Metabolism and excretion of [14C] verruculogen in a sheep

Perera, K.P.W.C.; Mantle, Peter G.; Penny, Ralph

doi:10.1016/s0034-5288(18)32393-2

Cited by 8 publications

(2 citation statements)

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“…The metabolism of verruculogen in animals is not fully understood, but studies with rats and sheep have indicated that it is metabolized in the liver to more polar products (including the tremorgen TR-2), which are excreted into the bile (20,21). The toxin affects the central nervous system; its possible mode of action is by interference with cerebrocortical nerve endings (synaptosomes), causing changes in the amino acid neurotransmitter release mechanisms (17,19,23).…”

Section: Discussionmentioning

confidence: 99%

Tremorgenic mycotoxins from Aspergillus fumigatus as a possible occupational health problem in sawmills

Land¹,

Hult²,

Fuchs³

et al. 1987

Appl Environ Microbiol

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Wood-trimmers' disease, generally called extrinsic allergic alveolitis, which affects workers in sawmills, is thought to be caused by fungal diaspores. The importance of Aspergillusfumigatus on the surface of wood dried in kilns is accentuated by its ability to produce tremorgenic mycotoxins. Eight strains of A. fumigatus from five different sawmills were isolated and cultivated on liquid media, and one of the strains was also cultivated on wood blocks. Extracts were prepared, and the tremorgenic reactions were induced by oral administration of extracts to rats. Extracts of the strain grown in liquid medium and on wood blocks induced very strong tremorgenic reactions when administered orally to rats. Four other strains induced mild tremorgenic reactions. High-performance liquid chromatography analysis revealed two tremorgenic mycotoxins, verruculogen and fumitremorgen C, in the five toxic strains. One nontoxic strain produced detectable levels of verruculogen. These results, coupled with the known resemblance of the acutely toxic phase of wood-trimmers' disease to the symptoms produced by these tremorgens, imply that wood-trimmers' disease and similar occupational diseases are, at least in part, mycotoxicoses.

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Section: Discussionmentioning

confidence: 99%

Tremorgenic mycotoxins from Aspergillus fumigatus as a possible occupational health problem in sawmills

Land¹,

Hult²,

Fuchs³

et al. 1987

Appl Environ Microbiol

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“…The latter four mycotoxins are members'of the fumitremorgin group that also includes TR-2. Fumitremorgins cause tremors and convulsions, and may cause death in animals as a result of reversible biochemical changes affecting neurotransmission (Perera et al, 1982;Yamazaki et al, 1979).…”

Section: Introductionmentioning

confidence: 99%

Influence of Atmospheric Oxygen Content on Growth and Fumitremorgin Production by a Heat‐resistant Mold, Neosartorya fischeri

Nielsen

Beuchat

Frisvad

1989

Journal of Food Science

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Growth and fumitremorgin production by a heat-resistant mold, Neosurtorya fischeri, in atmospheres containing 0.0095-20.9% 02 were studied over a 38-day period. The mold was cultured on Czapek Yeast Autolysate agar adjusted to pH 3.5 and 7.0 and incubated at 25°C in darkness. Colonies were cxamincd and extracts were analyzed for fumitremorgin content using high performance liquid chromatography. Growth occurred at 0, levels as low as 0.10% but not at 0.0095%. Growth was always associated with production of verruculogcn and fumitremorgins A and C. Production of these fumitremorgins was essentially the same in atmospheres containing 3.0 and 20.9% OZ. but was greatly reduced in an atmosphere containing 1.0 and 0.10% OZ. Fumitremorgin production was not significantly different at pH 3.5 and 7.0

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