Metabolism gene signatures and surgical site infections in abdominal surgery

Kong, Bo; Bruns, Philipp; Raulefs, Susanne; Rieder, Simon; Paul, L; Costa, Olivia Prazeresda; Buch, Thorsten; Theis, Fabian J.; Michalski, Christoph; Kleeff, Jörg

doi:10.1016/j.ijsu.2015.01.009

Cited by 4 publications

(1 citation statement)

References 43 publications

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“…We noted frequency of 1.66% SSI in Povidone-Iodine cases that is in agreement with previous studies. [19][20][21] We conclude that the Povidone-Iodine prophylaxis is effective in preventing post appendectomy surgical site infection. Small sample size is one of the limitations of present study.…”

Section: Controlmentioning

confidence: 99%

Surgical Site Infection;

Memon

Shaikh

Memon

et al. 2019

TPMJ

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Objectives: Efficacy of postoperative Povidone-Iodine prophylaxis and surgical site infection in appendectomy surgery. Study Design: Randomized clinical trial. Place and Duration: Department of Surgery, Liaquat University Hospital Jamshoro/Hyderabad from March 2016 to November 2017. Subjects and Methods: Diagnosed cases of acute appendicitis with classical clinical presentation were included in the study protocol. 60 patients were those, who were applied 1% povidone-iodine solution (cases) to wound post operatively versus 60 patients (control) were those in whom wound not irrigated with Povidone- Iodine. Ethical approval and consent were taken. Data was noted in a proforma and analyzed on SPSS 22.0 (P≤0.05). Results: Age (mean ± SD) in control and cases was observed as 25.5 ± 8.5 and 24.5 ± 9.5 years respectively (P=0.76). Male and female were noted as 43 (%) and 17 (%) & 45 (%) and 15 (%) in control and cases respectively (P >0.05). Wound healing score by Southampton classification of wound healing shows lesser frequency of surgical site infection in cases compared to controls (P <0.05). Grade 4 pus discharging wound infection was noted in 2 (3.33%) control versus 3 (5.0%) in cases (P=0.021). Conclusion: It is concluded that the 1% Povidone- Iodine solution is effective in preventing the post appendectomy surgical site infection.

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Section: Controlmentioning

confidence: 99%

Surgical Site Infection;

Memon

Shaikh

Memon

et al. 2019

TPMJ

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Outcome after pharyngeal reconstruction using pectoralis major and radial forearm flap after resection of pharyngeal and laryngeal squamous cell carcinomas

Knopf

Mansour

Hofauer

et al. 2015

Eur Arch Otorhinolaryngol

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The objective of this study is to assess the outcome after pharyngeal reconstruction using pectoralis major and radial forearm flaps in pharyngeal and laryngeal carcinomas. 90 patients who underwent flap surgery due to oro/-hypopharyngeal and laryngeal carcinomas were compared with 404 patients without pharyngeal reconstruction. Differences between the groups were analyzed using the Chi-square, Fisher exact, and the unpaired student's t test. Survival rates were calculated by Kaplan-Meier. Overall survival in oropharyngeal and hypopharyngeal/laryngeal cancer showed comparable results in patients with or without pharyngeal reconstruction (5-year: 53.4 vs. 64.2 %, p = 0.23; 5-year: 51.8 vs. 62.4 %, p = 0.94), while the survival time after flap surgery was significantly decreased (5-year: 44.8 vs. 62.4 %, p < 0.02; 5-year: 30.3 vs. 64.2 %, p = 0.07). Subgroup analysis attributed the worse survival after flap surgery to patients who underwent flap surgery due to functional deficits or recurrent disease (p = 0.002). In these patients, the median survival after flap surgery was 26 (hypopharyngeal/laryngeal cancer) or 13 months (oropharyngeal cancer) and associated with a significant increase in severe complications and hospitalization time (p < 0.0001). The hospitalization time correlated with the history of prior radiotherapy and the extent of surgery (r = 0.26; r = 0.3; p < 0.0001). Flap surgery in primary oropharyngeal and hypopharyngeal/laryngeal cancer showed an unaltered overall survival when compared with patients without reconstruction. Patients with recurrent disease or functional deficits demonstrated a significant decrease in survival combined with an increase of severe complications.

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