Metabolic Systems

Klowden, Marc J.

doi:10.1016/b978-0-12-415819-1.00006-4

Cited by 37 publications

(4 citation statements)

References 435 publications

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“…And the hindgut as the main excretory organ not only completes the discharge of metabolic waste, but also maintains the balance of salt and water in the insect body and the stability of the internal environment. 40 The higher expression levels of HcInR, HcPI3K, HcAKT, HcFOXO and HcTOR genes in the digestive system confirmed the function of the insulin signaling pathway because a conserved nutrient-sensing pathway plays an important role in transducing nutritional information and maintaining organismal homeostasis. 41,42 The insulin signaling pathway affects physiological activities such as glucose uptake, lipid synthesis and gene expression, and plays an important role in the regulation of cell growth and nutrient metabolism.…”

Section: Discussionmentioning

confidence: 78%

“…Generally, the midgut is the main site for secreting digestive enzymes, digesting food and absorbing nutrients. And the hindgut as the main excretory organ not only completes the discharge of metabolic waste, but also maintains the balance of salt and water in the insect body and the stability of the internal environment 40 . The higher expression levels of HcInR , HcPI3K , HcAKT , HcFOXO and HcTOR genes in the digestive system confirmed the function of the insulin signaling pathway because a conserved nutrient‐sensing pathway plays an important role in transducing nutritional information and maintaining organismal homeostasis 41,42 …”

Section: Discussionmentioning

confidence: 94%

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Identification and characterization of key genes in insulin signaling pathway as molecular targets for controlling the fall webworm, Hyphantria cunea

Yan

et al. 2022

Pest Management Science

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Background The insulin signaling pathway is closely related to metabolism, growth, reproductive capacity and lifespan of insects. However, the physiological function of the insulin signaling pathway is little known in Hyphantria cunea. Results Five insulin signaling pathway genes (HcInR, HcPI3K, HcAKT, HcFOXO and HcTOR) in H. cunea were identified and characterized in this study. The spatiotemporal expression profiles of the genes showed that HcInR, HcAKT, HcPI3K and HcTOR expressions were higher at the egg stage than those in other development stages, whereas HcFOXO was highly expressed in the adult stage; all of these genes were highly expressed in the larval digestive system, especially in the midgut and hindgut. After RNA interference (RNAi) of the five genes in 5th instar H. cunea larvae, weight gain and survival rate (except in the siHcAKT‐injected group) were significantly decreased, and the developmental duration of larval and pupal stages were prolonged. In addition, knockdown of five genes in 7th instar larvae decreased the pupation rate, survival rate and oviposition capacity, and resulted in abnormal development during larval–pupal transition. Conclusion Our findings indicate that the insulin signaling pathway plays essential roles in growth and development and the molting process in H. cunea, providing an important basis for developing new potentially molecular targets for RNAi‐based pest control and understanding the mechanism of H. cunea outbreak. © 2022 Society of Chemical Industry.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 94%

Identification and characterization of key genes in insulin signaling pathway as molecular targets for controlling the fall webworm, Hyphantria cunea

Yan

et al. 2022

Pest Management Science

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“…The peritrophic membrane, matrix (PM) or peritrophic envelope is a structure, which is found in the midgut of insects that have the chewing mouthparts and feed on with solid, and secreted by the midgut epithelial cells (Pimenta et al, 1997;Chapman, 2013;Klowden, 2013;Li et al, 2018;Thorsson, 2018). The main roles of the PM include not only preventing the damage of epithelial cells by the luminal contents, but also protecting them from pathogenic microorganisms and toxins.…”

Section: Resultsmentioning

confidence: 99%

Morphology and Fine Organization of the Midgut of Poecilimon ataturki Ünal, 1999 (Orthoptera: Tettigoniidae)

Mutlu

2021

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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In order to do detailed experiments about the internal organs of the insects or to improve new methods relevant to pest management, the biology of the species should be well known. For this reason, this paper deals with Poecilimon ataturki Ünal, 1999 (Orthoptera: Tettigoniidae) which is a bush cricket and is known to be harmful to nature. The morphology and structure of the midgut of P. ataturki have been investigated using light microscopy and scanning electron microscopy (SEM). The midgut of this species has two main regions called the ventriculus and the gastric caecum. The ventriculus has a tubular structure morphologically, whereas the gastric caecum has a bulbous structure. The ventriculus has two cell types in the epithelial layer as the principle and the regenerative cells. The fine structure of the ventriculus and the gastric caecum cells revealed that the secretion activity moves from cell to lumen. These structures show a high level of similarity compared with the midgut structure of the previously studied species in the Orthoptera order despite some differences. It is thought that the enlightenment of the midgut structure of this species will contribute to science for insect pest management.

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“…Insects are the largest and most diverse group of animals on Earth. They can be fungivores, herbivores (including pollinators), parasitoids, predators, or saprophytes in a huge range of terrestrial habitats spanning all seven continents ( 3 ). Despite this variation in habitat and feeding habits, maintaining energetic and nutritional homeostasis at the organismal and physiological level, remains a conserved evolutionary problem ( 4 – 7 ), so how do insects achieve optimal energy intake and nutritional balance with very little food storage buffering capacity, due to their small size?…”

mentioning

confidence: 99%

Editorial: New advances in understanding the regulation of appetite in insects

Mayack,

Le Gall,

Ihle

2024

Front. Insect Sci.

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Metabolic Systems

Cited by 37 publications

References 435 publications

Identification and characterization of key genes in insulin signaling pathway as molecular targets for controlling the fall webworm, Hyphantria cunea

Identification and characterization of key genes in insulin signaling pathway as molecular targets for controlling the fall webworm, Hyphantria cunea

Morphology and Fine Organization of the Midgut of Poecilimon ataturki Ünal, 1999 (Orthoptera: Tettigoniidae)

Editorial: New advances in understanding the regulation of appetite in insects

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