Metabolism of ellagitannins from jabuticaba (Myrciaria jaboticaba) in normoweight, overweight and obese Brazilians: Unexpected laxative effects influence urolithins urinary excretion and metabotype distribution

Inada, Kim Ohanna Pimenta; Tomás-Barberán, Francisco A.; Perrone, Daniel; Monteiro, Mariana

doi:10.1016/j.jff.2019.04.025

Cited by 27 publications

(23 citation statements)

References 42 publications

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“…As far as we know, only Inada et al [18] analysed in vivo the production of urolithins after ingestion of a berry powder in NW and OW subjects, reporting similar results that are in agreement with our findings, without significant differences between the weight condition. However, a tendency was also observed related to the body weight condition.…”

Section: Microbial Phenolic Catabolitessupporting

confidence: 91%

Influence of Raspberry and Its Dietary Fractions on the In vitro Activity of the Colonic Microbiota from Normal and Overweight Subjects

Núñez-Gómez

Periago

Navarro‐González

et al. 2021

Plant Foods Hum Nutr

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Raspberry is a source of dietary fibre and phenolic compounds, which are metabolised by the gut microbiota, resulting in the production of short chain fatty acids (SCFAs) and phenolic catabolites; but the formation of these compounds depends on the microbiota composition. The aim of this study was to investigate whether the raspberry and its fractions (phenolic extract, total and insoluble dietary fibre) affect the microbial activity depending on the body weight condition. For this, in vitro fermentations of raspberry fractions were carried out using faeces from normal-weight (NW) and overweight volunteers (OW) during 48 h, and phenolic catabolites and SCFAs were analysed at 0, 6, 24 and 48 h. The whole raspberry and the phenolic extract produced greater quantities of urolithins and total SCFAs when compared with fibre fractions, reaching the highest amount between 24 and 48 h. The body weight condition was an important factor, since faeces from NW led to greater production of urolithins from non-extractable phenolic compounds bound to fibre fractions, whereas in OW the urolithins production was higher from the fractions with more extractable polyphenols. In summary, the whole raspberry has been shown to have a prebiotic effect, mainly due to its phenolic compounds content rather than its fibre content.

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Section: Microbial Phenolic Catabolitessupporting

confidence: 91%

Influence of Raspberry and Its Dietary Fractions on the In vitro Activity of the Colonic Microbiota from Normal and Overweight Subjects

Núñez-Gómez

Periago

Navarro‐González

et al. 2021

Plant Foods Hum Nutr

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“…As reported for the Europeans, three UMs were also observed in the Brazilians, while the difference in the gut microbiota composition was not explored. 23 The composition of the gut microbiome is affected by several factors, such as eating habits, living environment, health condition, and host genetics. Thus, various races could be characterized by different gut microbiome characteristics.…”

Section: ■ Introductionmentioning

confidence: 99%

Distribution of Urolithins Metabotypes in Healthy Chinese Youth: Difference in Gut Microbiota and Predicted Metabolic Pathways

Xian

Yang

Deng

et al. 2021

J. Agric. Food Chem.

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This is the first study to report the distribution of urolithin metabotypes (UMs) in Asian people, specifically in the Chinese. As was reported for Europeans and Latin Americans, three UMs were observed, UM-A (54.3%), UM-B (31.4%), and UM-0 (14.3%), in 35 healthy Chinese youth. The richness and diversity of gut microbiota were lower in UM-0 than in UM-A and UM-B at the genus level. Gordonibacter in UM-A and UM-B was significantly higher than that in UM-0. The Akkermansia was not found in UM-0. The correlation analysis between the type and content of urolithins and the gut microbiota at the genus level showed that 27 genera were significantly positively correlated with urolithin A and 20 genera were significantly positively associated with isourolithin A and urolithin B. In addition, different KEGG pathways such as TCA cycle, energy metabolism, and some disease were found between the gut microbiome of the three UMs. Further research is needed to explore the mechanisms of metabotypes and the differential health benefits or illness predisposition of the three UMs.

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“…, 2017; Inada et al. , 2019). Therefore, the characteristics of Uro A and Uro B are not related to race and food source, but to obesity and EA.…”

Section: Resultsmentioning

confidence: 99%

“…Two clinical trials involving the intake of pomegranate and Brazilian grapes rich in ellagitannin have shown that although there were differences in living habits between European and Brazilians, their intestinal microflora were very similar in terms of EA metabolism. The content of Uro A in healthy group is higher than that in obese group, while Uro B is higher in obese group (Selma et al, 2017;Inada et al, 2019). Therefore, the characteristics of Uro A and Uro B are not related to race and food source, but to obesity and EA.…”

Section: Effects Of In Vitro Colonic Fermentation On Phenolic Compoundsmentioning

confidence: 88%

Metabolic and microbial modulation of phenolic compounds from raspberry leaf extract under in vitro digestion and fermentation

Yang

Hao

et al. 2021

Int J of Food Sci Tech

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Raspberry leaves, by-products in raspberry production, are also a rich source of bioactive phytochemicals. In this study, the changes of phenolic compounds in raspberries leaf extract (RLE) under in vitro digestion and colonic fermentation were further studied by HPLC-MS analysis and 16S rRNA. The results showed that the phenolic compounds in RLE were relatively stable during in vitro gastric digestion; however, in the subsequent intestinal digestion and colonic fermentation, their content decreased sharply. A large amount of hydroxyphenylpropionic acid, hydroxyphenylacetic acid and urolithins were produced under the action of gut microbiota. Moreover, compared with corresponding control, RLE significantly reduced the ratio of Firmicutes/Bacteroidetes in all volunteers, increased the relative abundances of some beneficial bacteria, Enterococcus, Prevotella, and decreased the relative abundances of potential pathogens, Clostridium and Faecalibacterium. These findings suggest that RLE during in vitro digestion and fermentation has positive effects on gut microbiota and potential value of maintaining intestinal health.

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Metabolism of ellagitannins from jabuticaba (Myrciaria jaboticaba) in normoweight, overweight and obese Brazilians: Unexpected laxative effects influence urolithins urinary excretion and metabotype distribution

Cited by 27 publications

References 42 publications

Influence of Raspberry and Its Dietary Fractions on the In vitro Activity of the Colonic Microbiota from Normal and Overweight Subjects

Influence of Raspberry and Its Dietary Fractions on the In vitro Activity of the Colonic Microbiota from Normal and Overweight Subjects

Distribution of Urolithins Metabotypes in Healthy Chinese Youth: Difference in Gut Microbiota and Predicted Metabolic Pathways

Metabolic and microbial modulation of phenolic compounds from raspberry leaf extract under in vitro digestion and fermentation

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