Metabolism of the glutamate group of amino acids in rat brain as a function of age

Rajeswari, T.S.; Radha, E.

doi:10.1016/0047-6374(84)90066-6

Cited by 20 publications

(1 citation statement)

References 24 publications

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“…At present, the role of pyrimidine metabolism in the aging process remains to be further defined. In addition, some scholars have studied the metabolic changes in the levels of glutamate groups (glutamic acid, gamma-aminobutyric acid, glutamine, aspartic acid and alanine) in the rat brain, and the results show that the changes in the levels of these amino acids are related to aging ( Rajeswari and Radha, 1984 ). Glycerophospholipids are amphiphilic molecules that play important roles in functions such as nerve cell membranes, receptors, transporters, ion channels, and reservoirs for lipid mediators.…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein E knockout may affect cognitive function in D-galactose-induced aging mice through the gut microbiota–brain axis

Chen

et al. 2022

Front. Neurosci.

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The gut microbiota plays an important role in central nervous system (CNS) disorders. Apolipoprotein E (ApoE) can affect the composition of the gut microbiota and is closely related to the CNS. However, the mechanism by which ApoE affects cognitive dysfunction through the gut microbiota–brain axis has thus far not been investigated. In this study, we used wild-type mice and ApoE knockout (ApoE–/–) mice to replicate the aging model and examined the effects of ApoE deletion on cognitive function, hippocampal ultrastructure, synaptophysin (SYP) and postsynaptic density 95 (PSD-95) in aging mice. We also explored whether ApoE deletion affects the gut microbiota and the metabolite profile of the hippocampus in aging mice and finally examined the effect of ApoE deletion on lipids and oxidative stress in aging mice. The results showed that the deletion of ApoE aggravated cognitive dysfunction, hippocampal synaptic ultrastructural damage and dysregulation of SYP and PSD-95 expression in aging mice. Furthermore, ApoE deletion reduced gut microbial makeup in aging mice. Further studies showed that ApoE deletion altered the hippocampal metabolic profile and aggravated dyslipidemia and oxidative stress in aging mice. In brief, our findings suggest that loss of ApoE alters the composition of the gut microbiota, which in turn may affect cognitive function in aging mice through the gut microbiota–brain axis.

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Section: Discussionmentioning

confidence: 99%