Metabolism of [14C]dieldrin in bluegill fish

Sudershan, P.; Khan, Mohammad Zafar

doi:10.1016/0048-3575(81)90085-7

Cited by 16 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other researchers have reported minimal dieldrin metabolism by bluegills [15] and goldfish [16]. Ration and treatment altered the percentages found in each compartment, but recoveries averaged 15% in water, 17% in whole body homogenates, 20% in viscera and 5% in feces.…”

Section: Disposition Studiesmentioning

confidence: 79%

Ration and toxicant preexposure influence dieldrin accumulation by rainbow trout (Salmo gairdneri)

Shubat

Curtis

1986

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Whole body accumulation and tissue distribution of dieldrin in rainbow trout were studied through oral‐dose disposition tests and subchronic exposures via water (0.04 and 0.08 μg dieldrin/L) and/or diet (0.087 μg dieldrin/g fish/d). Growth and no‐growth (maintenance) rations of 4 and 2% body weight per day were employed. In subchronic tests, apparent steady‐state residue concentrations depended on ration and exposure concentration after 8 weeks of exposure. At 16 weeks, mean whole fish residue concentrations ranged from 120 to 1,400 ng dieldrin/g fish. Combination food and water exposures at a growth ration produced the highest accumulation values (1,300–1,400 ng dieldrin/g fish). Maintenance rations apparently limited accumulation to a maximum of 360 ng dieldrin/g fish. Whole body dieldrin concentration, calculated on the basis of total lipids, greatly reduced the differences in residue levels due to ration. Tissue distribution of a single oral dose of [14C]dieldrin was determined in naive (no pretreatment) fish and those preexposed via the diet for 2, 4 or 6 weeks. Tissue concentrations of the tracer dose were determined 48 h following administration. Retention of the [14C]dieldrin was similar in most tissues of naive, 2‐ or 6‐week dieldrin‐pretreated fish with a slight downward trend with duration of pretreatment. Retention of 14C in the bile of fish receiving maintenance and growth treatments increased two‐ and five‐fold, respectively, in 6‐week pretreated as compared with naive fish. After 4 weeks of pretreatment, 14C concentrations peaked in all tissues except the bile, gut, and gut contents.

show abstract

Section: Disposition Studiesmentioning

confidence: 79%

Ration and toxicant preexposure influence dieldrin accumulation by rainbow trout (Salmo gairdneri)

Shubat

Curtis

1986

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

show abstract

“…For example, environmental and metabolic transformation of dieldrin has been reported to form a variety of possible products, including photodieldren and its carbonylic metabolite keto-photodieldrin . Bridged keto-photodieldrin is mainly found in the urine and kidneys of male rats after being dosed with high levels of dieldrin. , It was also found as a major metabolite in bluegill fish (Lepomis macrochirus) following dieldrin exposure . Given the partial similarity between Dec603 and dieldrin in their molecular structures, we hypothesize that Dec603 follows metabolic pathways similar to those reported for dieldrin for the formation of U2.…”

Section: Results and Discussionmentioning

confidence: 99%

“…36,37 It was also found as a major metabolite in bluegill fish (Lepomis macrochirus) following dieldrin exposure. 38 Given the partial similarity between Dec603 and dieldrin in their molecular structures, we hypothesize that Dec603 follows metabolic pathways similar to those reported for dieldrin for the formation of U2. The potential metabolic pathways are interpreted below by using a possible U2 structure (see Figure 3) as an example.…”

Section: Environmental Science and Technologymentioning

confidence: 99%

Novel Dechlorane Analogues and Possible Sources in Peregrine Falcon Eggs and Shark Livers from the Western North Atlantic Regions

Liu

Zhang

et al. 2019

Environ. Sci. Technol.

