Metabolite profiling and antioxidative activity of Sage (Salvia fruticosa Mill.) under the influence of genotype and harvesting period

Sarrou, Eirini; Martens, Stefan; Chatzopoulou, Paschalina

doi:10.1016/j.indcrop.2016.08.022

Cited by 61 publications

(46 citation statements)

References 59 publications

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“…The SFM extract had the highest content of phenolics and flavonoids, while the SFD had the lowest. Overall, the values obtained for the determination of the TPC and the TFC revealed a high yield of phenolics and flavonoids, due to the possible presence of rosmarinic acid, carnosol, apigenin, and luteolin, that have been previously identified as the most abundant constituents of SF extracts from the experimental field that our material is originating from [ 23 ].…”

Section: Discussionmentioning

confidence: 71%

Greek Sage Exhibits Neuroprotective Activity against Amyloid Beta-Induced Toxicity

Ververis

Savvidou

Ioannou

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Alzheimer’s disease (AD) is the most common neurodegenerative disease, affecting the elderly at a high incidence. AD is of unknown etiology and currently, no cure is available. Present medication is restricted to treating symptoms; thus, a need exists for the development of effective remedies. Medicinal plants constitute a large pool, from which active compounds of great pharmaceutical potential can be derived. Various Salvia spp. are considered as neuroprotective, and here, the ability of Salvia fruticosa (SF) to protect against toxic effects induced in an AD cell model was partly assessed. Two of AD’s characteristic hallmarks are the presence of elevated oxidative stress levels and the cytotoxic aggregation of amyloid beta (Aβ) peptides. Thus, we obtained SF extracts in three different solvents of increasing polarity, consecutively, to evaluate (a) their antioxidant capacity with the employment of the free radical scavenging assay (DPPH•), of the ferric reducing ability of plasma assay (FRAP), and of the cellular reactive oxygen species assay (DCFDA) and (b) their neuroprotective properties against Aβ25–35-induced cell death with the use of an MTT assay. All three SF extracts showed a considerable antioxidant capacity, with the methanol (SFM) extract being the strongest. The results of the total phenolic and flavonoid contents (TPC and TFC) of the extracts and of the FRAP and the DCFDA assays showed a similar pattern. In addition, and most importantly, the dichloromethane (SFD) and the petroleum ether (SFP) extracts had an effect on Aβ toxicity, exhibiting a significant neuroprotective potential. To our knowledge, this is the first report of SF extracts demonstrating neuroprotective potential against Aβ toxicity. In combination with their antioxidant capacity, SF extracts may be beneficial in combating AD and other neurodegenerative diseases.

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Section: Discussionmentioning

confidence: 71%

Greek Sage Exhibits Neuroprotective Activity against Amyloid Beta-Induced Toxicity

Ververis

Savvidou

Ioannou

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…The effect of season has been investigated by numerous authors, as each plant reacts differently to seasonal changes and different metabolic pathways are responsible for production of the various secondary metabolites in both colder and warmer months (Prinsloo and Nogemane, 2018). Plants such as Rosmarinus officinalis, Salvia fruticose, and Croton heliotropiifolius contain higher concentrations of active compounds in summer and spring months (Lemos et al, 2015;Sarrou et al, 2016;de Alencar Filho et al, 2017). On the contrary many reports described increased activity and active compound levels in the colder months for example Calamintha nepeta, Phillyrea angustifolia, and Thymus longicaulis (Scognamiglio et al, 2014;Pacifico et al, 2015), whereas in some plants seasonal variation does not affect the chemical composition such as in Vaccinium myrtillus (Bujor et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

1H-NMR Metabolomics and LC-MS Analysis to Determine Seasonal Variation in a Cosmeceutical Plant Leucosidea sericea

