Metabolism of anethole. II. Influence of dose size on the route of metabolism of trans-anethole in the rat and mouse

Structure-genotoxicity relationships of allylbenzenes and propenylbenzenes: A quantum chemical study

“…It should be noted that the identical geometry and heat of formation (AHf) of the radical species of estragóle (1) and trans-anethole (9), and of safrole (3) and isosafrole (10) (Table 1), result from the delocalization of the unpaired electron in this type of radicals (Figure 2). Although some propenyl metabolites were detected when allylbenzene, safrole, or eugenol was given to rats (17,20, 21) , double bond migration was either nonexistent or negligible in the metabolites of propenylbenzenes (18)(19)22) . Chem.…”

Structure-genotoxicity relationships of allylbenzenes and propenylbenzenes: A quantum chemical study

“…It should be noted that the identical geometry and heat of formation (AHf) of the radical species of estragóle (1) and trans-anethole (9), and of safrole (3) and isosafrole (10) (Table 1), result from the delocalization of the unpaired electron in this type of radicals (Figure 2). Although some propenyl metabolites were detected when allylbenzene, safrole, or eugenol was given to rats (17,20, 21) , double bond migration was either nonexistent or negligible in the metabolites of propenylbenzenes (18)(19)22) . Chem.…”

Bioavailability and Pharmacokinetics of Natural Volatile Terpenes in Animals and Humans

“…A dose-dependent variation in urinary metabolites was evident for t-anethole in rodents as well as 14 C-eugenol in rats (31). For t-anethole the formation of phase-I metabolites was dose-dependent (28), whereas 14 C-eugenol showed dose-dependent variations of conjugates.…”

The Safety of Flavorings

“…Such work has resulted in publications on cinnamyl anthranilate (Anthony et al 1983; as well as trans-anethole Sangster et al 1984b;Sangster et al 1984a) p-propylanisole , eugenol Sutton et al 1985) and benzyl acetate (Caldwell and Chidgey 1985). Work continues on the metabolism of substituted propyl benzene substances, cinnamyl compounds and benzyl acetate.…”

Structure-genotoxicity relationships of allylbenzenes and propenylbenzenes: A quantum chemical study

“…It should be noted that the identical geometry and heat of formation (AHf) of the radical species of estragóle (1) and trans-anethole (9), and of safrole (3) and isosafrole (10) (Table 1), result from the delocalization of the unpaired electron in this type of radicals (Figure 2). Although some propenyl metabolites were detected when allylbenzene, safrole, or eugenol was given to rats (17,20, 21) , double bond migration was either nonexistent or negligible in the metabolites of propenylbenzenes (18)(19)22) . Chem.…”

Bioavailability and Pharmacokinetics of Natural Volatile Terpenes in Animals and Humans

“…A dose-dependent variation in urinary metabolites was evident for t-anethole in rodents as well as 14 C-eugenol in rats (31). For t-anethole the formation of phase-I metabolites was dose-dependent (28), whereas 14 C-eugenol showed dose-dependent variations of conjugates.…”

The Safety of Flavorings

“…Such work has resulted in publications on cinnamyl anthranilate (Anthony et al 1983; as well as trans-anethole Sangster et al 1984b;Sangster et al 1984a) p-propylanisole , eugenol Sutton et al 1985) and benzyl acetate (Caldwell and Chidgey 1985). Work continues on the metabolism of substituted propyl benzene substances, cinnamyl compounds and benzyl acetate.…”

Structure-genotoxicity relationships of allylbenzenes and propenylbenzenes: A quantum chemical study

“…It should be noted that the identical geometry and heat of formation (AHf) of the radical species of estragóle (1) and trans-anethole (9), and of safrole (3) and isosafrole (10) (Table 1), result from the delocalization of the unpaired electron in this type of radicals (Figure 2). Although some propenyl metabolites were detected when allylbenzene, safrole, or eugenol was given to rats (17,20, 21) , double bond migration was either nonexistent or negligible in the metabolites of propenylbenzenes (18)(19)22) . Chem.…”

Bioavailability and Pharmacokinetics of Natural Volatile Terpenes in Animals and Humans

“…A dose-dependent variation in urinary metabolites was evident for t-anethole in rodents as well as 14 C-eugenol in rats (31). For t-anethole the formation of phase-I metabolites was dose-dependent (28), whereas 14 C-eugenol showed dose-dependent variations of conjugates.…”

The Safety of Flavorings

“…Such work has resulted in publications on cinnamyl anthranilate (Anthony et al 1983; as well as trans-anethole Sangster et al 1984b;Sangster et al 1984a) p-propylanisole , eugenol Sutton et al 1985) and benzyl acetate (Caldwell and Chidgey 1985). Work continues on the metabolism of substituted propyl benzene substances, cinnamyl compounds and benzyl acetate.…”