Metabolisierung von Deoxynivalenol beim Schwein: Bestimmung von DON und DOM-1 im Urin vom Schwein

Razzazi, E; Böhm, Josef; Kettner, B.; Hochsteiner, W.; Kahlbacher, Hermann

doi:10.1007/bf02946070

Cited by 4 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This view is further substantiated by the results of who carried out a DONbalance study and found the proportion of de-epoxy-DON of the sum of DON plus deepoxy-DON to be approximately 5 and 97% in urine and faeces, respectively. Similarly, Razzazi et al (2002) found a similar ratio of 5% for urine samples collected over 16 days from pigs fed a diet with a DON-concentration of 14.4 mg/kg. This would suggest that only a little of the gastro-intestinally formed de-epoxy-DON was absorbed and finally excreted via urine.…”

Section: Resultsmentioning

confidence: 51%

On the toxicokinetics and the metabolism of deoxynivalenol (don) in the pig

Dänicke¹,

Valenta²,

Döll³

2004

Archives of Animal Nutrition

133

View full text Add to dashboard Cite

Eleven castrated male pigs weighing 88.1 +/- 3.9 kg on average were adapted to a diet containing DON (4.2 mg DON/kg) over a period of 7 days. Feed was given restrictively with 1.1 kg per meal (two meals per day). On the day of measurement, all pigs were slaughtered at different time intervals following the morning meal containing DON (1, 2, 3, 4, 5, 6, 8, 15, 18 and 24 h after feeding), with the exception of one pig which was slaughtered unfed. DON and de-epoxy-DON were analysed in serum and digesta from consecutive segments of the digestive tract (stomach, small intestine divided into three parts of a similar length, caecum, colon, rectum). DON was rapidly and nearly completely absorbed while passing through the stomach and the proximal small intestine. Maximum serum concentration appeared 4.1 h after the DON-containing meal and half of the systemically absorbed DON was eliminated after 5.8 h. De-epoxy-DON appeared in increasing proportions from the distal small intestine and reached approximately 80% of the sum of DON plus de-epoxy-DON in faeces collected from the rectum. It was concluded that de-epoxydation of DON, which primarily occurs in the hindgut, probably does not contribute much to a detoxification in the pig.

show abstract

Section: Resultsmentioning

confidence: 51%

On the toxicokinetics and the metabolism of deoxynivalenol (don) in the pig

Dänicke¹,

Valenta²,

Döll³

2004

Archives of Animal Nutrition

133

View full text Add to dashboard Cite

show abstract

“…Moreover, the mentioned metabolite ratio agrees with the metabolite profile obtained from porcine urinary spot samples. Razzazi et al (2002) found a mean ratio of five percent and from the results reported by Doll et al (2003), a variation of between 3.7 and 5.4% can be calculated.…”

Section: Discussionmentioning

confidence: 68%

On the effects of deoxynivalenol (DON) in pig feed on growth performance, nutrients utilization and DON metabolism

Dänicke¹,

Goyarts²,

Valenta³

et al. 2004

J. Anim. Feed Sci.

Self Cite

View full text Add to dashboard Cite

Control wheat and wheat artificially inoculated with Fusarium culmorum and as well as wheat contaminated mainly with deoxynivalenol (DON) were gradually blended to yield diets for pigs with increasing DON concentrations (0.2, 0.7, 1.2, 2.5, 3.7 mg/kg) at a total wheat content of 400 g/ kg diet. Performance was recorded over a liveweight range between 34 and 104 kg (n=l 8 per group). Blood was drawn from the jugular vein after five weeks on the experimental diets to determine the clinical-chemical parameters and DON concentrations. In addition, a balance study was carried out with the groups fed the diets with the lowest and the highest DON concentration to test the effects on nutrient digestibility and DON metabolism. DON and its metabolite de-epoxy-DON were analysed in physiological samples by HPLC after cleanup by immuno-affinity columns (IAC). Performance of pigs was not significantly affected by increasing dietary DON concentrations, although there was a trend toward a decrease in weight. This was especially true for the group fed the diet with 3.7 mg DON/kg, which consumed 5% less feed and gained 8% less liveweight than the control group. Serum clinical-chemical parameters, such as albumin, total protein, GLDH, ASAT, y-GT and immunoglobulins were not influenced by the dietary treatments. DON concentration in serum increased in a dose-response-related manner and did clearly reflect the DON exposure of the animals. However, adverse effects on performance were only obvious for the group fed the diet with the highest DON concentration. No significant differences were found for nutrient digestibility of the tested diets. With regard to the DON balance and metabolism, urine was the main excretory route. A total of 52.3% of the ingested DON was eliminated as the parent toxin whereas 2.6% was excreted as the metabolite de-epoxy-DON in the group fed the diet with 3.7 mg DON/kg. The excretion of both substances accounted for

show abstract

Human

Weidenbörner¹

2010

Mycotoxins and Their Metabolites in Humans and Animals

View full text Add to dashboard Cite

Metabolisierung von Deoxynivalenol beim Schwein: Bestimmung von DON und DOM-1 im Urin vom Schwein

Cited by 4 publications

References 2 publications

On the toxicokinetics and the metabolism of deoxynivalenol (don) in the pig

On the toxicokinetics and the metabolism of deoxynivalenol (don) in the pig

On the effects of deoxynivalenol (DON) in pig feed on growth performance, nutrients utilization and DON metabolism

Human

Contact Info

Product

Resources

About