Metabolism, Toxicity and Manner of Action of Gold Compounds Used in the Treatment of Arthritis. I. Human Plasma and Synovial Fluid Concentration and Urinary Excretion of Gold During and Following Treatment With Gold Sodium Thiomalate, Gold Sodium Thiosulfate, and Colloidal Gold Sulfide

Chemotactic factor‐induced generation of superoxide radicals by human neutrophils

“…Indomethacin, ibuprofen, and phenylbutazone all demonstrated substantial, dose-dependent inhibition of superoxide production at concentrations comparable to those plasma and tissue levels obtained in patients taking therapeutic doses of the drugs (34-37). In contrast, acetylsalicylic acid and aurothioglucose had negligible effects on superoxide generation at pharmacologic concentrations obtained in vivo (38,39). FMLPinduced superoxide generation appeared relatively insensitive to hydrocortisone (IDSo > 10-3M).…”

Gold metabolism in patients with rheumatoid arthritis treated with gold compounds—reinvestigated

“…That statement holds true to date. However, over the years, significant contributions have been made to the understanding of metabolism of gold compounds in both animals and humans (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

Aurothiomalate inhibits the expression of mPGES-1 in primary human chondrocytes

“…Methotrexate, sulfasalazine and hydroxychloroquine (triple therapy) were selected to this design because using them with a small dose of glucocorticoid as a combination therapy is evidently more effective treatment in RA than using a single DMARD with or without a small daily dose of glucocorticoid (14). The above mentioned combination is also recommended in the A selective inhibition of PGE 2 formation might be an effective manner to treat many types of pain with less adverse effects as compared to NSAIDs.…”