1959
DOI: 10.1016/s0021-9258(18)70246-9
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Metabolism of Chylomicron Proteins in the Dog

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Cited by 121 publications
(3 citation statements)
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“…The small amounts of aspartic acid and glutamic acid have been previously considered to be derived from the protein of overlapping chylomicrons and S; 0-10 lipoproteins, respectively. The reports by Rodbell (1958) and Rodbell and Fredrickson (1959) that N-terminal glutamic acid was not present in chylomicrons or lipoproteins of Sf >100, and by Grundy et al (1961) that only the high-density fraction of Sr 20-400 lipoproteins from nonlipemic plasma contained an ether-extracted residue similar to that found in 5/ 0-20 lipoproteins, provide a basis for this proposal. The results of the present study indicate that this hypothesis must be modified to account for a different protein distribution in Sf 10-400 lipoproteins from lipemic plasma.…”
Section: Discussionmentioning
confidence: 88%
“…The small amounts of aspartic acid and glutamic acid have been previously considered to be derived from the protein of overlapping chylomicrons and S; 0-10 lipoproteins, respectively. The reports by Rodbell (1958) and Rodbell and Fredrickson (1959) that N-terminal glutamic acid was not present in chylomicrons or lipoproteins of Sf >100, and by Grundy et al (1961) that only the high-density fraction of Sr 20-400 lipoproteins from nonlipemic plasma contained an ether-extracted residue similar to that found in 5/ 0-20 lipoproteins, provide a basis for this proposal. The results of the present study indicate that this hypothesis must be modified to account for a different protein distribution in Sf 10-400 lipoproteins from lipemic plasma.…”
Section: Discussionmentioning
confidence: 88%
“…Paper electrophoresis and N-terminal studies led to the conclusion that three different proteins constitute the protein moiety from chylomicrons (Rodbell and Fredrickson, 1959). One of these proteins was found to be identical with apo-HDL:1 another, apo-LP-B, was identified in chylomicrons using immunochemical methods (Lees, 1967).…”
mentioning
confidence: 99%
“…Peptide Maps. Tryptic digests of the subunits were prepared according to Rodbell and Fredrickson (1959), except that the reaction was carried out for 6 hr at 25°. The resulting peptides were desalted, then separated in two dimensions on paper, according to Helinski and Yanofsky (1962).…”
Section: Methodsmentioning
confidence: 99%