Metabolism and disposition of juglone in male F344 rats

Chen, L.-J.; Lebetkin, E. H.; Burka, L T

doi:10.1080/00498250500356621

Cited by 12 publications

(8 citation statements)

References 14 publications

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“…Recently, Chen et al43 studied the metabolism and disposition of 14 C‐labeled juglone in male F344 rats following oral, intravenous, and dermal administration. They reported high levels of juglone‐derived radioactivity in kidney for all three dosing routes, which is similar to what we observed following intravenous dosing of 3 H‐labeled juglone in C57/BL mice.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Pharmacokinetic, Biodistribution, Pharmacodynamic, and Toxicity Profile of Free Juglone and Its Sterically Stabilized Liposomes

Aithal

Kumar

Rao

et al. 2011

Journal of Pharmaceutical Sciences

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Section: Resultsmentioning

confidence: 99%

Evaluation of Pharmacokinetic, Biodistribution, Pharmacodynamic, and Toxicity Profile of Free Juglone and Its Sterically Stabilized Liposomes

Aithal

Kumar

Rao

et al. 2011

Journal of Pharmaceutical Sciences

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“…25 Assuming complete distribution throughout all body water, the 1 mg/kg dose of juglone used here should generate a maximal concentration of approximately 10 mmol/L, of which only 0.01% to 0.4% was found in the lung 24 hours after administration. 33 Therefore it is very unlikely that CyA or FKBP12 were affected by juglone treatment. Although juglone has been shown to affect other enzymes, including RNA polymerase II, 34 the inhibitory concentration of 50% was approximately 10-fold that used here.…”

Section: Discussionmentioning

confidence: 99%

A critical role for Pin1 in allergic pulmonary eosinophilia in rats

Esnault

Rosenthal²,

Sedgwick³

et al. 2007

Journal of Allergy and Clinical Immunology

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“…The lower part of the Figure present a few quinones whose reduction has been given particular attention. Compounds such as menadione (2.390; vitamin K 3 ; R¼ CH 3 , R' ¼ H) and the natural product juglone (2.390; R¼ H, R' ¼ OH) offer examples of the easy reduction and detoxification of 1,4naphthoquinones and other polycyclic aromatic hydrocarbon quinones [355] [358] [359]. As for diethylstilbestrol (2.313), we presented in Fig.…”

Section: Fig 2130mentioning

confidence: 99%

The Biochemistry of Drug Metabolism — An Introduction. Part 2. Redox Reactions and Their Enzymes

Testa

Kraemer

2007

ChemInform

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This Part 2 of our biochemical introduction to drug metabolism [1] presents the redox reactions (oxidations and reductions) and their enzymes. As stated in Part 1, these reactions are clearly the most important ones in drug and xenobiotic metabolism. There are at least three reasons for this state of affairs. First, the biotransformation of a xenobiotic often begins with redox reactions, and particularly reactions catalyzed by cytochromes P450 (abbreviated as CYPs). Second, a vast majority of drugs (and of other xenobiotics, as far as this information is available) are substrates of CYPs [2 -10]. Although any attempt to quantify the total number of marketed drugs, drug candidates, and preclinical candidates that are substrates of human CYPs is but a guess-estimate, a figure of ca. 90% is generally accepted. This percentage is certainly higher when all drug-metabolizing oxidoreductases are taken into account.The third reason for the predominance of redox reactions in drug metabolism is the large diversity of metabolites that may be produced from a single substrate. This diversity involves differences in the chemical nature of the resulting functional groups (chemoselectivity, e.g., a phenolic OH vs. an N-oxido group), as well as positional or stereochemical differences in the creation of a single type of functional group (regioselectivity, e.g., an ortho-vs. a para-phenolic OH, or stereoselectivity, e.g., a cis-vs. trans-alcoholic OH; see Fig. 1.15 in Part 1 [1]). As a first glance of what will be summarized in Part 2, we note here that the metabolites resulting from redox reactions are alcohols, phenols, aldehydes, ketones, carboxylic acids, primary and secondary amines, hydroxylamines, N-oxides, sulfides, sulfoxides or sulfones, to name the major ones. Many of these types of metabolites can be produced by CYP-catalyzed oxidations or reductions. None the less, the contribution of other oxidoreductases should not be underestimated.Some of the reactions catalyzed by CYPs are also carried out (often in parallel on the same substrate) by the flavin-containing monooxygenases (FMOs), another important class of xenobiotic-metabolizing enzymes which will be presented in parallel with the CYPs. Indeed and as we shall see, numerous further oxidoreductases are involved in drug and xenobiotic metabolism [4] [7] [9]. Like CYPs, they can act directly on a foreign substrate or on a metabolite thereof, but none of these oxidoreductases metabolizes as many substrates as CYPs. Still, some of these enzyme systems metabolize a marked number of compounds (e.g., alcohol dehydrogenases) and are

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Metabolism and disposition of juglone in male F344 rats

Cited by 12 publications

References 14 publications

Evaluation of Pharmacokinetic, Biodistribution, Pharmacodynamic, and Toxicity Profile of Free Juglone and Its Sterically Stabilized Liposomes

Evaluation of Pharmacokinetic, Biodistribution, Pharmacodynamic, and Toxicity Profile of Free Juglone and Its Sterically Stabilized Liposomes

A critical role for Pin1 in allergic pulmonary eosinophilia in rats

The Biochemistry of Drug Metabolism — An Introduction. Part 2. Redox Reactions and Their Enzymes

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