Metabolism of Tissues Excised From Thyroxine-Injected Rats

Barker, S. B.; Klitgaard, H. M.

doi:10.1152/ajplegacy.1952.170.1.81

Cited by 235 publications

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“…The most prominent effects of T $ on ANT2 mRNA expression were observed in heart and liver, whereas weak or no responses occurred in kidney and brain. This tissue-specific T $ response on ANT mRNA shows a striking similarity to the tissue-specific changes in respiratory metabolism [1,2] and thus suggests that ANT2 is important in modulating T $ -induced oxygen consumption.…”

Section: Discussion Expression and T 3 -Dependent Regulation Of Antmentioning

confidence: 67%

“…T $ administration to rats leads to a marked increase in oxygen consumption after 36-72 h in tissues such as heart, liver and kidney, whereas no effects occur in spleen, testes and adult brain (see, for example, [1]). This stimulation of respiration seems to be the result of an increased capacity of both the respiratory chain and oxidative phosphorylation [2].…”

Section: Introductionmentioning

confidence: 99%

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Regulation of adenine nucleotide translocase and glycerol 3-phosphate dehydrogenase expression by thyroid hormones in different rat tissues

Dümmler

Müller

Seitz

1996

Biochemical Journal

107

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Thyroid hormone (T $ )-dependent gene expression of the adenine nucleotide translocase (ANT) and the FAD-linked glycerol 3-phosphate dehydrogenase (mGPDH) was investigated in several rat tissues. Both proteins provide an important link between cytosolic and mitochondrial metabolic pathways and seem to be involved in the stimulation of mitochondrial oxygen consumption in response to T $ . Here we show that two ANT isoforms are expressed in rat, the muscle-specific ANT1 form and the ubiquitous ANT2 form. The expression of ANT1 mRNA is not sensitive to T $ whereas the amount of ANT2 mRNA is increased 7-9-fold in liver and heart within 12-48 h after T $ application. Little or no effect of T $ on ANT2 mRNA was observed in kidney and brain. The mRNA changes are paralleled by an increase in ANT protein, thus explaining the accelerated ADP\ATP exchange observed in mitochondria isolated from hyperthyroid rats. The key role of ANT2 in the control of hyperthyroid

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Section: Discussion Expression and T 3 -Dependent Regulation Of Antmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Regulation of adenine nucleotide translocase and glycerol 3-phosphate dehydrogenase expression by thyroid hormones in different rat tissues

Dümmler

Müller

Seitz

1996

Biochemical Journal

107

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“…Nevertheless, for many years, the impact of thyroid disorders on male reproduction remained controversial. Early studies in the 1950's demonstrated that testes were essentially independent of thyroid hormone effects (1,2). For this reason, the potential of thyroid hormone in the modulation of male reproductive function was not determined.…”

Section: Introductionmentioning

confidence: 99%

Clinical implications of altered thyroid status in male testicular function

Wajner

Wagner

Maia

2009

Arq Bras Endocrinol Metab

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Thyroid hormones are involved in the development and maintenance of virtually all tissues. Although for many years the testis was thought to be a thyroid-hormone unresponsive organ, studies of the last decades have demonstrated that thyroid dysfunction is associated not only with abnormalities in morphology and function of testes, but also with decreased fertility and alterations of sexual activity in men. Nowadays, the participation of triiodothyronine (T3) in the control of Sertoli and Leydig cell proliferation, testicular maturation, and steroidogenesis is widely accepted, as well as the presence of thyroid hormone transporters and receptors in testicular cells throughout the development process and in adulthood. But even with data suggesting that T3 may act directly on these cells to bring about its effects, there is still controversy regarding the impact of thyroid diseases on human spermatogenesis and fertility, which can be in part due to the lack of well-controlled clinical studies. The current review aims at presenting an updated picture of recent clinical data about the role of thyroid hormones in male gonadal function. RESUMOOs hormônios da tireoide estão envolvidos virtualmente no desenvolvimento e na manutenção de todos os tecidos. As gônadas masculinas foram, por décadas, consideradas insensíveis aos hormônios tireoidianos. No entanto, estudos mais recentes têm demonstrado que disfunções tireoidianas estão associadas não somente a anormalidades na morfologia e na função dos testículos, mas também à diminuição da fertilidade e alterações na atividade sexual masculina. Atualmente, o papel da triiodotironina (T3) no controle da proliferação das células de Sertoli e Leydig, maturação testicular e esteroidogênese é amplamente aceito, bem como a presença de transportadores e receptores para o hormônio tireoidiano nos testículos durante o período de desenvolvimento e a idade adulta. No entanto, apesar dos dados que indicam que o T3 atua diretamente nos testículos humanos, persistem controvérsias em relação ao impacto das doenças tireoidianas sobre a espermatogênese e a fertilidade, o que pode ser em parte devido à escassez de estudos clínicos nessa área. Essa revisão tem por objetivo apresentar um panorama de dados clínicos atualizados sobre o papel dos hormônios tireoidianos na função gonadal masculina. Arq Bras Endocrinol Metab. 2009;53(8):976-82 Descritores

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“…In fact, the development of a hyperthyroid state in vertebrates leads to an increase in their metabolic rate due to an enhanced rate of O 2 consumption in most of body tissues (Barker and Klitgaard, 1952). Although thyroxine (T 4 ) is the main product of thyroid secretion is widely shared the view that T 4 is only a prohormone and must be activated by deiodination to triiodothyronine (T 3 ) in order to initiate thyroid hormone action.…”

Section: Introductionmentioning

confidence: 99%

Involvement of PGC-1, NRF-1, and NRF-2 in metabolic response by rat liver to hormonal and environmental signals

Venditti

Bari

Stefano

et al. 2009

Molecular and Cellular Endocrinology

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 AbstractWe studied liver oxidative capacity and O 2 consumption in hypothyroid rats treated for 10 days with T 4 , or T 3 , or treated for 10 days with T 3 and exposed to cold for the last two days. The metabolic response of homogenates and mitochondria indicated that all treatments increased the synthesis of respiratory chain components, whereas only the cold induced mitochondrial proliferation. Determination of mRNA and protein expression of transcription factor activators, such as NRF-1 and NRF-2, and coactivators, such as PGC-1, showed that mRNA levels, except PGC-1 ones, were not related to aerobic capacities. Conversely, a strong correlation was found was between cytochrome oxidase activity and PGC-1 or NRF-2 protein levels.Such a correlation was not found for NRF-1. Our results strongly support the view that in rat liver PGC-1 and NRFs are responsible for the iodothyronine-induced increases in respiratory chain components, whereas their role in cold-induced mitochondrial proliferation needs to be further on clarified.

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Metabolism of Tissues Excised From Thyroxine-Injected Rats

Cited by 235 publications

References 0 publications

Regulation of adenine nucleotide translocase and glycerol 3-phosphate dehydrogenase expression by thyroid hormones in different rat tissues

Regulation of adenine nucleotide translocase and glycerol 3-phosphate dehydrogenase expression by thyroid hormones in different rat tissues

Clinical implications of altered thyroid status in male testicular function

Involvement of PGC-1, NRF-1, and NRF-2 in metabolic response by rat liver to hormonal and environmental signals

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