Metabolite Profiling and Antimicrobial Activity of Aloe greatheadii var. Davyana against Bacterial Illness

Abstract

The aim of the study was to profile the metabolite content of Aloe greatheadii and investigate their antibacterial potential against illness causing bacteria. The metabolite profile of A. greatheadii was determined and the antibacterial activity tested against Gram-positive and Gram-negative bacteria. The metabolite profile resolved on TLC plates indicated an almost similar pattern of bands for majority of the separated compounds. The results on the maximum absorption wavelength of extracts from all locations ranged between 240 and 320 nm. The most susceptible bacteria for the treatment by samples from all the provinces was the Gram-positive E. faecalis with MIC values ranging from 0.54 to 0.067 mg/mL. It was interesting to note that susceptibility of the tested bacteria to treatment by the plant extracts was not specific to either Gram-positive or Gram-negative bacteria.