Metabolische Veränderungen des zentralen Nervensystems nach Unterbrechung der zum Neopallium führenden Nervenfasern

Lack of effect of ribaminol, TCAP, and magnesium pemoline on recovery from neocerebellar damage

“…In our previous papers (Reinis, 1960(Reinis, , 1973, we showed that spontaneous nervous reorganization may be accompanied by long•lasting changes of brain metabolism as tissue respiration, tissue temperature, and also turnover of DNA. The existence of these changes, which implies the presence of a permanent adaptation of the cell metabolism, prompted us to perform this experiment.…”

“…Another reason was that we had found that there were permanent metabolic changes in the damaged brain concerning enzymatic activity, temprature, oxidations, etc. (Reinis & Suva, 1966;Reinis, 1960Reinis, , 1961. These changes probably depend on proteosynthesis and control of the cell metabolism by nucleic acids, and may therefore be promoted by substances boosting proteosynthesis.…”

Incorporation of [3H]Thymidine into Brain DNA after Cerebellar Damage

“…We found an increase in the brain temperature, blood flow and vascularity, oxygen consumption, and activity of several enzymes after destruction of different cortical and subcortical areas performed in the early perinatal period. These metabolic changes were detected even I year after the lesion and appeared at the time of almost complete functional recovery (19)(20)(21). The increase of tissue metabolism was found not only in the immediate vicinity of the lesion, but also throughout the whole brain.…”

“…Neurol.. 33: 372 (1971 We su'ppose that a fruitfui approach to the understanding of metabolic changes in the damaged brain which we found earlier 11. Guillery, R. W.: Experiments to determ~ne whether ret~nogen~culate axons can (19)(20)(21) ~h~~, it is possible that the described changes of DNA, 17. Moore.…”