Metabolismo Do Lactato E Avaliação De Desempenho: Dois Lados Do Mesmo Processo

Furlan, Julia Pedrosa; Depieri, André Luiz Veronez; Pedrosa, Maria Montserrat Diaz

doi:10.17765/1983-1870.2017v10n1p171-179

Cited by 3 publications

(8 citation statements)

References 12 publications

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“…In other words, by intensifying the conversion of lactate to glucose, the liver of group T8 kept blood lactate steady while muscle strength increased. This is precisely the expected relationship in an assessment of performance [7].…”

Section: Discussionsupporting

confidence: 68%

“…These results indicate that resistance HIIT for 8 weeks, in addition to its effects on physical performance, also conditions the energy metabolism of the liver, making it a more efficient gluconeogenic organ. Trained individuals need larger stores of muscle glucose, especially for high-intensity activities [7]. To accomplish this, the liver needs to be more prepared to metabolize the blood lactate (produced by skeletal muscle during high-intensity exercise).…”

Section: Discussionmentioning

confidence: 99%

“…Blood lactate is altered as a function of exercise type, duration and intensity; the level of training of the individual is influential as well [4]. Blood lactate is used for the assessment of aerobic capacity because it is a residual product of glycolysis that is easily measured and has a high correlation with exercise performance [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…In general, the blood lactate of a subject increases exponentially from a certain exercise intensity, known as lactate threshold or anaerobic threshold [7]. In practical terms, this means that well-trained individuals have the anaerobic threshold at higher exercise intensities than less trained or sedentary subjects.…”

Section: Introductionmentioning

confidence: 99%

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Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice

Müller¹

2019

AJSS

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High-intensity interval training (HIIT) markedly activates muscle anaerobic glycolysis and increases blood lactate.As the liver is a major organ for lactate clearance from the bloodstream, it might improve gluconeogenesis from lactate (NEO-lac) after a period of resistance HIIT. NEO-lac was evaluated by in situ liver perfusion in mice subjected to a resistance HIIT for 4 (T4) or 8 (T8) weeks, or not trained (T0). Perfusion was carried out immediately after an incremental exercise session to test the acute NEO-lac. Muscle strength (expressed as relative maximum load) and blood lactate were higher in T4 than in T0, but NEO-lac did not differ, possibly because of energy discharge of the liver and substrate overload. After 8 weeks of HIIT (T8), both muscle strength and liver NEO-lac increased, but blood lactate did not. The resistance HIIT for 8 weeks modulated liver gluconeogenic efficiency and capacity, which are important mechanisms for the improved clearance of blood lactate.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice

Müller¹

2019

AJSS

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“…O lactato absorvido no rúmen é metabolizado no fígado, que por sua vez têm importante papel na remoção do lactato da corrente sanguínea. O papel do lactato nesse órgão é ser uma fonte principal de carbono para a gliconeogênese, processo pelo qual moléculas como lactato, glicerol e aminoácidos são convertidas a glicose (Furlan et al, 2017). É importante ainda levar em consideração que concentrações plasmáticas de glicose elevadas levam ao desenvolvimento de degenerações crônicas associadas à falência de diversos órgãos, principalmente olhos, rins, coração, nervos e vasos sanguíneos .…”

Section: Resultsunclassified

Melão in natura como dieta exclusiva para bovinos: um estudo de caso

Melo

Batista

Pinto

et al. 2020

RSD

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Objetivou-se estudar o efeito da utilização do melão in natura como dieta exclusiva para bovinos de corte, observando os efeitos dessa dieta sobre parâmetros bioquímicos e histologia hepática. Para a análise dos parâmetros séricos as concentrações plasmáticas de glicose, fosfatase alcalina, AST (aspartato aminotransferase), ALT (alanina aminotransferase) e ureia foram determinadas utilizando os sistemas de análises bioquímicas ADVIA 1800® e Hitachi 917®. As análises microscópicas (concentração de glicogênio e histopatologia hepática) foram efetuadas em microscópio ótico, com aumento de 40x (Olympus CX31, Olympus Ótica Co, Japão). Os valores dos metabólitos sangüíneos estavam dentro da normalidade para a espécie com exceção da taxa de glicose, que apresentou valores variando de 130,33 a 171,50 mg / dL, acima dos valores normais. A histologia hepática mostrou danos leves e acúmulo de glicogênio, condições decorrentes de uma dieta rica em carboidratos solúveis. A dieta exclusiva de melão é uma alternativa para substituir parte da dieta de bovinos de corte, é importante observar a adaptação dos animais à dieta e o tempo a que serão submetidos a ela.

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High-intensity interval resistance training (HIIRT) improves liver gluconeogenesis from lactate in Swiss mice

Müller

Matos

Perego

et al. 2022

Appl. Physiol. Nutr. Metab.

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High-intensity physical exercise favors anaerobic glycolysis and increases lactatemia. Lactate is converted back to glucose in the liver, so that the lactate threshold, an indicator of physical performance, must be related to the gluconeogenic capacity of the liver. This research assessed the effect of a high-intensity interval resistance training (HIIRT) on liver gluconeogenesis from lactate. Swiss mice were trained (groups T) on vertical ladder with overload of 90% of their maximal load. Control animals remained untrained (groups C0 and C8). In situ liver perfusion with lactate and adrenaline was performed in rested mice after six hours of food deprivation. There were larger outputs of glucose (T6 71.90%, T8 54.53%) and pyruvate (T8 129.28%) (representative values for 4 mM lactate) in the groups trained for six or eight weeks (T6 and T8), and of glucose in the presence of adrenaline in group T8 (280%). The content of PEPCK, an important regulatory enzyme of the gluconeogenic pathway, was 69.13% higher in group T8 than in the age-matched untrained animals (C8). HIIRT augmented liver gluconeogenesis from lactate and this might improve the lactate threshold. Bullet points: The liver metabolizes lactate from muscle into glucose. Physical training may enhance the gluconeogenic capacity of the liver. As lactate clearance by the liver improves, lactate threshold is displaced to higher exercise intensities.

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Metabolismo Do Lactato E Avaliação De Desempenho: Dois Lados Do Mesmo Processo

Cited by 3 publications

References 12 publications

Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice

Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice

Melão in natura como dieta exclusiva para bovinos: um estudo de caso

High-intensity interval resistance training (HIIRT) improves liver gluconeogenesis from lactate in Swiss mice

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