Metabolite trajectories across the perinatal period and mental health: A preliminary study of tryptophan-related metabolites, bile acids and microbial composition

Kimmel, Mary; Jin, Wanting; Xia, Kai; Lun, Kun; Azcárate-Peril, Andrea; Plantinga, Anna; Wu, Michael C.; Ataei, Shirin; Rackers, Hannah; Carroll, Ian M.; Meltzer‐Brody, Samantha; Fransson, Emma; Knickmeyer, Rebecca

doi:10.1016/j.bbr.2021.113635

Cited by 14 publications

(8 citation statements)

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“…Prenatal stress inhibits the growth and development of neurons [ 14 , 15 , 21 ]. Thus, behind cytokine elevation and neurotransmitters depletion might be the involvement of the tryptophan pathway [ 16 , 22 , 23 ]. There is an interconnection between bacterial shifts [ 17 , 18 , 19 , 20 ] and how microglia respond to environmental stressors in a time- and sex-dependent manner [ 24 , 25 ].…”

Section: Resultsmentioning

confidence: 99%

An Updated Narrative Mini-Review on the Microbiota Changes in Antenatal and Post-Partum Depression

Doroftei

Ilie

Diaconu³

et al. 2022

Diagnostics

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Background: Antenatal depression (AND) and post-partum depression (PPD) are long-term debilitating psychiatric disorders that significantly influence the composition of the gut flora of mothers and infants that starts from the intrauterine life. Not only does bacterial ratio shift impact the immune system, but it also increases the risk of potentially life-threatening disorders. Material and Methods: Therefore, we conducted a narrative mini-review aiming to gather all evidence published between 2018–2022 regarding microflora changes in all three stages of pregnancy. Results: We initially identified 47 potentially eligible studies, from which only 7 strictly report translocations; 3 were conducted on rodent models and 4 on human patients. The remaining studies were divided based on their topic, precisely focused on how probiotics, breastfeeding, diet, antidepressants, exogenous stressors, and plant-derived compounds modulate in a bidirectional way upon behavior and microbiota. Almost imperatively, dysbacteriosis cause cognitive impairments, reflected by abnormal temperament and personality traits that last up until 2 years old. Thankfully, a distinct technique that involves fecal matter transfer between individuals has been perfected over the years and was successfully translated into clinical practice. It proved to be a reliable approach in diminishing functional non- and gastrointestinal deficiencies, but a clear link between depressive women’s gastrointestinal/vaginal microbiota and clinical outcomes following reproductive procedures is yet to be established. Another gut-dysbiosis-driving factor is antibiotics, known for their potential to trigger inflammation. Fortunately, the studies conducted on mice that lack microbiota offer, without a shadow of a doubt, insight. Conclusions: It can be concluded that the microbiota is a powerful organ, and its optimum functionality is crucial, likely being the missing puzzle piece in the etiopathogenesis of psychiatric disorders.

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Section: Resultsmentioning

confidence: 99%

An Updated Narrative Mini-Review on the Microbiota Changes in Antenatal and Post-Partum Depression

Doroftei

Ilie

Diaconu³

et al. 2022

Diagnostics

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“…In the case of pregnant individuals with low SE levels, increased concentrations of B. uniformis might be necessary to compensate the reduction of tryptophan as pregnancy progresses. B. uniformis in combination with fiber intake is also associated with reduced inflammation [ 74 ] and our group has found individuals with history of anxiety may have less dietary fiber intake [ 88 ]. Taken together, it is plausible that a dysregulated microbiota-gut-brain axis due inadequate fiber intake and low levels of SE may lead to higher levels B. uniformis as a compensatory mechanism CXCL11 may reflect a response to a pathogenic microbiome, less tolerance of the fetus or an immune system overreaction during the second trimester, a period characterized by lower inflammation.…”

