Metabolismo mineral en niños en diálisis peritoneal crónica

O, María Luisa Ceballos; L, Angélica Rojo; P, Marta Azócar; M, María José Ibacache; B, Angela Delucchi; Z, Lily Quiroz; M, Carlos Irarrázabal; B, Iris Delgado; P, Francisca Ugarte; Sch, Francisco Cano

doi:10.4067/s0370-41062014000100004

Cited by 1 publication

(2 citation statements)

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“…In a previous study of the research team as well as in the patients of this study, FGF23 values in children with CKD on PD were found to be significantly higher than the mean value observed in the control group of healthy children. The Klotho cofactor analysis showed lower values than the control group, and no association with FGF23 or with other biochemical variables studied were found 28 . Sugiura et al, measured the expression of soluble Klotho using an ELISA kit in patients with CKD and in controls, confirming that this protein has decreased levels in uremic patients 29 .…”

Section: Discussionmentioning

confidence: 94%

“…FGF23 decreases phosphate reabsorption in the proximal tubule by reducing the expression of sodium-phosphate cotransporter 2a (NaPi-2a) in the apical membrane, generating phosphaturia and suppressing the Cyp27b1 gene encoding 1 a-hydroxylase enzyme, responsible for the second hydroxylation and activation of 25 (OH) vit D3. Igualmente, aumenta la expresión del gen Cyp24 que codifica para 24-hidroxilasa, enzima que inactiva la vitamina D 27,28 . In a previous study of the research team as well as in the patients of this study, FGF23 values in children with CKD on PD were found to be significantly higher than the mean value observed in the control group of healthy children.…”

Section: Discussionmentioning

confidence: 99%

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Eje somatotrópico y marcadores moleculares del metabolismo mineral en niños en diálisis peritoneal crónica

Osorio

Schuffeneger

2016

Revista Chilena de Pediatría

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Eje somatotrópico y marcadores moleculares del metabolismo mineral en niños en diálisis María Luisa Ceballos Osorio, Francisco Cano Schuffeneger AbstractGrowth failure is one of the most relevant complications in children with chronic kidney disease (CKD). Among others, growth hormone (GH) resistance and bone mineral disorders have been identified as the most important causes of growth retardation. Objectives: 1. To characterize bone mineral metabolism and growth hormone bio-markers in CKD children treated with chronic peritoneal dialysis (PD). 2. To evaluate height change with rhGH treatment. Patients and Method: A longitudinal 12-month follow-up in prepuberal PD children. Exclusion criteria: Tanner stage > 1, nephrotic syndrome, genetic disorders, steroids, intestinal absorption disorders, endocrine disturbances, treatment with GH to the entry of the study. Demographic and anthropometric data were registered. FGF23, Klotho, VitD, IGF-1, IGFBP3, and GHBP were measured to evaluate mineral and growth metabolism. Results: 15 patients, 7 male, age 6.9 ± 3.0 y were included. Time on PD was 14.33 ± 12.26 months. Height/age Z score at month 1 was -1.69 ± 1.03. FGF23 and Klotho: 131.7 ± 279.4 y 125.9 ± 24.2 pg/ml, respectively. 8 patients were treated with GH during 6-12 months, showing a non-significant increase in height/age Z-score during the treatment period. Bivariate analysis showed a positive correlation between Klotho and delta ZT/E, and between GHBP vs growth velocity index (p < .05). Conclusions: FGF23 values were high and Klotho values were reduced in children with CKD in PD, comparing to healthy children. Somatotropic axis variables were normal or elevated. rhGH tends to improve height and there is a positive correlation of GHBP and growth velocity in these children.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%