Metabolism of dextrosulphenidol in several animal species

McChesney, Evan W.; Koss, Raymond F.; Shekosky, James M.; Deitz, William H.

doi:10.1002/jps.3030491207

Cited by 25 publications

(6 citation statements)

References 3 publications

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“…1 and 2). The elevated and rapid transfer of TAP from the intravas cular to the extravascular compartment is, on the other hand, known from preceding studies in which it results that the relation between the an tibiotic concentration in the tissues (lung, spleen, liver, kidneys) and that in the plasma is greater than unity [19].…”

Section: Discussionmentioning

confidence: 98%

“…The antibiotic levels in the plasma, in the sputum and in the lung tissue were de termined with the chemical method of McChesney et al [18] for free TAP; this method allows evaluation of the antibiotic only in its free and unmodified form and the results are superimposable with those obtained by microbiological assay [19]. Before proceeding with the determination of the antibiotic, the bronchial secretions were homogenized and the lung tissue repeatedly washed in physiologic solution un til no trace of blood remained.…”

Section: Purulencementioning

confidence: 99%

“…The pharmacological data indicate that, once absorbed, the antibiotic is practically not combined with the plasma proteins [10] and not in activated by metabolic processes [9,19].…”

mentioning

confidence: 99%

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Diffusion of Thiamphenicol in the Bronchial Secretions and in the Lung Tissue

Cambieri¹,

Gambini²,

Lodola³

1970

Chemotherapy

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The diffusion of thiamphenicol (TAP) from the blood to the bronchial secretions of subjects with chronic bronchitis and to the lung tissue in patients with tuberculosis or neoplasm was studied. The penetration of the antibiotic into the bronchial secretions was not correlated with the quantity of sputum. Superimposable concentrations were found in mucopurulent and mucoid sputum: the respective means were 4.72 and 5.02 μg/g. The TAP concentrations in the lung tissue were proportional to the dose of antibiotic administered and of the same order as the plasma levels. The influence of the antibiotic levels in the bronchial secretions in the course of chronic bronchitis is discussed.

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Section: Discussionmentioning

confidence: 98%

Section: Purulencementioning

confidence: 99%

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Diffusion of Thiamphenicol in the Bronchial Secretions and in the Lung Tissue

Cambieri¹,

Gambini²,

Lodola³

1970

Chemotherapy

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“…In the body it is not appreciably protein bound and does not undergo significant biotransformation (5). With normal renal function most of an administered dose is excreted unchanged in the urine (3,7). Also, thus far irreversible aplastic anemia has not been reported with the use of this drug (20).…”

mentioning

confidence: 99%

Peritoneal Transfer of Thiamphenicol During Peritoneal Dialysis

Koornhof²,

Kilroe-Smith³

et al. 1976

Antimicrob Agents Chemother

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The pharmacokinetics of thiamphenicol (TAP) was studied in 17 functionally anephric patients during peritoneal dialysis. Eleven patients were given single intramuscular injections of TAP in doses of 10 to 20 mg/kg of body weight. After this, serial blood samples and outflow dialysate collections were assayed for TAP by gas chromatography. The mean overall elimination rate constant was 0.036 ± 0.007/h, the serum half time was 8.4 h, and the apparent volume of distribution was 71.0% (±14.39%) of the body weight. These parameters were not significantly different from those determined in anephric patients not on dialysis. The mean recovery of the administered TAP doses in the pooled outflow dialysate was 7.7% (±2.76%) over 22 h. In six other patients TAP was added to the inflow dialysate in concentrations of 10 to 20 mg/liter for 22 h. Throughout the dialysis periods, serum TAP levels did not rise above 4 gg/ml in transfer of TAP.

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“…Following oral and parenteral administration, TAP is readily detectable free in the blood and body fluids being al most completely excreted in bile and urine as a chemically unchanged and biologically active substance [3,10].…”

Section: Introductionmentioning

confidence: 99%

Effects of Chloramphenicol and Thiamphenicol on the Outcome of <i>Chlamydia psittac</i><i>i</i> Infection in Chick Embryo

et al. 1982

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The effects of chloramphenicol (CAP) and thiamphenicol (TAP) on the outcome of Chlamydiapsittaci infection in chick embryos were compared. CAP administered along with Chlamydia reduced embryo mortality rates but showed no appreciable effects when its injection was delayed. On the contrary, TAP caused a high rate of embryo survival in both experimental situations. Statistical analysis of the results showed that differences in the survival rates following CAP and TAP administration are significant. Metabolic pathways in chick embryos of the antibiotics assayed differed remarkably in that CAP undergoes a quicker inactivation, which could even justify the better activity showed by TAP.

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Metabolism of dextrosulphenidol in several animal species

Cited by 25 publications

References 3 publications

Diffusion of Thiamphenicol in the Bronchial Secretions and in the Lung Tissue

Diffusion of Thiamphenicol in the Bronchial Secretions and in the Lung Tissue

Peritoneal Transfer of Thiamphenicol During Peritoneal Dialysis

Effects of Chloramphenicol and Thiamphenicol on the Outcome of <i>Chlamydia psittac</i><i>i</i> Infection in Chick Embryo

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