2020

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Leucosidea sericea is an evergreen shrub belonging to the Rosaceae family with previous studies that indicated that L. sericea extracts exhibited strong anti-bacterial properties against Propionibacterium acnes, showing potential as a cosmeceutical. The plant is traditionally used as a vermifuge, as an astringent and to treat conjunctivitis. Commercial production is, however, not possible as no information is available on cultivation and the effect of external environmental factors such as seasonal variation on the medicinal properties of the plant. Seasonal variation was investigated and it was found that significant differences were observed between the anti-acne (P. acnes) activity of plant material collected in different seasons. The best activity was found in winter with a mean minimum inhibitory concentration (MIC) of 5.20 µg mL −1 compared to spring at 26.04 µg mL −1. A 1 H NMR-based untargeted metabolomic analysis was used to determine the differences in the chemical profiles of plant samples collected in different seasons. Principal component analysis (PCA) showed clear separation of the seasons and a supervised orthogonal partial least square discriminant analysis (OPLS-DA) was used to determine the compounds that differentiated the spring from the winter samples. The contribution plot indicated a strong positive association with the NMR regions from δ 1.2-1.6, 3.3-4.1, and 6.8-8.0 ppm indicative of a compound with an aromatic ring. Different LC-MS analyses were used in conjunction with a compound database, MAGMa and CSIFingerID, which led to the identification of the compound 2-(4-ethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one and also confirmed the presence of tangeritin, rutin, quercetin glucoside, and kaempferol glucosides as well as several other compounds previously identified from the plant. This compound similar in structure to the anti-microbial flavonoid tangeritin, was only present in the winter samples. It is therefore recommended that seasonal variation be closely monitored during cultivation and commercial harvesting, and that winter is the preferred harvesting season to obtain the best anti-acne activity.

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“…Biodiversity 2020, 17, e1900677 www.cb.wiley.com (12 of 53) e1900677 quality of L. angustifolia EO is positively regulated by temperature and flowering stage development while it was negatively affected by rainfall during flowering period because the remarkable decline of linalool production. [157] Recent studies show that early-summer or summer is the best harvest period for S. fruticosa [158] and S. officinalis, [159] for which flowering period as best phenological phase is confirmed, [160] as per as for S. verbenaca. [161] The seasonal variation showed significant effects in the composition of the essential oils of R. officinalis with a greater amount of the oil and the main components in the summer.…”

Section: S Algeriensismentioning

confidence: 99%

New Tricks for Old Guys: Recent Developments in the Chemistry, Biochemistry, Applications and Exploitation of Selected Species from the Lamiaceae Family

Napoli

Siracusa

Ruberto

2020

Chemistry & Biodiversity

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Lamiaceae is one of the largest families of flowering plants comprising about 250 genera and over 7,000 species. Most of the plants of this family are aromatic and therefore important source of essential oils. Lamiaceae are widely used as culinary herbs and reported as medicinal plants in several folk traditions. In the Mediterranean area oregano, sage, rosemary, thyme and lavender stand out for geographical diffusion and variety of uses. The aim of this review is to provide recent data dealing with the phytochemical and pharmacological studies, and the more recent applications of the essential oils and the non‐volatile phytocomplexes. This literature survey suggests how the deeper understanding of biomolecular processes in the health and food sectors as per as pest control bioremediation of cultural heritage, or interaction with human microbiome, fields, leads to the rediscovery and new potential applications of well‐known plants.

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Metabolite profiling and antioxidative activity of Sage (Salvia fruticosa Mill.) under the influence of genotype and harvesting period

Cited by 61 publications

References 59 publications

Greek Sage Exhibits Neuroprotective Activity against Amyloid Beta-Induced Toxicity

Greek Sage Exhibits Neuroprotective Activity against Amyloid Beta-Induced Toxicity

1H-NMR Metabolomics and LC-MS Analysis to Determine Seasonal Variation in a Cosmeceutical Plant Leucosidea sericea

New Tricks for Old Guys: Recent Developments in the Chemistry, Biochemistry, Applications and Exploitation of Selected Species from the Lamiaceae Family

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