Metabolism of Insecticides, DDT Metabolites in Feces and Bile of Rats

Jensen, Joan; Cueto, Cipriano; Dale, William E.; Rothe, Carl F.; Pearce, G. W.; Mattson, A. M.

doi:10.1021/jf60082a002

Cited by 60 publications

(16 citation statements)

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“…The data reported here suggest that a similar effect of SPE can be predicted for certain toxic lipophilic materials such as DDT and chlordecone, which are excreted in the bile either chemically unchanged or as lipophilic metabolites (Jensen et al, 1957;Cohn et al, 1978). If these lipophilic metabolites are resorbable, the egress of a lipophile from tissues can be accelerated by interruption of its enterohepatic circulation (Cohn et al, 1978).…”

Section: Discussionsupporting

confidence: 64%

Effect of a nonabsorbable lipid, sucrose polyester, on the absorption of DDT by the rat

Volpenhein

Webb

Jandacek

1980

Journal of Toxicology and Environmental Health

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Section: Discussionsupporting

confidence: 64%

Effect of a nonabsorbable lipid, sucrose polyester, on the absorption of DDT by the rat

Volpenhein

Webb

Jandacek

1980

Journal of Toxicology and Environmental Health

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“…In addition, there is evidence to suggest that DDT plays an important role in the development of obesity [5,43,44]. DDT and its metabolites are thereafter eliminated mainly via urine and to a lesser extend in feces [45] as well as in breast milk [46].…”

Section: Toxicokinetics Of Main Pops and Their Metabolitesmentioning

confidence: 99%

Adverse effects of weight loss: Are persistent organic pollutants a potential culprit?

Rouhou

Karelis

St-Pierre

et al. 2016

Diabetes & Metabolism

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“…'"Previous workers (17) have shown that DDT metabolite conjugates are formed, although their exact nature is not known. However, they do not appear to be conjugated with glucuronic or sulfuric acids.…”

Section: Imentioning

confidence: 99%

On the Chemistry of the Isomeric Dichlorodiphenylacetaldehydes Related to DDT. Stereoelectronic Effects in the Hydrolysis of their Cyclic Acetals

McKinney¹,

Hawk²,

Boozer³

et al. 1971

Can. J. Chem.

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The chemistry of the isomeric dichlorodiphenylacetaldehydes related to DDT was investigated to aid in delineating their possible role in the metabolism of this pesticide. In the case of the p,p′-isomer, the most important system under consideration, several literature syntheses were shown to be incorrect. The failure of at least one of these methods was attributed to the preferred oxidative involvement of the benzhydryl carbon via rearrangement of a β-hydroxy enol ether which normally led to the isolation of the p,p′-dichlorobenzophenone instead of the desired aldehyde. The o,p′-isomer exhibited chemistry similar to that of the p,p′-isomer although the steric effect of the ortho-substituted chlorine on the benzhydryl proton was notable. The o,o′-isomer was normal in that it did not undergo reactions involving the benzhydryl carbon. Some possible mechanistic and biological implications of the work are discussed.

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Metabolism of Insecticides, DDT Metabolites in Feces and Bile of Rats

Cited by 60 publications

References 1 publication

Effect of a nonabsorbable lipid, sucrose polyester, on the absorption of DDT by the rat

Effect of a nonabsorbable lipid, sucrose polyester, on the absorption of DDT by the rat

Adverse effects of weight loss: Are persistent organic pollutants a potential culprit?

On the Chemistry of the Isomeric Dichlorodiphenylacetaldehydes Related to DDT. Stereoelectronic Effects in the Hydrolysis of their Cyclic Acetals

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