Metabolism and Roles of Eicosanoids in Brain

Farooqui, Akhlaq A.

doi:10.1007/978-1-4419-9940-5_1

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2023

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“…Membrane changes particularly in glial cells have consequences on pro-inflammatory receptor localization and related signaling cascades ( 80 ). Not the least, EPA lowers AA and DHA antagonizes the pro-inflammatory effects of AA products ( 81 ).…”

Section: Discussionmentioning

confidence: 99%

The effect of omega-3 fatty acids on alcohol-induced damage

2023

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Alcohol is the most widely consumed psychoactive substance in the world that has a severe impact on many organs and bodily systems, particularly the liver and nervous system. Alcohol use during pregnancy roots long-lasting changes in the newborns and during adolescence has long-term detrimental effects especially on the brain. The brain contains docosahexaenoic acid (DHA), a major omega-3 (n-3) fatty acid (FA) that makes up cell membranes and influences membrane-associated protein function, cell signaling, gene expression and lipid production. N-3 is beneficial in several brain conditions like neurodegenerative diseases, ameliorating cognitive impairment, oxidative stress, neuronal death and inflammation. Because alcohol decreases the levels of n-3, it is timely to know whether n-3 supplementation positively modifies alcohol-induced injuries. The aim of this review is to summarize the state-of-the-art of the n-3 effects on certain conditions caused by alcohol intake, focusing primarily on brain damage and alcoholic liver disease.

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Section: Discussionmentioning

confidence: 99%