Metabolism and Obesity: Role of Leptin Receptor Gene

Иевлева, К Д; Ievleva, Kseniia; Баирова, Татьяна Ананьевна; Bairova, T. A.; Рычкова, Л. В.; Rychkova, Lyubov; Sheneman, Ekaterina; Храмова, Е. Б.; Hramova, Elena; Колесникова, Л. В.; Kolesnikova, Lyubov

doi:10.12737/article_59e85cb55584e4.51145791

Cited by 5 publications

(1 citation statement)

References 10 publications

(21 reference statements)

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“…Установлено, что ожирение связано с хроническим воспалением жировой ткани, активацией провоспалительных реакций, дислипидемией,развитиемокислительногострессаит.д. [5,6]. Следствием прогрессирования окислительного стресса является накопление в организме цитотоксичныхсоединений,втомчислеэндогенныхальдегидов, выступающих в качестве медиаторов повреждения и провоцирующих характерные сдвиги в обмене веществ [5,7,8].Особуюрольвданномслучаеможет играть снижение мощности многокомпонентной антиоксидантной системы организма, состоящей из факторов ферментативной и неферментативной природы [9].…”

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Lipids methabolism and antioxidant status in exogenous constitutional obesity in girls of Buryatia

Колесникова

Даренская

Rychkova

et al. 2021

Ross. vestn. perinatol. pediatr.

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The study of adolescent obesity and pathogenic factors of its development is getting more and more important as the disease aggravates in adulthood. The serious progress in the study of the pathogenesis of this process can be achieved by analyzing the molecular mechanisms of the obesity development in childhood and adolescence. An individual approach to the diagnosis and treatment of obesity includes various factors, including the patient’s nationality. In recent decades there is an increase in the incidence of obesity among the representatives of the Mongoloid race, which is not characteristic of this racial group. Thus, the aim of the study was to analyze the state of lipid metabolism and the level of antioxidant components in the Buryat girls with exogenous constitutional obesity of the 1st degree. The authors examined 44 girls with exogenous constitutional obesity of the 1st degree and 48 practically healthy adolescent girls (comparison group) of the same age. All the girls belonged to the Buryat ethnic group. They used spectrophotometric and fluorometric research methods. The study revealed that exogenous constitutional obesity in adolescent girls is accompanied by the development of dyslipidemia (increased concentrations of total cholesterol, triacylglycerols, very low density lipoprotein cholesterol, an increase in the atherogenic coefficient, a decreased level of high density lipoprotein cholesterol), as well as a deficiency of antioxidant defense components (decreased levels α-tocopherol, retinol, activity of superoxide dismutase and glutathione-S-transferase). These results expand the understanding of the pathophysiological mechanisms of adolescent obesity and develop individual approaches to the treatment of this condition.

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Lipids methabolism and antioxidant status in exogenous constitutional obesity in girls of Buryatia

Колесникова

Даренская

Rychkova

et al. 2021

Ross. vestn. perinatol. pediatr.

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Meta-analysis investigating the impact of the LEPR rs1137101 (A>G) polymorphism on obesity risk in Asian and Caucasian ethnicities

Supti,

Akter,

Rahman

et al. 2024

Heliyon

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Correlations of Gene Variants LEP rs2167270, LEPR rs1137100, GHRL rs696217, rs27647, and NPY rs16147 with Obesity and Adolescent Eating Behavior: Case-Control Study

Кочетова

Shangareeva

Викторова

et al. 2022

Vopr. sovr. pediatr.

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Background. Childhood obesity is topical global healthcare issue. The correlations between variable regions of genes encoding leptin and its receptor, ghrelin and neuropeptide Y, and the risk of obesity development in children have not been confirmed completely. Mechanisms for implementing such correlation via the influence of genes on children’s behavior remain unexplored.Objective. The aim of the study is to examine the correlation between leptin, leptin receptor, ghrelin and neuropeptide Y gene variants and obesity in adolescents and their eating behavior.Methods. The study included children aged from 10 to 18 years with exogenous constitutive obesity and normal body weight. Variants in genes for leptin LEP rs2167270, leptin receptor LEPR rs1137100, ghrelin GHRL rs696217 and rs27647, neuropeptide Y NPY rs16147 were determined. Adolescents’ eating behavior was evaluated via psychometric questionnaires DEBQ (Dutch Eating Behavior Questionnaire) and TFEQ (the Three Factor Eating Questionnaire).Results. Gene variant distribution analysis in 150 obese and 150 normal weight children has revealed correlation with obesity for the variant rs1137100 of the LEPR gene (p = 0.001). Variants rs2167270 of the LEP gene (p = 0.015), rs696217 of the GHRL gene (p = 0.040), and rs16147 of the NPY gene (p = 0.020) were associated with adolescent eating behavior predisposing to obesity.Conclusion. The leptin receptor gene variant rs1137100 is associated with obesity in adolescents, and the variants rs2167270 of the leptin gene, rs696217 of the ghrelin gene, and rs16147 of the neuropeptide Y gene are associated with changes in eating behavior.

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Metabolism and Obesity: Role of Leptin Receptor Gene

Cited by 5 publications

References 10 publications

Lipids methabolism and antioxidant status in exogenous constitutional obesity in girls of Buryatia

Lipids methabolism and antioxidant status in exogenous constitutional obesity in girls of Buryatia

Meta-analysis investigating the impact of the LEPR rs1137101 (A>G) polymorphism on obesity risk in Asian and Caucasian ethnicities

Correlations of Gene Variants LEP <i>rs2167270</i>, LEPR <i>rs1137100</i>, GHRL <i>rs696217</i>, <i>rs27647</i>, and NPY <i>rs16147</i> with Obesity and Adolescent Eating Behavior: Case-Control Study

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