughout the body, including the brain (46,47).…”

Section: J O U R N a L P R E -P R O O Fsupporting

confidence: 82%

Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder

Needham

Adame

Serena

et al. 2021

Biological Psychiatry

135

123

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: J O U R N a L P R E -P R O O Fsupporting

confidence: 82%

Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder

Needham

Adame

Serena

et al. 2021

Biological Psychiatry

135

123

View full text Add to dashboard Cite

show abstract

“…Using a quantitative assay for a targeted panel of metabolites, we observed a high correlation between relative abundance and precise concentration ( Figure S2A). Overall, these data expand on previous evidence that the metabolomic profile of ASD and TD populations display differences not only in the gut compartment, but also in circulation, which may affect the levels of metabolites throughout the body, including the brain (44,45).…”

Section: Plasma and Fecal Metabolomes Differ Between Asd And Tdsupporting

confidence: 82%

Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder

Needham

Adame

Serena

et al. 2020

Preprint

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Autism Spectrum Disorder (ASD) is a neurodevelopmental condition with hallmark behavioral manifestations including impaired social communication and restricted repetitive behavior. In addition, many affected individuals display metabolic imbalances, immune dysregulation, gastrointestinal (GI) dysfunction, and altered gut microbiome compositions. We sought to better understand non-behavioral features of ASD by determining molecular signatures in peripheral tissues. Herein, we present the untargeted metabolome of 231 plasma and 97 fecal samples from a large cohort of children with ASD and typically developing (TD) controls. Differences in lipid, amino acid, and xenobiotic metabolism discriminate ASD and TD samples. We reveal correlations between specific metabolite profiles and clinical behavior scores, and identify metabolites particularly associated with GI dysfunction in ASD. These findings support a connection between GI physiology, metabolism, and complex behavioral traits, and may advance discovery and development of molecular biomarkers for ASD. Sterol 1 1 1 Gly, Ser, Thr 0 1 1

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“…These observations suggest that trehalose is the preferred energy source in the larval brain during fasting, whereas internally stored glycogen plays a more important role in adults. Circulating trehalose is hydrolyzed by Treh in surface glia and is further utilized for energy sources in neurons (Volkenhoff et al, 2015;Weiler et al, 2017). Although the insulin/glucagon axis for carbohydrate metabolism is well conserved in Drosophila, the regulatory systems of Drosophila insulin-like peptide (Dilp) secretion from insulin-producing cells in response to circulating glucose differ significantly between the larval and adult stages (Alfa and Kim, 2016;Nässel and Vanden Broeck, 2016).…”

Section: Discussionmentioning

confidence: 99%

Fat body glycogen serves as a metabolic safeguard for the maintenance of sugar levels in Drosophila

Yamada¹,

Habara²,

Kubo³

et al. 2018

Development

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Adapting to changes in food availability is a central challenge for survival. Glucose is an important resource for energy production, and therefore many organisms synthesize and retain sugar storage molecules. In insects, glucose is stored in two different forms: the disaccharide trehalose and the branched polymer glycogen. Glycogen is synthesized and stored in several tissues, including in muscle and the fat body. Despite the major role of the fat body as a center for energy metabolism, the importance of its glycogen content remains unclear. Here, we show that glycogen metabolism is regulated in a tissue-specific manner under starvation conditions in the fruit fly The mobilization of fat body glycogen in larvae is independent of Adipokinetic hormone (Akh, the glucagon homolog) but is regulated by sugar availability in a tissue-autonomous manner. Fat body glycogen plays a crucial role in the maintenance of circulating sugars, including trehalose, under fasting conditions. These results demonstrate the importance of fat body glycogen as a metabolic safeguard in.

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Metabolite transport across the mammalian and insect brain diffusion barriers

Cited by 34 publications

References 297 publications

Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder

Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder

Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder

Fat body glycogen serves as a metabolic safeguard for the maintenance of sugar levels in Drosophila

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