Metabolism, obesity and the metabolic syndrome

Persson, Pontus B.; Persson, Anja Bondke

doi:10.1111/apha.13096

Cited by 11 publications

(8 citation statements)

References 28 publications

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“…Thus, adipose tissue might play a major role in metabolic alterations of critical illness. For instance, increased proinflammatory cytokines are expressed in hypertrophied adipocytes and adipose tissue resident immune cells [37].…”

Section: Discussionmentioning

confidence: 99%

Decreased CTRP3 Plasma Concentrations Are Associated with Sepsis and Predict Mortality in Critically Ill Patients

Yagmur¹,

Otto

Koek

et al. 2019

Diagnostics

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C1q/ tumor necrosis factor (TNF)-like protein 3 (CTRP3) represents a novel member of the adipokine family that exerts favorable metabolic actions in humans. However, the role of CTRP3 in critical illness and sepsis is currently unknown. Upon admission to the medical intensive care unit (ICU), we investigated CTRP3 plasma concentrations in 218 critically ill patients (145 with sepsis, 73 without sepsis). Results were compared with 66 healthy controls. CTRP3 plasma levels were significantly decreased in critically ill patients, when compared to healthy controls. In particular, low CTRP3 levels were highly associated with the presence of sepsis. CTRP3 levels were neither associated with obesity nor diabetes. In critically ill patients, CTRP3 plasma concentrations were inversely correlated with inflammatory cytokines and classical sepsis markers. Among a wide group of adipokines, CTRP3 only correlated with circulating resistin. Low CTRP3 plasma levels were associated with the overall mortality, and CTRP3 levels below 620.6 ng/mL indicated a particularly increased mortality risk in ICU patients. Our study demonstrates for the first time the role of circulating CTRP3 as a biomarker in critically ill patients that might facilitate diagnosis of sepsis as well as prognosis prediction. The association between low CTRP3 and increased inflammation warrants further pathophysiological investigations.

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Section: Discussionmentioning

confidence: 99%

Decreased CTRP3 Plasma Concentrations Are Associated with Sepsis and Predict Mortality in Critically Ill Patients

Yagmur¹,

Otto

Koek

et al. 2019

Diagnostics

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“…A number of articles addressing basic mechanisms related to obesity have recently appeared in Acta physiologica. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] One area of clinical relevance for obese patients is the immune system. Duan et al 20 recapitulate the connections between a high-fat diet and diseases.…”

mentioning

confidence: 99%

“…A precise understanding of these effects is necessary to comprehend specific needs of obese patients. A number of articles addressing basic mechanisms related to obesity have recently appeared in Acta physiologica …”

mentioning

confidence: 99%

Adipose tissue—more than just fat

Groeneveld

2020

Acta Physiologica

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“…Obesity is not only excessive fat accumulation around the body, but a condition characterized by metabolic changes with adverse effects on health . Those metabolic adaptions need to be further elucidated to understand the crosstalk between adipose tissue and other organ systems like skeletal muscle or liver to find potential targets for pharmacological interventions in obesity.…”

mentioning

confidence: 99%