Metabolism in Retinopathy of Prematurity

Tomita, Yohei; Usui‐Ouchi, Ayumi; Nilsson, Anders; Yang, Jay; Ko, Minji; Hellström, Ann; Fu, Zhongjie

doi:10.3390/life11111119

Cited by 19 publications

(15 citation statements)

References 204 publications

(261 reference statements)

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“…Both of the mechanisms can promote the release and formation of neoangiogenesis mediators induced by hypoxia. Long term fetal hypoxia and/or ischemia may play a role in the pathogenesis of ROP [1,29] . In addition, premature vaginal delivery can often cause vaginal infection of newborn, which also increases the occurrence of ROP and retinal neovascularization [30][31] .…”

Section: Resultsmentioning

confidence: 99%

Clinical feature and predictive factor analysis for spontaneous regression of retinopathy of prematurity in a Chinese population

Li¹,

Cai²,

Yang³

2022

Int J Ophthalmol

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AIM: To investigate the ratio of spontaneous regression of retinopathy of prematurity (ROP) and to explore the possible relevant predictive factors. METHODS: A retrospective review of 405 infants who were diagnosed with ROP and mother during pregnancy were collected. Stage, zone, and duration of ROP were recorded. Statistical analysis was performed on 51 possible predictive factors. RESULTS: Totally 356 infants showed spontaneous regression. The incidence was 100%, 95.3%, and 22.7% in stage 1, 2, and 3, respectively. The 13.4% of the ROP with plus disease eventually resolved spontaneously. All affected eyes of aggressive posterior retinopathy of prematurity (AP-ROP) failed to spontaneously regress. The mean duration of ROP was 7.2wk in patients with spontaneous resolution of ROP. Days of mechanical ventilation (OR=0.981, 95%CI, 0.965-0.997, P=0.021), retinal hemorrhage (OR=0.173, 95%CI, 0.064-0.470, P=0.001), delivery pattern (OR=2.750, 95%CI, 1.132-6.681, P=0.025), maternal anemia in pregnancy (OR=0.142, 95%CI, 0.036-0.563, P=0.005), the stages (at initial diagnosis OR=0.183, 95%CI, 0.041-0.816, P=0.026; at final diagnosis OR=0.031, 95%CI, 0.006-0.167, P<0.001), and with plus disease or not (OR=0.005, 95%CI, 0.001-0.031, P<0.001) were independent predictive factors of the spontaneous regression of ROP. CONCLUSION: Most mild ROP can spontaneously resolve. Active treatment is still recommended for stage 3 ROP, zone I ROP, AP-ROP, and ROP with plus disease. Prolonged mechanical ventilation and concurrent retinal hemorrhage reduce the likelihood of spontaneous ROP resolution. The pattern of delivery and the mother’s anemia during pregnancy can also affect the prognosis of ROP.

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Section: Resultsmentioning

confidence: 99%

Clinical feature and predictive factor analysis for spontaneous regression of retinopathy of prematurity in a Chinese population

Li¹,

Cai²,

Yang³

2022

Int J Ophthalmol

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“…Delayed physiologic retinal vascular development causes hypoxia with consequent ischemia that leads to angiogenic signaling with increased expression of VEGF. Hence, vasoproliferation with disordered proliferation into the vitreous occurs (26)(27)(28).…”

Section: Retinopathy Of Prematuritymentioning

confidence: 99%

Methods to measure blood flow and vascular reactivity in the retina

Böhm

Pfeiffer²,

Wagner³

et al. 2023

Front. Med.

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Disturbances of retinal perfusion are involved in the onset and maintenance of several ocular diseases, including diabetic retinopathy, glaucoma, and retinal vascular occlusion. Hence, knowledge on ocular vascular anatomy and function is highly relevant for basic research studies and for clinical judgment and treatment. The retinal vasculature is composed of the superficial, intermediate, and deep vascular layer. Detection of changes in blood flow and vascular diameter especially in smaller vessels is essential to understand and to analyze vascular diseases. Several methods to evaluate blood flow regulation in the retina have been described so far, but no gold standard has been established. For highly reliable assessment of retinal blood flow, exact determination of vessel diameter is necessary. Several measurement methods have already been reported in humans. But for further analysis of retinal vascular diseases, studies in laboratory animals, including genetically modified mice, are important. As for mice, the small vessel size is challenging requiring devices with high optic resolution. In this review, we recapitulate different methods for retinal blood flow and vessel diameter measurement. Moreover, studies in humans and in experimental animals are described.

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“…ROP is related to hypoxia and nutrient deprivation in the maturation of retinal blood vessels, and regulation of retinal metabolism can prevent pathological angiogenesis. Recent research on the metabolic changes of ROP shows that metabolites can serve as biomarkers ( 35 ). Metabolomics affects cell physiology by regulating the genome, epigenome, transcriptome, and proteome ( 36 ).…”

Section: Candidates Of Novel Potential Biomarkersmentioning

confidence: 99%

Novel Potential Biomarkers for Retinopathy of Prematurity

Tan

Wang

et al. 2022

Front. Med.

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Retinopathy of prematurity (ROP) is the main risk factor for vision-threatening disease in premature infants with low birth weight. An accumulating number of independent studies have focused on ROP pathogenesis and have demonstrated that laser photocoagulation therapy and/or anti-VEGF treatment are effective. However, early diagnosis of ROP is still critical. At present, the main method of ROP screening is based on binocular indirect ophthalmoscopy. However, the judgment of whether ROP occurs and whether treatment is necessary depends largely on ophthalmologists with a great deal of experience. Therefore, it is essential to develop a simple, accurate and effective diagnostic method. This review describes recent findings on novel biomarkers for the prediction, diagnosis and prognosis of ROP patients. The novel biomarkers were separated into the following categories: metabolites, cytokines and growth factors, non-coding RNAs, iconography, gut microbiota, oxidative stress biomarkers, and others. Biomarkers with high sensitivity and specificity are urgently needed for the clinical applications of ROP. In addition, using non-invasive or minimally invasive methods to obtain samples is also important. Our review provides an overview of potential biomarkers of ROP.

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Metabolism in Retinopathy of Prematurity

Cited by 19 publications

References 204 publications

Clinical feature and predictive factor analysis for spontaneous regression of retinopathy of prematurity in a Chinese population

Clinical feature and predictive factor analysis for spontaneous regression of retinopathy of prematurity in a Chinese population

Methods to measure blood flow and vascular reactivity in the retina

Novel Potential Biomarkers for Retinopathy of Prematurity

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