Section: Discussionmentioning

confidence: 99%

Interactions between perceived stress and microbial-host immune components: two demographically and geographically distinct pregnancy cohorts

et al. 2023

Self Cite

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Higher stress during pregnancy associates with negative outcomes and elevated inflammation. The gut microbiota, reflecting environment and social interactions, alongside host immune responses have the potential to better understand perceived stress and identify when stress is excessive in pregnancy. Two U.S. cohorts of 84 pregnant individuals, composed of urban women of color and suburban white women, completed the Perceived Stress Scale-10 (PSS-10) and provided fecal and blood samples at two time points. Confirmatory Factor Analysis assessed the robustness of a two-factor PSS-10 model (Emotional Distress/ED and Self-Efficacy/SE). Gut microbiota composition was measured by 16 S rRNA amplicon sequencing and the immune system activity was assessed with a panel of 21 T-cell related cytokines and chemokines. ED levels were higher in the suburban compared to the urban cohort, but levels of SE were similar. ED and SE levels were associated with distinct taxonomical signatures and the gut microbiota data improved the prediction of SE levels compared with models based on socio-demographic characteristics alone. Integration of self-reported symptoms, microbial and immune information revealed a possible mediation effect of Bacteroides uniformis between the immune system (through CXCL11) and SE. The study identified links between distinct taxonomical and immunological signatures with perceived stress. The data are congruent with a model where gut microbiome and immune factors, both impacting and reflecting factors such as close social relationships and dietary fiber, may modulate neural plasticity resulting in increased SE during pregnancy. The predictive value of these peripheral markers merit further study.

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“…Also, B. uniformis in combination with fiber intake is associated with reduced inflammation 79 and our group found individuals with history of anxiety may have less dietary fiber intake. 82 High levels of Emotional Distress are associated with elevated levels of anxiety and low levels of Self-Efficacy. Thus, it is plausible that lower diet intake combined with an inadequate microbiota-gut-brain axis due to elevated levels of anxiety and that lower levels of Self-Efficacy may lead to lower levels B. uniformis .…”

Section: Discussionmentioning

confidence: 99%

Interactions between Perceived Stress and Microbial-Host Immune Components in Pregnancy

Bernabé

Maki

Cunningham

et al. 2022

Preprint

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BackgroundHigher stress during pregnancy associates with negative outcomes and elevated inflammation. The gut microbiota reflects the environment, lifestyle, and the perinatal period. The gut microbiota, alongside host immune responses, has the potential to aid in identifying when stress is excessive.MethodsTwo U.S. cohorts, of 84 pregnant individuals, composed of urban women of color and suburban white women, completed the Perceived Stress Scale-10 (PSS-10) and provided fecal and blood samples at two time points. Confirmatory Factor Analysis assessed the robustness of a two-factor PSS-10 (Emotional Distress and Self-Efficacy) in the two cohorts. Gut microbiota composition was measured by 16S rRNA amplicon sequencing and the immune system activity was assessed with a panel of 21 T-cell related cytokines and chemokines.ResultsEmotional Distress levels were higher in the suburban compared to the urban cohort, but levels of Self-Efficacy were similar. Emotional Distress and Self-Efficacy levels were associated with distinct taxonomical signatures and the gut microbiota data improved the prediction of Self-Efficacy levels compared with models based on socio-demographic characteristics alone. Integration of self-reported symptoms, microbial and immune information revealed a possible mediation effect of Bacteroides uniformis between the immune system (through CXCL11) and Self-Efficacy.ConclusionsThe study identified links between distinct taxonomical and immunological signatures with perceived stress. The data is congruent with a model where gut microbiome and immune factors may modulate neural plasticity resulting in increased Self-Efficacy during pregnancy. The predictive value of these peripheral markers merit further study.

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Metabolite trajectories across the perinatal period and mental health: A preliminary study of tryptophan-related metabolites, bile acids and microbial composition

Cited by 14 publications

References 59 publications

An Updated Narrative Mini-Review on the Microbiota Changes in Antenatal and Post-Partum Depression

An Updated Narrative Mini-Review on the Microbiota Changes in Antenatal and Post-Partum Depression

Interactions between perceived stress and microbial-host immune components: two demographically and geographically distinct pregnancy cohorts

Interactions between Perceived Stress and Microbial-Host Immune Components in Pregnancy

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