View full text Add to dashboard Cite

During the investigation of dechlorane-related chemicals in North American wildlife, two unknown polychlorinated compounds (referred to as U1 and U2) were discovered. After extensive sample cleanup, structural information on U1 and U2 was characterized by gas chromatography (GC) coupled with single quadrupole mass spectrometer (MS) or GC-quadrupole time-of-flight (QToF) MS. Mass spectral evidence suggests that both U1 and U2 are structurally related to Dechlorane 603 (Dec603; C17H8Cl12), an analogue of the chlorinated flame retardant Dechlorane Plus. From the results we suspect U1 (C17H9Cl11) to be a monohydro analogue of Dec603 (i.e., one chlorine atom in Dec603 is replaced by a hydrogen atom). U1 may be formed via the degradation of Dec603’s stereoisomers or present as an impurity in commercial Dec603 products. Mass spectral characterization of U2 (C17H7OCl11) suggests it is a carbonylic derivative of Dec603, likely formed via metabolic transformation of Dec603 or its photoisomer. Semiquantitative measurement revealed that U1 and U2 were present at estimated median concentrations of 49 ng/g lipid weight (lw) and 59 ng/g lw in peregrine falcon (Falco peregrinus) eggs, from the mid-Atlantic region of the United States, and 4.6 and 3.0 ng/g lw in shortfin mako shark (Isurus oxyrinchus) livers from the western North Atlantic Ocean, respectively. Our results demonstrate the occurrence of these two novel Dec603-related chemicals in both terrestrial and aquatic ecosystems.

show abstract

“…No attempt was made to distinguish metabolites from parent compound. Other researchers have reported minimal dieldrin metabolism by bluegills [15] and goldfish [16]. Fish fed 2 or 5% rations grew over the longer pretreatment periods, but fish pretreated for 6 weeks on the low ration had less visceral fat (0.013 g) than did fish fed the high ration (0.13 g fat).…”

Section: Disposition Studiesmentioning

confidence: 84%

Ration and Toxicant Preexposure Influence Dieldrin Accumulation by Rainbow Trout (Salmo Gairdneri)

Shubat¹,

Curtis²

1986

Environ Toxicol Chem

View full text Add to dashboard Cite

Whole body accumulation and tissue distribution of dieldrin in rainbow trout were studied through oral-dose disposition tests and subchronic exposures via water (0.04 and 0.08 wg dieldrin/L) and/or diet (0.087 wg dieldrinig fishid). Growth and no-growth (maintenance) rations of 4 and 2% body weight per day were employed. In subchronic tests, apparent steady-state residue concentrations depended on ration and exposure concentration after 8 weeks of exposure. At 16 weeks, mean whole fish residue concentrations ranged from 120 to 1,400 ng dieldrinig fish. Combination food and water exposures at a growth ration produced the highest accumulation values (1,300-1,400 ng dieldrin/g fish). Maintenance rations apparently limited accumulation to a maximum of 360 ng dieldrin/g fish. Whole body dieldrin concentration, calculated on the basis of total lipids, greatly reduced the differences in residue levels due to ration.Tissue distribution of a single oral dose of [14C]dieldrin was determined in naive (no pretreatment) fish and those preexposed via the diet for 2, 4 or 6 weeks. Tissue concentrations of the tracer dose were determined 48 h following administration. Retention of the ['4C)dieldrin was similar in most tissues of naive, 2-or 6-week dieldrin-pretreated fish with a slight downward trend with duration of pretreatment. Retention of I4C in the bile of fish receiving maintenance and growth treatments increased two-and five-fold, respectively, in 6-week pretreated as compared with naive fish. After 4 weeks of pretreatment, I4C concentrations peaked in all tissues except the bile, gut, and gut contents.

show abstract

Metabolism of [14C]dieldrin in bluegill fish

Cited by 16 publications

References 17 publications

Ration and toxicant preexposure influence dieldrin accumulation by rainbow trout (Salmo gairdneri)

Ration and toxicant preexposure influence dieldrin accumulation by rainbow trout (Salmo gairdneri)

Novel Dechlorane Analogues and Possible Sources in Peregrine Falcon Eggs and Shark Livers from the Western North Atlantic Regions

Ration and Toxicant Preexposure Influence Dieldrin Accumulation by Rainbow Trout (Salmo Gairdneri)

Contact Info

Product

Resources

About