Metabolism and cell shape in cancer: A fractal analysis

D’Anselmi, Fabrizio; Valerio, Mariacristina; Cucina, Alessandra; Galli, Luca; Proietti, Sara; Dinicola, Simona; Pasqualato, Alessia; Manetti, Cesare; Ricci, Giulia; Giuliani, Alessandro; Bizzarri, Mariano

doi:10.1016/j.biocel.2010.05.002

Cited by 59 publications

(44 citation statements)

References 29 publications

(26 reference statements)

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“…The studies also argued that the changes of cell morphology would be an indicator of chemoresistance, thereby marking the level of malignancy. 19,20 In line with previous reports, the result in this study has demonstrated an insight on the relationship between phenotype and morphological changes in MCF-7 cisplatin resistance.…”

Section: Discussionsupporting

confidence: 91%

“…5,6 A previous study revealed that the resistance to cisplatin is directly related to the hyperactivity of mitochondria in performing oxidative phosphorylation, which can increase the intracellular metabolism rate. 19 Moreover, growing evidence has shown that significant morphological changes is also linked to cell energy states. 19 With an excessive energy production, the resistant cell lines are able to proceed with DNA repair and expelled cisplatin from the intracellular environment.…”

Section: Discussionmentioning

confidence: 99%

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Morphological Changes of Cisplatin-resistant Human Breast Cancer MCF-7 Cell Line

Puspita

Bedford

2017

IJIHS

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Objective: To evaluate morphological changes of breast cancer cell line MCF-7 following the development of acquired resistance towards cisplatin. Resistance towards anticancer agents still plays an important role in the breast cancer chemotherapy failure. Methods:The cisplatin resistant subline MCF-7/CisR was developed in-vitro by cultivating the parental cell line cisplatin-sensitive MCF-7 with raising concentration of cisplatin (from 0.01 to 2.3 µM) for four months. The cell morphology was observed by giemsa staining. Results:The resistance was shown by the increase of IC 50 by 9 folds on MCF-7/CisR compared to the initial IC 50 value of MCF-7. The change in cisplatin cytotoxic potency on the resistant cell line was accompanied by the morphological modification, including the enlargement of cell size, the increase of nucleus and cytoplasm ratio, and the increase of the number of microvesicular and cytoplasmic granules. Conclusions:This result has supported the underlying mechanism of cisplatin resistance, including the ability of the cells to decrease intracellular cisplatin concentration and repair DNA damage effects.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Morphological Changes of Cisplatin-resistant Human Breast Cancer MCF-7 Cell Line

Puspita

Bedford

2017

IJIHS

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“…Moreover, this sensor could be effective in several fields of applications (e.g., Bio-Medical, industrial, wearable), and in particular can also provide a quick estimation of metabolism parameters for discriminating glycolytic vs. oxidizing glucose metabolism. Additionally, as the tool can record in real-time a huge number of observations, it could provide data required for calculating the Ljapunov functions of non-equilibrium processes, like those occurring during metabolism in living systems [7] and pathological conditions, like cancer [8]. …”

Section: Resultsmentioning

confidence: 99%

A Gas Sensor Device for Oxygen and Carbon Dioxide Detection

Santonico

Pennazza

Parente

et al. 2017

Proceedings of Eurosensors 2017, Paris, France, 3–6 September 2017

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Sensors for monitoring oxygen and carbon dioxide are crucial as investigational devices in many different research fields, including environmental, biomedical and industrial. They must be easily configurable, fast responding, and with good reproducibility and sensitivity. The state of art reports different sensing and transducing strategies: electrochemical, optical, conductometric etc., based on specific chemically interactive materials. In this work, a multisensor system based on electrochemical sensors acting via a liquid medium and controlled by a dedicated low-noise electronic interface is equipped with an elaboration unit able in extracting/storing a committed model for oxygen and carbon dioxide detection.

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“…The cellular activity was comparatively estimated using a number of linear and non-linear morphological parameters which describes the cell morphology changing during different activation processes [7,8]. A total of 5 parameters (including 3 linear and 2 nonlinear) were used to describe the cell shape.…”

Section: Influence Of Carrageenan On Macrophage Cell Activitymentioning

confidence: 99%

Immunotropic Effects of Gelling Polysaccharide from Red Alga Tichocarpus crinitus

2017

Nov. 20-22, 2017 Kuala Lumpur (Malaysia) SETH-17, CAENS-17, BDMCE-17, FEWCMB-17, ANPMS-17, ELBIS-17 &Amp; LHSRS-17

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It was shown that gelling polysaccharide from Pacific red alga Tichocarpus crinitus under oral administration have immunomodulatory effect, in particular it influences on cellular activity and cytokines production in mice immune cells. Carrageenan also possesses a protective effect in in LPS-induced endotoxemia model in mice due to reducing an intensity of inflammatory response induced by LPS probably through its modulating effect on cellular activity of peritoneal leukocytes and on cytokine production in blood cells.

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Metabolism and cell shape in cancer: A fractal analysis

Cited by 59 publications

References 29 publications

Morphological Changes of Cisplatin-resistant Human Breast Cancer MCF-7 Cell Line

Morphological Changes of Cisplatin-resistant Human Breast Cancer MCF-7 Cell Line

A Gas Sensor Device for Oxygen and Carbon Dioxide Detection

Immunotropic Effects of Gelling Polysaccharide from Red Alga Tichocarpus crinitus

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