Metabolite analysis and anti-obesity effects of celery seed in 3T3-L1 adipocytes

Kim, Mi‐Ja; Lee, Hyun-Jong; Bae, Hyun-Gyeong; Yang, Seung-Ok; Lee, Hee Jae

doi:10.1007/s10068-020-00866-9

Cited by 9 publications

(3 citation statements)

References 33 publications

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“…Celery seed oil inhibits adipocyte differentiation through the downregulation of adipogenic genes such as Fatty acid synthase (FAS). In addition, celery oil suppresses the production of lipids and the synthesis of adipocyte hormones (leptin and adiponectin) that play an important biochemical role in adipogenesis (Kim et al, 2021). As shown in our result, celery seed oil significantly reduced cardiac TG and FFA content.…”

Section: Correlation Studiessupporting

confidence: 75%

Ameliorative effect of celery seed oil against high-fat diet-induced lipotoxic heart disease in rats

Salem,

Mahmoud,

Shaker

et al. 2024

Biological and Biomedical Journal

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Obesity is a risk factor for heart disease. Persistent exposure to excess lipids in the circulation can harm the heart by accumulating hazardous metabolic byproducts such as reactive oxygen species and ceramides, which can cause myocyte malfunction and death by activating signaling pathways. Herbs are one of the most popular weight-loss alternative medicines in the world. Our study aimed to evaluate the possible effects of celery seed oil against high-fat diet-induced lipotoxicity of heart in rats. The study was conducted on 40 male Wistar rats that were classified into 2 groups. Group I (GpI) served as control. GpII was obese rats, subdivided into four subgroups (untreated, treated with orlistat drug, celery seed oil, and a combination of celery seed oil /orlistat drug. At the end of treatment, all rats were scarified, blood samples and heart tissues of the rats were collected. Celery seed oil showed ameliorative effect against high-fat diet-induced lipotoxic heart disease through multiple interrelated mechanisms including alleviation the histological changes, boosting the antioxidant status, improving lipid profile, and reducing fatty acid accumulation in cardiac tissue. The treatment with a combination of celery seed oil /orlistat drug showed the best effect. In conclusion, celery seed oil could be used for the protection against obesity alone or used as adjuvant with orlistat drugs to enhance their pharmacological effect against lipotoxic heart disease.

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Section: Correlation Studiessupporting

confidence: 75%

Ameliorative effect of celery seed oil against high-fat diet-induced lipotoxic heart disease in rats

Salem,

Mahmoud,

Shaker

et al. 2024

Biological and Biomedical Journal

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“…Elevated rates of inflammation have been shown to predispose the development of diabetes, and the antioxidant effects of celery compounds may counteract this [ 91 , 92 ]. Additionally, luteolin in celery has been shown in vitro to enhance insulin action through the increased expression of peroxisome proliferator-activated receptor γ (PPARγ) and decreased TNF-α mRNA levels [ 93 ].…”

Section: Influence Of Root Vegetables On Healthmentioning

confidence: 99%

Root Vegetables—Composition, Health Effects, and Contaminants

Knez

Kadac-Czapska

Dmochowska-Ślęzak

et al. 2022

IJERPH

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Root vegetables are known all over the world, but they are being less and less consumed by individuals. The main purpose of this article was to summarize the benefits, health effects, and threats associated with the consumption of carrot, celery, parsley, beetroot, radish, turnip, and horseradish. They are characterized by high nutritional value due to their richness in dietary fiber, vitamins, and minerals. One of their most important features is their high content of bioactive compounds, such as polyphenols, phenols, flavonoids, and vitamin C. These compounds are responsible for antioxidant potential. Comparison of their antioxidant effects is difficult due to the lack of standardization among methods used for their assessment. Therefore, there is a need for a reference method that would allow for correct interpretation. Moreover, root vegetables are characterized by several health-promoting effects, including the regulation of metabolic parameters (glucose level, lipid profile, and blood pressure), antioxidant potential, prebiotic function, and anti-cancer properties. However, due to the type of cultivation, root vegetables are vulnerable to contaminants from the soil, such as toxic metals (lead and cadmium), pesticides, pharmaceutical residues, microplastics, and nitrates. Regardless, the low levels of toxic substances present in root vegetables do not pose health risks to the average consumer.

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“…Immature persimmon fruit exhibits astringency due to the presence of tannins called kaki-tannin ( Matsuo and Ito, 1978 ). Tannins have been reported to inhibit lipid droplet formation and stimulate lipolysis by increasing glycerol release in the 3T3-L1 adipocyte ( Kim et al, 2008 ; Shin et al, 2014 ). Furthermore, a previous study demonstrated that supplementation with tannins tended to decrease body weight and liver lipids in an HFD-fed animal ( Yugarani et al, 1992 ).…”

Section: Resultsmentioning

confidence: 99%

Immature Persimmon (Diospyros kaki Thunb.) Ethanol Extract Ameliorates High-Fat Diet-Induced Obesity by Modulating Lipid Metabolism

Yoon,

Ham,

Han

et al. 2023

Prev. Nutr. Food Sci.

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In this study, immature persimmon ( Diospyros kaki Thunb.) ethanol extract was administered to an obese animal model fed a high-fat diet to measure weight change, adipose tissue weight, serum lipid level, and expression level of adipose-related genes to evaluate its efficacy. Administration of D. kaki ethanol extract (DKE) (100 and 500 mg/kg/d) decreased the body weight gain, adipose tissue weight, and serum triglyceride levels in mice fed a high-fat diet. Furthermore, it improved the leptin and adiponectin levels in the blood as well as gene expression in the liver. It also inhibited the expression of sterol regulatory element-binding protein-1c, inhibiting the production of triglyceride biosynthetic enzyme fatty acid synthesis and acetyl-CoA carboxylase, and decreased the expressions of peroxisome proliferator-activated receptor γ and CCAAT/enhancer-binding proteins that induce adipocyte differentiation. Therefore, these data suggest that DKE exerts beneficial effects on high-fat diet-induced obesity by modulating lipid metabolism in mice fed a high-fat diet.

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Metabolite analysis and anti-obesity effects of celery seed in 3T3-L1 adipocytes

Cited by 9 publications

References 33 publications

Ameliorative effect of celery seed oil against high-fat diet-induced lipotoxic heart disease in rats

Ameliorative effect of celery seed oil against high-fat diet-induced lipotoxic heart disease in rats

Root Vegetables—Composition, Health Effects, and Contaminants

Immature Persimmon (Diospyros kaki Thunb.) Ethanol Extract Ameliorates High-Fat Diet-Induced Obesity by Modulating Lipid Metabolism

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