Metabolic syndrome: prevalence, associated factors, and C-reactive protein

Martínez, María Antonia; Puig, Juan; Mora, Marta; Aragón, Rosa; O'Dogherty, Pascual; Antón, J.; Sánchez-Villares, Teresa; Rubio, José M.; Rosado, J.A.; Torres, Rosa J.; Marcos, Joaquín; Pallardo, Luís Felipe; Banegas, José R.

doi:10.1016/j.metabol.2008.04.017

Cited by 45 publications

(28 citation statements)

References 26 publications

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“…The actual prevalence of obesity is 30.5% and that of associated metabolic syndrome is 24% in the US population [3,5] . In Europe, the age-and sex-adjusted prevalence of metabolic syndrome was 24.6% using the 2005 ATP Ⅲ definition and 30.9% using the International Diabetes Federation definition, according to the MADRIC study (MADrid Rlsego Cardiovascular Study) performed on 1344 participants [6] . In this study, the authors found a good overall agreement between the ATP Ⅲ and IDF definitions, much closer in women than in men (κ = 0.92 ± 0.07 vs κ = 0.66 ± 0.06).…”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and risk of subsequent colorectal cancer

Pais¹,

Silaghi²,

Silaghi³

et al. 2009

WJG

153

145

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The metabolic syndrome and visceral obesity have an increasing prevalence and incidence in the general population. The actual prevalence of the metabolic syndrome is 24% in US population and between 24.6% and 30.9% in Europe. As demonstrated by many clinical trials (NAHANES Ⅲ, INTERHART) the metabolic syndrome is associated with an increased risk of both diabetes and cardiovascular disease. In addition to cardiovascular disease, individual components of the metabolic syndrome have been linked to the development of cancer, particularly to colorectal cancer. Colorectal cancer is an important public health problem; in the year 2000 there was an estimated total of 944 717 incident cases of colorectal cancer diagnosed world-wide. This association is sustained by many epidemiological studies. Recent reports suggest that individuals with metabolic syndrome have a higher risk of colon or rectal cancer. Moreover, the clusters of metabolic syndrome components increase the risk of associated cancer. The physiopathological mechanism that links metabolic syndrome and colorectal cancer is mostly related to abdominal obesity and insulin resistance. Population and experimental studies demonstrated that hyperinsulinemia, elevated C-peptide, elevated body mass index, high levels of insulin growth factor-1, low levels of insulin growth factor binding protein-3, high leptin levels and low adiponectin levels are all involved in carcinogenesis. Understanding the pathological mechanism that links metabolic syndrome and its components to carcinogenesis has a major clinical significance and may have profound health benefits on a number of diseases including cancer, which represents a major cause of mortality and morbidity in our societies.

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Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and risk of subsequent colorectal cancer

Pais¹,

Silaghi²,

Silaghi³

et al. 2009

WJG

153

145

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“…The age-and sex-adjusted prevalence of metabolic syndrome was 24.6% using the ATP III definition and 30.9% using the IDF definition. Prevalence figures by both definitions were higher in men than in women and increased with age [14].…”

Section: Literature Reviewmentioning

confidence: 83%

Prevalence of Metabolic Syndrome among Primary Health Care Attendees in King Fahad Armed Forces Hospital in Jeddah

Ma¹,

Mr²,

Hassan³

et al. 2018

Arch Med

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“…Multiple cross-sectional and prospective epidemiological studies showed an association between hs-CRP and the metabolic syndrome and its components [11][12][13][14][15][16][17][18][19][20]. However, the mechanisms responsible for the low-grade up-regulation of CRP production that predicts development of the metabolic abnormalities in general population are not clearly understood.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported a relationship between components of the metabolic syndrome, according to the ATP III definition, and hs-CRP [16,17,20,35,36].…”

Section: Discussionmentioning

confidence: 99%