Metabolism and successful aging: Polymorphic variation of syndecan-4 (SDC4) gene associate with longevity and lipid profile in healthy elderly Italian subjects

Rose, Giuseppina; Crocco, Paolina; Rango, Francesco De; Corsonello, Andrea; Lattanzio, Fabrizia; Luca, María De; Passarino, Giuseppe

doi:10.1016/j.mad.2015.08.003

Cited by 18 publications

(16 citation statements)

References 47 publications

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“…In accordance with previous works, changes in total cholesterol and LDL-cholesterol were found in the elderly compared with adults and centenarians [27], [28], [29]. Focusing on ether lipid species, our results demonstrate that total ether lipids are significant lower in centenarians.…”

Section: Discussionsupporting

confidence: 93%

Exceptional human longevity is associated with a specific plasma phenotype of ether lipids

et al. 2019

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A lipid profile resistant to oxidative damage is an inherent trait associated with animal lifespan. However, there is a lack of lipidomic studies on human longevity. Here we use mass spectrometry based technologies to detect and quantify 137 ether lipids to define a phenotype of healthy humans with exceptional lifespan. Ether lipids were chosen because of their antioxidant properties and ability to modulate oxidative stress. Our results demonstrate that a specific ether lipid signature can be obtained to define the centenarian state. This profile comprises higher level of alkyl forms derived from phosphatidylcholine with shorter number of carbon atoms and double bonds; and decreased content in alkenyl forms from phosphatidylethanolamine with longer chain length and higher double bonds. This compositional pattern suggests that ether lipids from centenarians are more resistant to lipid peroxidation, and that ether lipid signature expresses an optimized feature associated with exceptional human longevity. These results are in keeping with the free radical theory of aging.

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Section: Discussionsupporting

confidence: 93%

Exceptional human longevity is associated with a specific plasma phenotype of ether lipids

et al. 2019

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“…However, the overall outcome seemed to reduce lipid levels and thus accounted for the favorable lipid profile in centenarians. Of course, there exist many other influential factors that may explain the favorable lipid level in CEN, such as hormone regulation 22 23 and gene polymorphic variants 20 24 25 26 .…”

Section: Discussionmentioning

confidence: 99%

Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families

Xiao

et al. 2016

Sci Rep

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Centenarians are a good healthy aging model. Interestingly, centenarians’ offspring are prone to achieve longevity. Here we recruited 60 longevity families and investigated the blood biochemical indexes of family members to seek candidate factors associated with familial longevity. First, associations of blood indexes with age were tested. Second, associations of blood parameters in centenarians (CEN) with their first generation of offspring (F1) and F1 spouses (F1SP) were analyzed. Third, genes involved in regulating target factors were investigated. We found that total cholesterol (TC) and triglyceride (TG) increased with age (20–80 years), but decreased in CEN. Similarly, blood urea nitrogen (BUN) and blood creatinine (BCr) increased with age (20–80 years), but were maintained on a plateau in CEN. Importantly, we first revealed dual changes in blood pressure, i.e., decreased diastolic blood pressure but increased systolic blood pressure in CEN, which associated with altered CST3 expression. Genetic analysis revealed a significant association of blood uric acid (BUA) and BCr in CEN with F1 but not with F1SP, suggesting they may be heritable traits. Taken together, our results suggest serum lipids, kidney function and especially diastolic pressure rather than systolic pressure were improved in CEN or their offspring, suggesting these factors may play an important role in familial longevity.

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“…The same association is also observed for high triglyceride level and for low levels of LDL cholesterol. On the other hand, SNP rs2251252 seems to be associated with longevity and with high levels of LDL (161).…”

Section: Genetic and Epigenetic Factors As Major Determinants Of Immumentioning

confidence: 99%

Inflammaging in Endemic Areas for Infectious Diseases

et al. 2020

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Immunosenescence is marked by a systemic process named inflammaging along with a series of defects in the immunological activity that results in poor responses to infectious agents and to vaccination. Inflammaging, a state of low-grade chronic inflammation, usually leads to chronic inflammatory diseases and frailty in the elderly. However, some elderly escape from frailty and reach advanced age free of the consequences of inflammaging. This process has been called immunological remodeling, and it is the hallmark of healthy aging as described in the studies of centenarians in Italy. The biological markers of healthy aging are still a matter of debate, and the studies on the topic have focused on inflammatory versus remodeling processes and molecules. The sub-clinical inflammatory status associated with aging might be a deleterious event for populations living in countries where chronic infectious diseases are not prevalent. Nevertheless, in other parts of the world where they are, two possibilities may occur. Inflammatory responses may have a protective effect against these infectious agents. At the same time, the long-term consequences of protective immune responses during chronic infections may result in accelerated immunosenescence in these individuals. Therefore, the biological markers of healthy aging can vary according to environmental, cultural, and geographical settings that reflect worldwide, and in a non-biased, non-westernized perspective, the changes that we experience regarding our contacts with microorganisms and the outcomes of such contacts.

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Metabolism and successful aging: Polymorphic variation of syndecan-4 (SDC4) gene associate with longevity and lipid profile in healthy elderly Italian subjects

Cited by 18 publications

References 47 publications

Exceptional human longevity is associated with a specific plasma phenotype of ether lipids

Exceptional human longevity is associated with a specific plasma phenotype of ether lipids

Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families

Inflammaging in Endemic Areas for Infectious Diseases

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