Metabolism and secretory function of white adipose tissue: effect of dietary fat

Nascimento, Cláudia Maria da Penha Oller do; Ribeiro, Eliane; Oyama, Lila Missae

doi:10.1590/s0001-37652009000300010

Cited by 44 publications

(20 citation statements)

References 124 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An alteration in any of the related pathways reduces insulin's effectiveness and leads to the insulin-resistance and glucose intolerance associated with advancing age [35]. Adiponectin is an adipokines secreted by the adipose tissue, and has been suggested to be an important regulator of insulin action, thereby possibly linking adiposity and insulin sensitivity [36]. …”

Section: Discussionmentioning

confidence: 99%

Exercise training improves sleep pattern and metabolic profile in elderly people in a time-dependent manner

et al. 2011

View full text Add to dashboard Cite

Aging and physical inactivity are two factors that favors the development of cardiovascular disease, metabolic syndrome, obesity, diabetes, and sleep dysfunction. In contrast, the adoption a habitual of moderate exercise may present a non-pharmacological treatment alternative for sleep and metabolic disorders. We aimed to assess the effects of moderate exercise training on sleep quality and on the metabolic profile of elderly people with a sedentary lifestyle. Fourteen male sedentary, healthy, elderly volunteers performed moderate training for 60 minutes/day, 3 days/week for 24 wk at a work rate equivalent to the ventilatory aerobic threshold. The environment was kept at a temperature of 23 ± 2°C, with an air humidity 60 ± 5%. Blood and polysomnographs analysis were collected 3 times: at baseline (1 week before training began), 3 and 6 months (after 3 and 6 months of training). Training promoted increasing aerobic capacity (relative VO2, time and velocity to VO2max; p < 0.05), and reduced serum NEFA, and insulin concentrations as well as improved HOMA index (p < 0.05), and increased adiponectin levels (p < 0.05), after 3 months of training when compared with baseline data. The sleep parameters, awake time and REM sleep latency were decreased after 6 months exercise training (p < 0.05) in relation baseline values. Our results demonstrate that the moderate exercise training protocol improves the sleep profile in older people, but the metabolism adaptation does not persist. Suggesting that this population requires training strategy modifications as to ensure consistent alterations regarding metabolism.

show abstract

Section: Discussionmentioning

confidence: 99%

Exercise training improves sleep pattern and metabolic profile in elderly people in a time-dependent manner

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Several research groups have reported that consumption of saturated fat suppresses production of the insulin-sensitizing adipokine adiponectin in white adipose tissue of humans and rodents (reviewed in [42], [43]. Furthermore, Fernandez-Real et al demonstrated a negative correlation between palmitate and circulating adiponectin in human serum [44].…”

Section: Discussionmentioning

confidence: 99%

The Multi-Level Action of Fatty Acids on Adiponectin Production by Fat Cells

et al. 2011

View full text Add to dashboard Cite

Current epidemics of diabetes mellitus is largely caused by wide spread obesity. The best-established connection between obesity and insulin resistance is the elevated and/or dysregulated levels of circulating free fatty acids that cause and aggravate insulin resistance, type 2 diabetes, cardiovascular disease and other hazardous metabolic conditions. Here, we investigated the effect of a major dietary saturated fatty acid, palmitate, on the insulin-sensitizing adipokine adiponectin produced by cultured adipocytes. We have found that palmitate rapidly inhibits transcription of the adiponectin gene and the release of adiponectin from adipocytes. Adiponectin gene expression is controlled primarily by PPARγ and C/EBPα. Using mouse embryonic fibroblasts from C/EBPα-null mice, we have determined that the latter transcription factor may not solely mediate the inhibitory effect of palmitate on adiponectin transcription leaving PPARγ as a likely target of palmitate. In agreement with this model, palmitate increases phosphorylation of PPARγ on Ser273, and substitution of PPARγ for the unphosphorylated mutant Ser273Ala blocks the effect of palmitate on adiponectin transcription. The inhibitory effect of palmitate on adiponectin gene expression requires its intracellular metabolism via the acyl-CoA synthetase 1-mediated pathway. In addition, we found that palmitate stimulates degradation of intracellular adiponectin by lysosomes, and the lysosomal inhibitor, chloroquine, suppressed the effect of palmitate on adiponectin release from adipocytes. We present evidence suggesting that the intracellular sorting receptor, sortilin, plays an important role in targeting of adiponectin to lysosomes. Thus, palmitate not only decreases adiponectin expression at the level of transcription but may also stimulate lysosomal degradation of newly synthesized adiponectin.

show abstract

“…leptin and adiponectin), glucose tolerance and insulin sensitivity (adiponectin and resistin) and classical cytokines (e.g. TNF-α, interleukin-6 and 10) [3, 4]. …”

Section: Introductionmentioning

confidence: 99%

Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice

Moreno

Okuda

Lira

et al. 2014

Diabetol Metab Syndr

View full text Add to dashboard Cite

BackgroundObesity is associated with increased adipose tissue and glucose intolerance. High-fat diets (HFDs) are known to induce obesity and increase proinflammatory adipokines. The consumption of green tea may improve the health of obese individuals because it contains a potent antioxidant that has effects on body weight, energy expenditure and serum cholesterol concentrations.MethodsWe examined the effects of epigallocatechin-3-gallate (EGCG) (50 mg/kg body weight per day) or saline after 30 or 60 days of treatment. Mice were distributed into four groups: 1) NS: normolipidic diet receiving saline; 2) NE: normolipidic diet receiving EGCG; 3) HFS: high-fat diet receiving saline; 4) HFE: high-fat diet receiving EGCG.ResultsWe observed that administration of a HFD plus EGCG treatment for 60 days reduced delta weight, the relative weights of the mesenteric adipose tissue (MES), retroperitonial adipose tissue (RET), epididymal adipose tissue (EPI), the sum of the adipose tissues (SAT), reduced triacylglycerol (TG) and improved both high-density lipoprotein (HDL) cholesterol levels and the adiponectin/STA ratio when compared with HFS.ConclusionsOur results suggest that the chronic administration of EGCG (60 days) promoted a significant improvement in glucose tolerance, decreased adipose tissue deposits, weight mass, TG and HDL-C only when associated with high-fat diet treatment.

show abstract

Metabolism and secretory function of white adipose tissue: effect of dietary fat

Cited by 44 publications

References 124 publications

Exercise training improves sleep pattern and metabolic profile in elderly people in a time-dependent manner

Exercise training improves sleep pattern and metabolic profile in elderly people in a time-dependent manner

The Multi-Level Action of Fatty Acids on Adiponectin Production by Fat Cells

Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice

Contact Info

Product

Resources

About