Abstract:Due to ubiquitous use of organophosphate esters (OPEs) as flame retardants and plasticizers, they have been found at high concentrations in a variety of environmental media while having low or non-detectable levels in biota, including fish. The exposure and fate of OPEs in fish depends on understanding the toxicokinetics, though studies on OPE metabolism are lacking. A model in vitro microsomal-based metabolism assay for rainbow trout (Oncorhynchus mykiss) was utilized to investigate OPE metabolism. Metabolic … Show more
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