Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome

Molli, Andrea Elena Iglesias; Panero, Julieta; Santos, Patricia Carolina Dos; González, Claudio; Vilariño, Jorge; Sereday, Marta; Cerrone, Gloria Edith; Slavutsky, Irma; Frechtel, Gustavo Daniel

doi:10.1371/journal.pone.0174945

Cited by 15 publications

(6 citation statements)

References 45 publications

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“…Moreover, in the present study, ATL was inversely correlated with BMI. This finding is consistent with several prior studies carried out by our group which showed increases in BMI and the presence of obesity as major determinants of telomere shortening [ 33 , 34 ].…”

Section: Discussionsupporting

confidence: 93%

Leukocyte telomere length is associated with iron overload in male adults with hereditary hemochromatosis

et al. 2020

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Background: Hereditary hemochromatosis (HH) is a primary iron overload (IO) condition. Absolute telomere length (ATL) is a marker of cellular aging and DNA damage associated with chronic diseases and mortality.  Aim: To evaluate the relationship between ATL and IO in patients with HH.</p>  Methods: Cross-sectional study including25 patients with HH: 8 with IO and 17 without IO (ferritin< 300ng/ml) and 25 healthy controls. Inclusion criteria were: age>18 years, male sex and HH diagnosis. Patients with diabetes or other endocrine and autoimmune diseases were excluded. ATL was measured by real-time PCR.</p>  Results: HH patients with IO were older (p<0.001) and showed higher ferritin concentration (p<0.001). Patients with HH, disregarding the iron status, showed higher glucose and BMI than controls (both p<0.01). ATL was shorter in patients with IO than controls [with IO: 8 (6-14), without IO: 13 (9-20),and controls: 19 (15-25) kilobase pairs, p<0.01];with a linear trend within groups (p for trend<0.01). Differences in ATL remained statistically significant after adjusting by age, BMI and glucose(p<0.05).</p>  Discussion: Patients with IO featured shorter ATL while patients without IO showed only mild alterations vs. controls. Screening for IO is encouraged to prevent iron-associated cellular damage and early telomere attrition.

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Section: Discussionsupporting

confidence: 93%

Leukocyte telomere length is associated with iron overload in male adults with hereditary hemochromatosis

et al. 2020

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“…The link between nuchal SAT accumulation, plasma insulin levels and RTL relates a specific SAT distribution pattern to an altered glucose metabolism and accelerated genomic aging, indicated by short RTL. An association between obesity and telomere physiology has been reported before 13,[30][31][32][33][34][35][36] . However, most previous studies used BMI to characterize individuals as overweight/obese or normal weight.…”

Section: Discussionmentioning

confidence: 86%

Telomere shortening associates with elevated insulin and nuchal fat accumulation

Mangge

Herrmann

Almer

et al. 2020

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obesity and relative leucocyte telomere length (RtL) are both linked to accelerated aging and premature mortality. We examined if nuchal subcutaneous adipose tissue (SAt) thickness, a surrogate marker of central trunk-weighted obesity, is an independent predictor of RtL that provides information beyond BMI, metabolic and inflammatory markers. RTL and nuchal SAT thickness were determined in 362 participants of the STYJOBS/EDECTA study (STYrian Juvenile Obesity Study, Early DEteCTion of atherosclerosis), which included overweight individuals and matched eutrophic controls. fasting plasma samples were used for the measurement of leptin, resistin, adiponectin, glucose, insulin, highsensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), liver enzymes, creatinine, cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, oxidized LDL, triglycerides, homocysteine and uric acid. furthermore, all participants underwent carotid artery ultrasound. obese individuals had markedly higher body mass index (BMi), nuchal SAt thickness, hip and waist circumferences and carotid intima media thickness (iMt) than eutrophic controls. in addition, they showed typical biochemical abnormalities related to energy metabolism, systemic inflammation and liver function. RTL was inversely correlated with nuchal SAT thickness, IMT, hs-CRP, alkaline phosphatase, insulin, resistin, and leptin. positive correlations were seen with homocysteine and creatinine. Stepwise linear regression analyses identified nuchal SAT thickness and insulin as the only significant predictors of RTL. In conclusion, nuchal SAT thickness is a robust predictor of RTL that provides information beyond traditional obesity-related metabolic and inflammatory biomarkers. This suggests an important role of fat depots at the neck for accelerated telomere shortening.

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“…The high prevalence of obesity in women with PCOS exacerbates the hormonal and clinical manifestations, contributing to the development of the disorder (26). Obesity and metabolic syndrome are common metabolic alterations in PCOS patients that may lead to a reduction of the TL through oxidative stress and a chronic inflammation state (9,27). Furthermore, many studies have focused on the increased expression and activity of telomerase stimulated by androgens, such as testosterone, in ovarian cancer cells and in cultured peripheral blood lymphocytes (14,15).…”

Section: Discussionmentioning

confidence: 99%

Telomere Length Differently Associated to Obesity and Hyperandrogenism in Women With Polycystic Ovary Syndrome

et al. 2021

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BackgroundPolycystic Ovary Syndrome (PCOS) often present metabolic disorders and hyperandrogenism (HA), facts that may influence the telomere length (TL).AimsTo compare the absolute TL (aTL) between women with PCOS and control women, and their association with the presence of obesity and HA parameters.Materials and methodsThe PCOS group included 170 unrelated women outpatients and the control group, 64 unrelated donor women. Anthropometric, biochemical-clinical parameters and androgen profile were determined. The PCOS patients were divided accordingly to the presence of obesity and androgenic condition. The aTL was determined from peripheral blood leukocytes by Real Time quantitative PCR.ResultsWomen with PCOS exhibited a significantly longer aTL than controls after age adjustment (p=0.001). A stepwise multivariate linear regression in PCOS women, showed that WC (waist circumference) contributed negatively (b=-0.17) while testosterone levels contributed positively (b=7.24) to aTL. The non-Obese PCOS (noOB-PCOS) presented the longest aTL when compared to controls (p=0.001). Meanwhile, the aTL was significantly higher in the hyperandrogenic PCOS phenotype (HA-PCOS) than in the controls (p=0.001) and non hyperandrogenic PCOS phenotype (NHA-PCOS) (p=0.04). Interestingly, when considering obesity and HA parameters in PCOS, HA exerts the major effect over the aTL as non-obese HA exhibited the lengthiest aTL (23.9 ± 13.13 Kbp). Conversely, the obese NHA patients showed the shortest aTL (16.5 ± 10.59 Kbp).ConclusionsWhilst a shorter aTL could be related to the presence of obesity, a longer aTL would be associated with HA phenotype. These findings suggest a balance between the effect produced by the different metabolic and hormonal components, in PCOS women.

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Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome

Cited by 15 publications

References 45 publications

Leukocyte telomere length is associated with iron overload in male adults with hereditary hemochromatosis

Leukocyte telomere length is associated with iron overload in male adults with hereditary hemochromatosis

Telomere shortening associates with elevated insulin and nuchal fat accumulation

Telomere Length Differently Associated to Obesity and Hyperandrogenism in Women With Polycystic Ovary Syndrome

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