Metabolism and functions of cyclic AMP in nerve

Drummond, George I.; Ma, Yvonne

doi:10.1016/0301-0082(73)90002-6

Cited by 11 publications

(3 citation statements)

References 182 publications

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“…Adenosine 3',5'-monophosphate (cyclic AMP) is accepted as a modulator of activity in many types of cell and tissue including those of the mammalian central nervous system (for reviews see Drummond & Ma, 1975;Kebabian, 1977;Nathanson, 1977). However, characterization of the cyclic AMP system has depended extensively on the use of tissues in vitro.…”

Section: Introductionmentioning

confidence: 99%

THERMOREGULATORY EFFECTS OF N⁶‐2′‐O‐DIBUTYRYL ADENOSINE 3′,5′‐MONOPHOSPHATE IN THE RESTRAINED MOUSE

Dascombe

Milton

Nyemitei-Addo

et al. 1980

British J Pharmacology

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1The N6-2'-O-dibutyryl derivative of adenosine 3',5'-monophosphate (db cyclic AMP) has been micro-injected into the third cerebral ventricle of the unanaesthetized, restrained mouse and the effects on body temperature and thermoregulatory activities observed. 2 Db cyclic AMP (4, 16 and 32 jg) injected intracerebroventricularly produced hypothermia when compared with temperature responses to sodium n-butyrate (6.8 jg). 3 Hypothermia induced by db cyclic AMP in mice was associated with a fall in oxygen consumption together with behavioural and autonomic heat loss activities but not cutaneous vasodilatation. The effects on rectal temperature and oxygen consumption were dose-dependent. 4 The falls in rectal temperature and oxygen consumption induced by db cyclic AMP (4 ,ug) were decreased by elevation of the environmental temperature from 22 to 32°C and abolished at 36°C. 5 It is concluded db cyclic AMP may inhibit central events mediating the rise in metabolic heat production in mice upon exposure to cold environments.

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Section: Introductionmentioning

confidence: 99%

THERMOREGULATORY EFFECTS OF N⁶‐2′‐O‐DIBUTYRYL ADENOSINE 3′,5′‐MONOPHOSPHATE IN THE RESTRAINED MOUSE

Dascombe

Milton

Nyemitei-Addo

et al. 1980

British J Pharmacology

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“…Much of the evidence supporting a role for cyclic nucleotides in mediating certain postsynaptic potentials has been reviewed in detail elsewhere (Drummond and Ma 1973;Bloom 1975;Nathanson and Greengard 1976). Therefore it seems that rather than presenting further supportive evidence here, it is more appropriate to emphasize instead some of the difficulties that have been encountered in attempting to relate cyclic nucleotides to the generation of post-synaptic potentials.…”

Section: Cyclic Nucleotides and The Genesis Of Postsynaptic Potentialsmentioning

confidence: 99%

Cyclic Nucleotides, Protein Phosphorylation and Synaptic Function

Beam¹,

Greengard²

1976

Cold Spring Harbor Symposia on Quantitative Biology

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During the past few years, our laboratory has been interested in the possible involvement of cyclic nucleotides and protein phosphorylation in neuronal function. A major part of this work has been directed towards evaluating the possibility that cyclic AMP is responsible for the genesis of slow postsynaptic potentials at certain synapses. The question of a similar function for cyclic GMP as a mediator of the action of neurotransmitters at other types of synapses has also been considered. In addition, evidence supporting two other roles for cyclic AMP and protein phosphorylation in nervous function, that of regulating microtubular function and that of regulating neurotransmitter synthesis, has been obtained. A schematic diagram illustrating these various proposed roles is shown in Figure 1. In this article, we shall summarize some of these studies on the possible involvement of cyclic nucleotides in neuronal function and also indicate briefly some important unresolved issues and possible approaches toward their resolution.

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“…Cyclic AMP has been implicated in the functioning of the central nervous system, and there is evidence indicating that cyclic nucleotides are involved in the control of cell growth and differentiation (for review, see Drummond, 1973). The concentration of cyclic AMP in rat brain has been reported to increase throughout development (Schmidt, Palmer, Dettbaru & Robison, 1970;Ebadi, Weiss & Costa, 1971), but the method of sacrifice used in these studies does not eliminate rapid post-mortem changes in the nucleotide .…”

Section: University Of Sheffieldmentioning

confidence: 99%

PROCEEDINGS OF THE British Pharmacological Society

1975

British J Pharmacology

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Metabolism and functions of cyclic AMP in nerve

Cited by 11 publications

References 182 publications

THERMOREGULATORY EFFECTS OF N⁶‐2′‐O‐DIBUTYRYL ADENOSINE 3′,5′‐MONOPHOSPHATE IN THE RESTRAINED MOUSE

THERMOREGULATORY EFFECTS OF N⁶‐2′‐O‐DIBUTYRYL ADENOSINE 3′,5′‐MONOPHOSPHATE IN THE RESTRAINED MOUSE

Cyclic Nucleotides, Protein Phosphorylation and Synaptic Function

PROCEEDINGS OF THE British Pharmacological Society

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Metabolism and functions of cyclic AMP in nerve

Cited by 11 publications

References 182 publications

THERMOREGULATORY EFFECTS OF N6‐2′‐O‐DIBUTYRYL ADENOSINE 3′,5′‐MONOPHOSPHATE IN THE RESTRAINED MOUSE

THERMOREGULATORY EFFECTS OF N6‐2′‐O‐DIBUTYRYL ADENOSINE 3′,5′‐MONOPHOSPHATE IN THE RESTRAINED MOUSE

Cyclic Nucleotides, Protein Phosphorylation and Synaptic Function

PROCEEDINGS OF THE British Pharmacological Society

Contact Info

Product

Resources

About

THERMOREGULATORY EFFECTS OF N⁶‐2′‐O‐DIBUTYRYL ADENOSINE 3′,5′‐MONOPHOSPHATE IN THE RESTRAINED MOUSE

THERMOREGULATORY EFFECTS OF N⁶‐2′‐O‐DIBUTYRYL ADENOSINE 3′,5′‐MONOPHOSPHATE IN THE RESTRAINED MOUSE